Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0465 Transporter Info
Gene Name	SLC7A13
Transporter Name	Sodium-independent aspartate/glutamate transporter 1
Gene ID	157724
UniProt ID	Q8TCU3

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Mycotoxins
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 results in decreased methylation of SLC7A13 gene		[1]
Regulation Mechanism			Transcription Factor Info
Chemical Compound
Benzo(a)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene results in increased methylation of SLC7A13 promoter		[2]
Regulation Mechanism			Transcription Factor Info
Valproic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid results in decreased methylation of SLC7A13 gene		[3]
Regulation Mechanism			Transcription Factor Info

References
1	Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology. 2016 Mar 28;350-352:31-9.
2	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
3	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.