Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0325 Transporter Info
Gene Name	SLC37A4
Transporter Name	Glucose-6-phosphate translocase
Gene ID	2542
UniProt ID	O43826

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Estradiol co-treated with Progesterone results in increased expression of SLC37A4 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Cisplatin co-treated with jinfukang results in increased expression of SLC37A4 mRNA		[7]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Valproic Acid results in increased expression of SLC37A4 mRNA		[48]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC37A4 promoter		[32]
Regulation Mechanism			Transcription Factor Info
2,3-bis(3'-hydroxybenzyl)butyrolactone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of SLC37A4 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid results in increased expression of SLC37A4 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLC37A4 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
Acrolein	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone affects the expression of SLC37A4 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which affects the expression of SLC37A4 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
alpha-pinene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone affects the expression of SLC37A4 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which affects the expression of SLC37A4 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
aristolochic acid I	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of SLC37A4 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	aristolochic acid I results in decreased expression of SLC37A4 protein		[30]
Regulation Mechanism			Transcription Factor Info
beta-Naphthoflavone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	beta-Naphthoflavone results in decreased expression of SLC37A4 protein		[33]
Regulation Mechanism			Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A affects the expression of SLC37A4 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
bufotalin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bufotalin results in decreased expression of SLC37A4 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC37A4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC37A4 gene		[36]
Regulation Mechanism			Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in decreased expression of SLC37A4 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
Copper	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in decreased expression of SLC37A4 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
Coumestrol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of SLC37A4 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
Decitabine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Decitabine inhibits the reaction Smoke results in decreased expression of SLC37A4 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
di-n-butylphosphoric acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	di-n-butylphosphoric acid affects the expression of SLC37A4 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
erucylphospho-N,N,N-trimethylpropylammonium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	erucylphospho-N,N,N-trimethylpropylammonium results in decreased expression of SLC37A4 mRNA		[41]
Regulation Mechanism			Transcription Factor Info
K 7174	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	K 7174 results in decreased expression of SLC37A4 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
Manganese	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	manganese chloride results in increased abundance of Manganese which results in increased expression of SLC37A4 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	manganese chloride results in increased abundance of Manganese which results in increased expression of SLC37A4 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
methacrylaldehyde	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone affects the expression of SLC37A4 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which affects the expression of SLC37A4 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methyleugenol results in decreased expression of SLC37A4 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
methylmercuric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in decreased expression of SLC37A4 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
NSC 689534	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in decreased expression of SLC37A4 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of SLC37A4 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
Ozone	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone affects the expression of SLC37A4 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which affects the expression of SLC37A4 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Volatile Organic Compounds co-treated with Ozone affects the expression of SLC37A4 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
Progesterone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Progesterone results in increased expression of SLC37A4 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLC37A4 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLC37A4 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
tert-Butylhydroperoxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tert-Butylhydroperoxide results in decreased expression of SLC37A4 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiram results in decreased expression of SLC37A4 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
Nanoparticle
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in decreased expression of SLC37A4 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Dexamethasone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dexamethasone increases the expression of SLC37A4		[1]
Regulation Mechanism	via enhancement of Glucocorticoid receptor (NR3C1)		Transcription Factor Info
Cell System	Rat hepatocellular carcinoma cells (H4-II-E)
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the expression of SLC37A4		[2]
Estradiol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the expression of SLC37A4		[3]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid increases the expression of SLC37A4		[4]
Rosiglitazone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Rosiglitazone inhibits the expression of SLC37A4		[5]
Carbamazepine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Carbamazepine affects the expression of SLC37A4		[6]
Cisplatin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cisplatin increases the expression of SLC37A4		[7]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Urethane inhibits the expression of SLC37A4		[8]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC37A4		[9]
Valproic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid inhibits the expression of SLC37A4		[10]
Temozolomide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Temozolomide increases the expression of SLC37A4		[11]
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the expression of SLC37A4		[12]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of SLC37A4		[13]
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide increases the expression of SLC37A4		[14]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC37A4		[15]
Drug in Phase 3 Trial
Curcumin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Curcumin inhibits the expression of SLC37A4		[16]
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A affects the expression of SLC37A4		[21]
Investigative Drug
Chlorogenic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Chlorogenic acid inhibits the activity of SLC37A4		[25]
Patented Pharmaceutical Agent
K-7174	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	K-7174 inhibits the expression of SLC37A4		[18]
GSK-J4	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	GSK-J4 inhibits the expression of SLC37A4		[20]
Natural Product
Methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methyleugenol inhibits the expression of SLC37A4		[22]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of SLC37A4		[24]
Traditional Medicine
Jinfukang	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Jinfukang increases the expression of SLC37A4		[7]
Mycotoxins
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the expression of SLC37A4		[17]
DT Modulation2	Aflatoxin B1 affects the expression of SLC37A4 protein		[3]
Regulation Mechanism			Transcription Factor Info
Acute Toxic Substance
Acrylamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrylamide inhibits the expression of SLC37A4		[23]
Carcinogen
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC37A4		[22]
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLC37A4 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
Cadmium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC37A4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Health and Environmental Toxicant
tris(1,3-dichloro-2-propyl)phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tris(1,3-dichloro-2-propyl)phosphate inhibits the expression of SLC37A4		[19]

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Detail Information of Exogenous Modulation

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