Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0481 Transporter Info
Gene Name	SLC9A1
Transporter Name	Sodium/hydrogen exchanger 1
Gene ID	6548
UniProt ID	P19634

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Mycotoxins
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 results in increased methylation of SLC9A1 exon		[33]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Aflatoxin B1 results in increased methylation of SLC9A1 intron		[33]
Regulation Mechanism			Transcription Factor Info
aflatoxin B2	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aflatoxin B2 results in increased methylation of SLC9A1 intron		[33]
Regulation Mechanism			Transcription Factor Info
Nanoparticle
perfluoro-n-nonanoic acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in decreased expression of SLC9A1 mRNA		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	perfluoro-n-nonanoic acid results in increased expression of SLC9A1 mRNA		[52]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Paclitaxel	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Paclitaxel inhibits the activity of SLC9A1		[1]
Troglitazone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Troglitazone inhibits the activity of SLC9A1		[2]
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide inhibits the expression of SLC9A1		[4]
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol affects the expression of SLC9A1		[5]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zidovudine increases the expression of SLC9A1		[6]
Valproic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of SLC9A1		[7]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Urethane increases the expression of SLC9A1		[8]
Dronabinol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dronabinol increases the expression of SLC9A1		[9]
Doxorubicin	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the expression of SLC9A1		[10]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin increases the expression of SLC9A1		[11]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine increases the expression of SLC9A1		[12]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen increases the expression of SLC9A1		[13]
Drug Marketed but not Approved by US FDA
Zinc chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zinc chloride increases the expression of SLC9A1		[3]
Drug in Phase 3 Trial
Resveratrol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Resveratrol increases the expression of SLC9A1		[18]
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of SLC9A1		[26]
Drug in Phase 1 Trial
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite increases the expression of SLC9A1		[15]
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the expression of SLC9A1		[17]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 increases the expression of SLC9A1		[20]
Investigative Drug
Ethyl isopropylamiloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethyl isopropylamiloride inhibits the activity of SLC9A1		[14]
Natural Product
Phloretin	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phloretin inhibits the activity of SLC9A1		[16]
DT Modulation1	Resveratrol results in increased expression of SLC9A1 protein which results in increased uptake of Sodium Chloride		[18]
Regulation Mechanism			Transcription Factor Info
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of SLC9A1		[28]
Acute Toxic Substance
Formaldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Formaldehyde increases the expression of SLC9A1		[19]
Carcinogen
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene increases the expression of SLC9A1		[27]
Arsenic	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic affects the methylation of SLC9A1 gene		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC9A1 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
Cadmium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in decreased expression of SLC9A1 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
Nickel	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nickel results in increased expression of SLC9A1 mRNA		[48]
Regulation Mechanism			Transcription Factor Info
Fungicide
Tebuconazole	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tebuconazole inhibits the expression of SLC9A1		[25]
tebuconazole	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tebuconazole results in decreased expression of SLC9A1 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
Pesticide/Insecticide
Endosulfan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Endosulfan increases the expression of SLC9A1		[23]
Dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dicrotophos increases the expression of SLC9A1		[24]
Health and Environmental Toxicant
tris(1,3-dichloro-2-propyl)phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tris(1,3-dichloro-2-propyl)phosphate increases the expression of SLC9A1		[22]
Chemical Compound
DT Modulation1	Paclitaxel results in decreased activity of SLC9A1 protein		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Troglitazone results in decreased activity of SLC9A1 protein		[2]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Valproic Acid affects the expression of SLC9A1 mRNA		[55]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	ethylisopropylamiloride results in decreased activity of SLC9A1 protein which results in increased abundance of Doxorubicin		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	SLC9A1 protein results in decreased susceptibility to Doxorubicin		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Phloretin inhibits the reaction SLC9A1 protein alternative form affects the transport of Sodium co-treated with Lithium		[16]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Phloretin results in decreased activity of SLC9A1 protein		[16]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Phloretin results in decreased activity of SLC9A1 protein alternative form		[16]
Regulation Mechanism			Transcription Factor Info
Pentanal	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Pentanal inhibits the expression of SLC9A1		[21]
DT Modulation1	Benzo(a)pyrene results in decreased methylation of SLC9A1 exon		[37]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased methylation of SLC9A1 3' UTR		[37]
Regulation Mechanism			Transcription Factor Info
3-methylsulfonyl-4-piperidinobenzoyl guanidine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	3-methylsulfonyl-4-piperidinobenzoyl guanidine results in decreased activity of SLC9A1 protein		[29]
Regulation Mechanism			Transcription Factor Info
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid results in increased expression of SLC9A1 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
8-Bromo Cyclic Adenosine Monophosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SLC9A1 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
afimoxifene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	afimoxifene inhibits the reaction Estrogens results in decreased expression of SLC9A1 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in increased expression of SLC9A1 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
benzo(e)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene results in increased methylation of SLC9A1 intron		[33]
Regulation Mechanism			Transcription Factor Info
beta-methylcholine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	beta-methylcholine affects the expression of SLC9A1 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
bisphenol A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A affects the methylation of SLC9A1 gene		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bisphenol A results in increased expression of SLC9A1 protein		[26]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in decreased expression of SLC9A1 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased abundance of Cadmium which results in decreased expression of SLC9A1 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Cadmium Chloride results in increased expression of SLC9A1 mRNA		[41]
Regulation Mechanism			Transcription Factor Info
cariporide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cariporide results in decreased activity of SLC9A1 protein		[42]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC9A1 gene		[43]
Regulation Mechanism			Transcription Factor Info
Copper	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiosemicarbazones binds to Copper which results in increased expression of SLC9A1 protein		[44]
Regulation Mechanism			Transcription Factor Info
dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dicrotophos results in increased expression of SLC9A1 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
eniporide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	eniporide results in decreased activity of SLC9A1 protein		[42]
Regulation Mechanism			Transcription Factor Info
Estrogens	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	afimoxifene inhibits the reaction Estrogens results in decreased expression of SLC9A1 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Estrogens results in decreased expression of SLC9A1 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
ethylisopropylamiloride	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ethylisopropylamiloride results in decreased activity of SLC9A1 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	ethylisopropylamiloride results in decreased activity of SLC9A1 protein which results in increased abundance of Doxorubicin		[45]
Regulation Mechanism			Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	FR900359 results in decreased phosphorylation of SLC9A1 protein		[46]
Regulation Mechanism			Transcription Factor Info
licochalcone B	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	licochalcone B results in increased expression of SLC9A1 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
Lithium	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phloretin inhibits the reaction SLC9A1 protein alternative form affects the transport of Sodium co-treated with Lithium		[16]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	SLC9A1 protein alternative form affects the transport of Sodium co-treated with Lithium		[16]
Regulation Mechanism			Transcription Factor Info
Manganese	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC9A1 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC9A1 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
Methapyrilene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methapyrilene results in increased methylation of SLC9A1 intron		[33]
Regulation Mechanism			Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of SLC9A1 mRNA		[49]
Regulation Mechanism			Transcription Factor Info
Ozone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Air Pollutants results in increased abundance of Ozone which affects the expression of SLC9A1 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
pentanal	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	pentanal results in decreased expression of SLC9A1 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
Sodium	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phloretin inhibits the reaction SLC9A1 protein alternative form affects the transport of Sodium co-treated with Lithium		[16]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	SLC9A1 protein affects the transport of Sodium		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	SLC9A1 protein alternative form affects the transport of Sodium co-treated with Lithium		[16]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC9A1 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased expression of SLC9A1 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
Sodium Chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Resveratrol results in increased expression of SLC9A1 protein which results in increased uptake of Sodium Chloride		[18]
Regulation Mechanism			Transcription Factor Info
Sodium Selenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium Selenite results in increased expression of SLC9A1 mRNA		[53]
Regulation Mechanism			Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiram results in increased expression of SLC9A1 mRNA		[51]
Regulation Mechanism			Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of SLC9A1 mRNA		[54]
Regulation Mechanism			Transcription Factor Info
zinc chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	zinc chloride results in increased expression of SLC9A1 mRNA		[3]
Regulation Mechanism			Transcription Factor Info
zoniporide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	zoniporide results in decreased activity of SLC9A1 protein		[42]
Regulation Mechanism			Transcription Factor Info

References
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Detail Information of Exogenous Modulation

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