Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0465 Transporter Info
Gene Name SLC7A13
Transporter Name Sodium-independent aspartate/glutamate transporter 1
Gene ID
157724
UniProt ID
Q8TCU3

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CEBPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC7A13 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein alpha Transcription Factor Info

Tissue

 Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC7A13 gene, which in turn affects the expression or function of the drug transporter Sodium-independent aspartate/glutamate transporter 1.

      Class1.2: Basic helix-loop-helix factors

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        MYC 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC7A13 gene in embryonic stem cells condition [2]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Related DT Changes

 Up regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to activate the transcription of SLC7A13 gene in embryonic stem cells condition, which leads to an increased expression of the drug transporter Sodium-independent aspartate/glutamate transporter 1.

      Class1.3: Basic helix-span-helix factors

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        TFAP2C 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC7A13 gene [3]

TF Protein Name

 Transcription factor AP-2 gamma Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC7A13 gene, which in turn affects the expression or function of the drug transporter Sodium-independent aspartate/glutamate transporter 1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC7A13 gene [4]

TF Protein Name

 Androgen receptor Transcription Factor Info

Tissue

 Breast; Cervix; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Androgen receptor (AR) can directly bind to the SLC7A13 gene, which in turn affects the expression or function of the drug transporter Sodium-independent aspartate/glutamate transporter 1.

        ESR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC7A13 gene [1]

TF Protein Name

 Estrogen receptor Transcription Factor Info

Tissue

 Breast; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Estrogen receptor (ESR1) can directly bind to the SLC7A13 gene, which in turn affects the expression or function of the drug transporter Sodium-independent aspartate/glutamate transporter 1.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC7A13 gene in health condition [5]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC7A13 gene in health condition, which leads to an affected expression of the drug transporter Sodium-independent aspartate/glutamate transporter 1.

        NR2F2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC7A13 gene [3]

TF Protein Name

 COUP transcription factor 2 Transcription Factor Info

Tissue

 Breast; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 COUP transcription factor 2 (NR2F2) can directly bind to the SLC7A13 gene, which in turn affects the expression or function of the drug transporter Sodium-independent aspartate/glutamate transporter 1.

      Class2.3: C2H2 zinc finger factors

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        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC7A13 gene [6]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Foreskin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC7A13 gene, which in turn affects the expression or function of the drug transporter Sodium-independent aspartate/glutamate transporter 1.

        ZNF217 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC7A13 gene in breast cancer condition [7]

TF Protein Name

 Zinc finger protein 217 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of SLC7A13 gene in breast cancer condition, which leads to an affected expression of the drug transporter Sodium-independent aspartate/glutamate transporter 1.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

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        FOXM1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC7A13 gene in breast cancer condition [8]

TF Protein Name

 Forkhead box protein M1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of SLC7A13 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium-independent aspartate/glutamate transporter 1.

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC7A13 gene [3]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Tissue

 Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Forkhead box protein P1 (FOXP1) can directly bind to the SLC7A13 gene, which in turn affects the expression or function of the drug transporter Sodium-independent aspartate/glutamate transporter 1.

      Class3.7: ARID domain factors

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        ARID3A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC7A13 gene [4]

TF Protein Name

 AT-rich interactive domain-containing protein 3A Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the SLC7A13 gene, which in turn affects the expression or function of the drug transporter Sodium-independent aspartate/glutamate transporter 1.

TF Superclass6: Immunoglobulin fold

      Class6.4: Runt domain factors

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        RUNX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC7A13 gene in prostate cancer condition [9]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLC7A13 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Sodium-independent aspartate/glutamate transporter 1.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        NFIC 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC7A13 gene [6]

TF Protein Name

 Nuclear factor 1 C-type Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Nuclear factor 1 C-type (NFIC) can directly bind to the SLC7A13 gene, which in turn affects the expression or function of the drug transporter Sodium-independent aspartate/glutamate transporter 1.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One. 2009;4(11):e7839.
3 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-370. (ID:ENSG00000164893)
4 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
5 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
6 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
7 Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics. 2014;15(1):520.
8 FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index. Breast Cancer Res Treat. 2015;154(1):23-32.
9 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.

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