Drug Information

General Information
Drug ID
DR00197
Drug Name
Cycloserine
Synonyms
(+)-4-Amino-3-isoxazolidinone; (+)-Cycloserine; (4R)-4-Amino-3-isoxazolidinone; (4R)-4-amino-1,2-oxazolidin-3-one; (4R)-4-aminoisoxazolidin-3-one; (R)-(+)-4-Amino-3-isoxazolidinone; (R)-(+)-Cycloserine; (R)-4-AMINO-ISOXAZOLIDIN-3-ONE; (R)-4-Amino-3-isoxazolidinone; (R)-4-Amino-3-isoxazolidone; (R)-Cycloserine; 3-Isoxazolidinone, 4-amino-, (+)-(8CI); 3-Isoxazolidinone, 4-amino-, (4R)-(9CI); 3-Isoxazolidinone, 4-amino-, (R); 3-Isoxazolidinone, 4-amino-, D; Alpha-Cycloserine; C 3909; C-9390; C-9400; Cicloserina; Cicloserina [INN-Spanish]; Cicloserina [Italian]; Closerin; Closina; Cyclo-D-serine; Cyclorin; Cycloserine (JP15/USP/INN); Cycloserine [INN:BAN:JAN]; Cycloserinum; Cycloserinum [INN-Latin]; D-(+)-Cycloserine; D-4-Amino-3-isossazolidone; D-4-Amino-3-isossazolidone [Italian]; D-4-amino-3-isoxazolidinone; D-4-amino-3-isoxazolidone; D-CS; D-amino-3-isoxazolidinone; D-cycloserine; DRG-0195; E-733-A; FA6C7F8B-D080-4EA3-978F-1ECFB5A29D09; Farmiserina; I-1431; K-300; Micoserina; Miroserina; Miroseryn; Novoserin; Orientomycin; Oxamicina; Oxamicina [Italian]; Oxamycin; PA 94; PA-94; R(+)-4-Amino-3-isoxazolidinone; R-(+)-Cycloserine; R-4-Amino-3-isoxazolidinone; RO-1-9213; SC-49088; Seromycin; Seromycin (TN); Tebemicina; Tisomycin; Wasserina
Drug Type
Small molecular drug
Indication Dementia [ICD11:6D8Z] Approved [1]
Tuberculosis [ICD11:1B1Z] Approved [1]
Therapeutic Class
Antiinfective Agents
Structure
3D MOL 2D MOL
Formula
C3H6N2O2
Canonical SMILES
C1C(C(=O)NO1)N
InChI
InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
InChIKey
DYDCUQKUCUHJBH-UWTATZPHSA-N
CAS Number
CAS 68-41-7
Pharmaceutical Properties Molecular Weight 102.09 Topological Polar Surface Area 64.4
Heavy Atom Count 7 Rotatable Bond Count 0
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
XLogP
-1.5
PubChem CID
6234
PubChem SID
10257 ,11110913 ,11110914 ,11110915 ,11112194 ,11112195 ,11335273 ,11360512 ,11363754 ,11366316 ,11368878 ,11371441 ,11374029 ,11377040 ,11461484 ,11467117 ,11468237 ,11483744 ,11486765 ,11487900 ,11490187 ,11492120 ,11494674 ,12014545 ,15170469 ,17404815 ,24277962 ,24858076 ,24892907 ,24892979 ,25622405 ,26611680 ,26679210 ,26719637 ,29214856 ,29225230 ,3139717 ,46386864 ,46392863 ,46506865 ,46507135 ,47216632 ,602895 ,7847941 ,7885338 ,7979010 ,8149277 ,8153915 ,829389 ,841629
ChEBI ID
ChEBI:40009
TTD Drug ID
D02WFK
DT(s) Transporting This Drug PAT1 Transporter Info Proton-coupled amino acid transporter 1 Substrate [2]
PAT2 Transporter Info Proton-coupled amino acid transporter 2 Substrate [3]
References
1 Cycloserine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1). J Cell Physiol. 2005 Aug;204(2):604-13.
3 Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (Slc36a2). Br J Pharmacol. 2005 Jan;144(1):28-41.

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