Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0239 Transporter Info
Gene Name SLC27A2
Transporter Name Very long-chain acyl-CoA synthetase
Gene ID
11001
UniProt ID
O14975

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CREB1 

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       Transcriptional Phenomenon1

 Direct binding to SLC27A2 gene [1]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC27A2 gene, which in turn affects the expression or function of the drug transporter Very long-chain acyl-CoA synthetase.

      Class1.2: Basic helix-loop-helix factors

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        AHR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC27A2 gene in breast cancer condition [2]

TF Protein Name

 Aryl hydrocarbon receptor Transcription Factor Info

Affected Drug/Substrate

 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of SLC27A2 gene in breast cancer condition, which leads to an increased expression of the drug transporter Very long-chain acyl-CoA synthetase.

        ARNT 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC27A2 gene in breast cancer condition [2]

TF Protein Name

 Aryl hydrocarbon receptor nuclear translocator Transcription Factor Info

Affected Drug/Substrate

 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Aryl hydrocarbon receptor nuclear translocator (ARNT) has been reported to activate the transcription of SLC27A2 gene in breast cancer condition, which leads to an increased expression of the drug transporter Very long-chain acyl-CoA synthetase.

        MYC 

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       Transcriptional Phenomenon1

 Binding to SLC27A2 gene in embryonic stem cells condition [3]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of SLC27A2 gene in embryonic stem cells condition, which leads to an affected expression of the drug transporter Very long-chain acyl-CoA synthetase.

        SREBF1 

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       Transcriptional Phenomenon1

 Activation of SLC27A2 gene in obesity condition [4]

TF Protein Name

 Sterol regulatory element-binding protein 1 Transcription Factor Info

Affected Drug/Substrate

 Triheptanoin

Studied Phenotype

 Obesity [ICD11: 5B81]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6J mice

Detailed Description

 Sterol regulatory element-binding protein 1 (SREBF1) has been reported to activate the transcription of SLC27A2 gene in obesity condition, which leads to an increased expression of the drug transporter Very long-chain acyl-CoA synthetase.

      Class1.3: Basic helix-span-helix factors

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        TFAP2C 

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       Transcriptional Phenomenon1

 Activation of SLC27A2 gene in breast cancer condition [5]

TF Protein Name

 Transcription factor AP-2 gamma Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor AP-2 gamma (TFAP2C) has been reported to activate the transcription of SLC27A2 gene in breast cancer condition, which leads to an increased expression of the drug transporter Very long-chain acyl-CoA synthetase.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        HNF4A 

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       Transcriptional Phenomenon1

 Binding to SLC27A2 gene in health condition [6]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC27A2 gene in health condition, which leads to an affected expression of the drug transporter Very long-chain acyl-CoA synthetase.

        PPARA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC27A2 gene in health condition [7]

TF Protein Name

 Peroxisome proliferator-activated receptor alpha Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Intestine

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6 mice

Detailed Description

 Peroxisome proliferator-activated receptor alpha (PPARA) has been reported to activate the transcription of SLC27A2 gene in health condition, which leads to an increased expression of the drug transporter Very long-chain acyl-CoA synthetase.

        RXRA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC27A2 gene in pregnancy condition [8]

TF Protein Name

 Retinoic acid receptor RXR-alpha Transcription Factor Info

Affected Drug/Substrate

 Free fatty acids

Studied Phenotype

 Pregnancy [ICD11: JA00-JA2Z]

Tissue

 Placenta

Related DT Changes

 Down regulating

Experimental Material

 Human placenta cell isolates

Detailed Description

 Retinoic acid receptor RXR-alpha (RXRA) has been reported to repress the transcription of SLC27A2 gene in pregnancy condition, which leads to a decreased expression of the drug transporter Very long-chain acyl-CoA synthetase.

        VDR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC27A2 gene in leukemia condition [9]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Affected Drug/Substrate

 1,25(OH)2D3

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to activate the transcription of SLC27A2 gene in leukemia condition, which leads to an increased expression of the drug transporter Very long-chain acyl-CoA synthetase.

      Class2.3: C2H2 zinc finger factors

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        YY1 

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       Transcriptional Phenomenon1

 Binding to SLC27A2 gene in melanocyte deficiency condition [10]

TF Protein Name

 Transcriptional repressor protein YY1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcriptional repressor protein YY1 (YY1) has been reported to bind to the transcription of SLC27A2 gene in melanocyte deficiency condition, which leads to an affected expression of the drug transporter Very long-chain acyl-CoA synthetase.

        ZNF217 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC27A2 gene in breast cancer condition [11]

TF Protein Name

 Zinc finger protein 217 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of SLC27A2 gene in breast cancer condition, which leads to an affected expression of the drug transporter Very long-chain acyl-CoA synthetase.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

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        E2F1 

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       Transcriptional Phenomenon1

 Binding to SLC27A2 gene in MCF7 cells [12]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLC27A2 gene in MCF7 cells, which leads to an affected expression of the drug transporter Very long-chain acyl-CoA synthetase.

TF Superclass6: Immunoglobulin fold

      Class6.3: p53 domain factors

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        TP63 

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       Transcriptional Phenomenon1

 Binding to SLC27A2 gene in epithelial to mesenchymal transition condition [13]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC27A2 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Very long-chain acyl-CoA synthetase.

      Class6.5: T-Box factors

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        EOMES 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC27A2 gene in health condition [14]

TF Protein Name

 Eomesodermin homolog Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Eomesodermin homolog (EOMES) has been reported to activate the transcription of SLC27A2 gene in health condition, which leads to an increased expression of the drug transporter Very long-chain acyl-CoA synthetase.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-295. (ID:ENSG00000140284)
2 High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq. Toxicol Sci. 2012 Dec;130(2):349-61.
3 Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One. 2009;4(11):e7839.
4 Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice. Am J Physiol Gastrointest Liver Physiol. 2010 Oct;299(4):G855-66.
5 Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells. Genes Chromosomes Cancer. 2010;49(10):948-62.
6 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
7 PPARalpha agonists positively and negatively regulate the expression of several nutrient/drug transporters in mouse small intestine. Biol Pharm Bull. 2007 Nov;30(11):2185-90.
8 Peroxisome proliferator-activated receptor-gamma and retinoid X receptor signaling regulate fatty acid uptake by primary human placental trophoblasts. J Clin Endocrinol Metab. 2005 Jul;90(7):4267-75.
9 Characterization of genomic vitamin D receptor binding sites through chromatin looping and opening. PLoS One. 2014;9(4):e96184.
10 YY1 regulates melanocyte development and function by cooperating with MITF. PLoS Genet. 2012;8(5):e1002688.
11 Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics. 2014;15(1):520.
12 A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
13 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
14 Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 2011;25(3):238-50.

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