Modelled DT Structure
Method:homology modeling
Template PDB:6M17_A
Identity:46.01%
Minimized Score:-1377.55 kcal/mol
Detail: Structure Info
Drug Transporter (DT) Information
| General Information of DT | |||||
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| DT ID | DTD0453 | ||||
| Gene Name | SLC6A20 | ||||
| Protein Name | Sodium/imino-acid transporter 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
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| Synonyms | SIT1; SLC6A20; Sodium- and chloride-dependent transporter XTRP3; Solute carrier family 6 member 20; Transporter rB21A homolog; XT3; XTRP3 | ||||
| DT Family | Neurotransmitter:Sodium Symporter (NSS) Family ; | ||||
| Tissue Specificity | Kidney and small intestine. Expressed in theS3 segment of the proximal tubule. | ||||
| Function | This transporter mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids. Involved in the transport of glycine. | ||||
| Endogenous Substrate(s) | Cl-; Na+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Sodium/imino-acid transporter 1 |
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(β) Cell Distribution Level of Sodium/imino-acid transporter 1 |
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(γ) Organelle Distribution Level of Sodium/imino-acid transporter 1 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Sodium/imino-acid transporter 1 |
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(γ) Transcriptional Regulation of Sodium/imino-acid transporter 1 |
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(δ) Epigenetic Regulation of Sodium/imino-acid transporter 1 |
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(ε) Exogenous Modulation of Sodium/imino-acid transporter 1 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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(γ) Outward/inward-facing Conformation |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Sodium/imino-acid transporter 1 |
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(β) Disease-specific Protein Abundances of Sodium/imino-acid transporter 1 |
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(γ) Species- and Tissue-specific DT Abundances |
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| Molecular Transporting Profile of This DT | |||||
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Full List of Drug(s) Transported by This DT |
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Approved Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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Amino acids
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Approved | Drug Info | Nutritional deficiency | 5B7Z | [1] |
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Endogenous Metabolites (EMs) Handled by This DT |
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Endogenous Metabolites (EMs) |
Click to Show/Hide the Full List of EMs: 3 EMs in Total | ||||
| EM Name | PubChem CID | Detail | Experimental Material | Ref | |
| Glycine betaine | EM Info | Unclear experiment used for identifying this EM | [2] | ||
| L-pipecolic acid | EM Info | Unclear experiment used for identifying this EM | [2] | ||
| L-proline | EM Info | Unclear experiment used for identifying this EM | [2] | ||
| References | |||||
| 1 | The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2). Biochem J. 2006 Jan 1;393(Pt 1):421-30. | ||||
| 2 | Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus. J Biol Chem. 2011 Jun 3;286(22):19511-22. | ||||
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