Drug Transporter (DT) Information

General Information of DT
DT ID DTD0319
Gene Name SLC36A2
Protein Name Proton-coupled amino acid transporter 2
Gene ID
153201
UniProt ID
Q495M3
TCDB ID
2.A.18.8.6
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms PAT2; Proton/amino acid transporter 2; SLC36A2; Solute carrier family 36 member 2; TRAMD1; Tramdorin-1
DT Family Amino Acid/Auxin Permease (AAAP) Family ;
Tissue Specificity Abundantly expressed in kidney and muscle.Expressed in the S1 segment of the proximal tubule close to theglomerulus.
Function This transporter involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine.
Endogenous Substrate(s) H+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Proton-coupled amino acid transporter 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Proton-coupled amino acid transporter 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Proton-coupled amino acid transporter 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Proton-coupled amino acid transporter 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Proton-coupled amino acid transporter 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Proton-coupled amino acid transporter 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Proton-coupled amino acid transporter 2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Proton-coupled amino acid transporter 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Proton-coupled amino acid transporter 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Cycloserine
 Approved Drug Info Dementia 6D8Z [1]
References
1 Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (Slc36a2). Br J Pharmacol. 2005 Jan;144(1):28-41.

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