Drug Transporter (DT) Information

General Information of DT
DT ID DTD0325
Gene Name SLC37A4
Protein Name Glucose-6-phosphate translocase
Gene ID
2542
UniProt ID
O43826
TCDB ID
2.A.1.4.5
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms G6PT; G6PT1; G6PT2; G6PT3; GSD1b; GSD1c; GSD1d; Glucose-5-phosphate transporter; Glucose-6-phosphate exchanger SLC37A4; PRO0685; SLC37A4; Solute carrier family 37 member 4; TRG-19; TRG19; Transformation-related gene 19 protein
DT Family Major Facilitator Superfamily (MFS)
Organophosphate:Pi Antiporter (OPA) Family
Tissue Specificity Mostly expressed in liver and kidney.
Function This inorganic phosphate and glucose-6-phosphate antiporter in the endoplasmic reticulum that transports cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction.
Endogenous Substrate(s) Phosphate; Glucose-6-phosphate
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Glucose-6-phosphate translocase
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Glucose-6-phosphate translocase
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Glucose-6-phosphate translocase
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Glucose-6-phosphate translocase
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Glucose-6-phosphate translocase
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Glucose-6-phosphate translocase
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Glucose-6-phosphate translocase
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Glucose-6-phosphate translocase
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Glucose-6-phosphate translocase
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Glucose-6-phosphate
 Phase 1 Drug Info High blood glucose 5C61.5 [1]
References
1 A novel mutation (A148V) in the glucose 6-phosphate translocase (SLC37A4) gene in a Korean patient with glycogen storage disease type 1b. J Korean Med Sci. 2005 Jun;20(3):499-501.

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