Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0319 Transporter Info
Gene Name SLC36A2
Transporter Name Proton-coupled amino acid transporter 2
Gene ID
153201
UniProt ID
Q495M3
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Mycotoxins

  Aflatoxin B1

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Aflatoxin B1 results in increased methylation of SLC36A2 intron [3]

Regulation Mechanism

 Transcription Factor Info

  aflatoxin B2

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 aflatoxin B2 results in decreased methylation of SLC36A2 intron [3]

Regulation Mechanism

 Transcription Factor Info

Chemical Compound

  DT Modulation1

 Cisplatin co-treated with jinfukang results in increased expression of SLC36A2 mRNA [1]

Regulation Mechanism

 Transcription Factor Info

  Benzo(a)pyrene

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene affects the methylation of SLC36A2 intron [3]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Benzo(a)pyrene affects the methylation of SLC36A2 promoter [4]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Benzo(a)pyrene results in increased methylation of SLC36A2 3' UTR [4]

Regulation Mechanism

 Transcription Factor Info

  benzo(e)pyrene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 benzo(e)pyrene results in decreased methylation of SLC36A2 intron [3]

Regulation Mechanism

 Transcription Factor Info

  ferrous chloride

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ferrous chloride results in increased expression of SLC36A2 mRNA [5]

Regulation Mechanism

 Transcription Factor Info

  Methapyrilene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Methapyrilene results in decreased methylation of SLC36A2 intron [3]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Cisplatin

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cisplatin increases the expression of SLC36A2 [1]

Discontinued Drug

  NOX-200

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 NOX-200 inhibits the activity of SLC36A2 [2]

Investigative Drug

  5-Hydroxy-L-tryptophan

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 5-Hydroxy-L-tryptophan inhibits the activity of SLC36A2 [2]
References
1 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
2 Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta. 2011 Jan;1808(1):260-70.
3 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018;121:214-223.
4 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
5 Adaptive cellular response of the substantia nigra dopaminergic neurons upon age-dependent iron accumulation. Aging Cell. 2022;21(9):e13694.

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