Drug Transporter (DT) Information

General Information of DT
DT ID DTD0239
Gene Name SLC27A2
Protein Name Very long-chain acyl-CoA synthetase
Gene ID
11001
UniProt ID
O14975
TCDB ID
4.C.1.1.5
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms ACSVL1; FACVL1; FATP-2; FATP2; Fatty acid transport protein 2; Fatty-acid-coenzyme A ligase, very long-chain 1; HsT17226; Long-chain-fatty-acid--CoA ligase; SLC27A2; Solute carrier family 27 member 2; THCA-CoA ligase; VLACS; VLCS; Very long-chain-fatty-acid-CoA ligase; hFACVL1
DT Family Fatty Acid Transporter (FAT) Family ;
Tissue Specificity Expressed in liver, kidney, placenta andpancreas.
Function This transporter convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation.
Endogenous Substrate(s) Fatty acids
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Very long-chain acyl-CoA synthetase
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Very long-chain acyl-CoA synthetase
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Very long-chain acyl-CoA synthetase
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Very long-chain acyl-CoA synthetase
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Very long-chain acyl-CoA synthetase
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Very long-chain acyl-CoA synthetase
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Very long-chain acyl-CoA synthetase
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Very long-chain acyl-CoA synthetase
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Very long-chain acyl-CoA synthetase
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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