Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0325 Transporter Info
Gene Name	SLC37A4
Transporter Name	Glucose-6-phosphate translocase
Gene ID	2542
UniProt ID	O43826

Post-Translational Modification of This DT
Overview ofSLC37A4 Modification Sites with Functional and Structural Information
Sequence	M A A Q G Y G Y Y R T V I F S A M F G G Y S L Y Y F N R K T F S F V M P S L V E E I P L D K D D L G F I T S S Q S A A Y A I S K F V S G V L S D Q M S A R W L F S S G L L L V G L V N I F F A W S S T V P V F A A L W F L N G L A Q G L G W P P C G K V L R K W F E P S Q F G T W W A I L S T S M N L A G G L G P I L A T I L A Q S Y S W R S T L A L S G A L C V V V S F L C L L L I H N E P A D V G L R N L D P M P S E G K K G S L K E E S T L Q E L L L S P Y L W V L S T G Y L V V F G V K T C C T D W G Q F F L I Q E K G Q S A L V G S S Y M S A L E V G G L V G S I A A G Y L S D R A M A K A G L S N Y G N P R H G L L L F M M A G M T V S M Y L F R V T V T S D S P K L W I L V L G A V F G F S S Y G P I A L F G V I A N E S A P P N L C G T S H A I V G L M A N V G G F L A G L P F S T I A K H Y S W S T A F W V A E V I C A A S T A A F F L L R N I R T K M G R V S K K A E
PTM type	X-Phosphorylation X-Ubiquitination X: Amino Acid

Phosphorylation
Serine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	144
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC37A4 Serine 144 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[1]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	143
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC37A4 Threonine 143 has the potential to affect its expression or activity.
Ubiquitination
Lysine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC37A4			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	207
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC37A4 Lysine 207 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC37A4			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	290
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC37A4 Lysine 290 has the potential to affect its expression or activity.

References
1	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.
2	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.

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