Modelled DT Structure
Method:homology modeling
Template PDB:6LI9_B
Identity:32.196%
Minimized Score:-1166.46 kcal/mol
Detail: Structure Info
Drug Transporter (DT) Information
| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0465 | ||||
| Gene Name | SLC7A13 | ||||
| Protein Name | Sodium-independent aspartate/glutamate transporter 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
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| Synonyms | AGT-1; AGT1; SLC7A13; Solute carrier family 7 member 13; X-amino acid transporter 2; XAT2 | ||||
| DT Family | Amino Acid-Polyamine-Organocation (APC) Family | ||||
| L-type Amino Acid Transporter (LAT) Family | |||||
| Tissue Specificity | Expressed in the kidney. | ||||
| Function | This transporter mediates the transport L-aspartate and L-glutamate in a sodium-independent manner. | ||||
| Endogenous Substrate(s) | Aspartate | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Sodium-independent aspartate/glutamate transporter 1 |
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(β) Cell Distribution Level of Sodium-independent aspartate/glutamate transporter 1 |
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(γ) Organelle Distribution Level of Sodium-independent aspartate/glutamate transporter 1 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Sodium-independent aspartate/glutamate transporter 1 |
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(γ) Transcriptional Regulation of Sodium-independent aspartate/glutamate transporter 1 |
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(δ) Epigenetic Regulation of Sodium-independent aspartate/glutamate transporter 1 |
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(ε) Exogenous Modulation of Sodium-independent aspartate/glutamate transporter 1 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Sodium-independent aspartate/glutamate transporter 1 |
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(β) Disease-specific Protein Abundances of Sodium-independent aspartate/glutamate transporter 1 |
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(γ) Species- and Tissue-specific DT Abundances |
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| Molecular Transporting Profile of This DT | |||||
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Full List of Drug(s) Transported by This DT |
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Approved Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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L-glutamic acid
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Approved | Drug Info | Schizophrenia | 6A20 | [1] |
| References | |||||
| 1 | Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):775-80. | ||||
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