Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0239 Transporter Info
Gene Name	SLC27A2
Transporter Name	Very long-chain acyl-CoA synthetase
Gene ID	11001
UniProt ID	O14975

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Nanoparticle
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in increased expression of SLC27A2 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Methotrexate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methotrexate increases the expression of SLC27A2		[1]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the expression of SLC27A2		[2]
Isotretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Isotretinoin inhibits the expression of SLC27A2		[3]
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide increases the expression of SLC27A2		[4]
Hydrogen Peroxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide affects the expression of SLC27A2		[5]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zidovudine increases the expression of SLC27A2		[6]
Fenofibrate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Fenofibrate increases the expression of SLC27A2		[7]
Adefovir dipivoxil	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Adefovir dipivoxil inhibits the expression of SLC27A2		[8]
Cidofovir	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cidofovir inhibits the expression of SLC27A2		[8]
Rosiglitazone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Rosiglitazone inhibits the expression of SLC27A2		[8]
Calcitriol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Calcitriol increases the expression of SLC27A2		[9]
Rifampin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Rifampin increases the expression of SLC27A2		[10]
Olanzapine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Olanzapine increases the expression of SLC27A2		[11]
Phenobarbital	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenobarbital increases the expression of SLC27A2		[12]
Menadione	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Menadione affects the expression of SLC27A2		[5]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC27A2		[13]
Estradiol	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of SLC27A2		[14]
Valproic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of SLC27A2		[15]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of SLC27A2		[16]
Zoledronic Acid	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid inhibits the expression of SLC27A2		[8]
Acetaminophen	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC27A2		[17]
DT Modulation2	Acetaminophen affects the expression of SLC27A2 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
Drug in Phase 1 Trial
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the expression of SLC27A2		[20]
Nicotinic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nicotinic acid increases the expression of SLC27A2		[23]
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of SLC27A2		[24]
Investigative Drug
Coumestrol	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Coumestrol increases the expression of SLC27A2		[18]
Farnesol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Farnesol increases the expression of SLC27A2		[29]
Patented Pharmaceutical Agent
ICG-001	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ICG-001 increases the expression of SLC27A2		[25]
GW-4064	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	GW-4064 increases the expression of SLC27A2		[29]
GW-7647	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	GW-7647 increases the expression of SLC27A2		[29]
Natural Product
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of SLC27A2		[28]
Resveratrol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Coumestrol co-treated with Resveratrol results in increased expression of SLC27A2 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
Traditional Medicine
Jinfukang	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Jinfukang inhibits the expression of SLC27A2		[26]
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin inhibits the expression of SLC27A2		[21]
Mycotoxins
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 affects the expression of SLC27A2		[19]
DT Modulation2	Aflatoxin B1 results in decreased methylation of SLC27A2 intron		[37]
Regulation Mechanism			Transcription Factor Info
aflatoxin B2	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aflatoxin B2 results in decreased methylation of SLC27A2 intron		[37]
Regulation Mechanism			Transcription Factor Info
Carcinogen
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC27A2		[30]
Arsenic	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of SLC27A2 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLC27A2 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
Pesticide/Insecticide
Dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dicrotophos inhibits the expression of SLC27A2		[27]
Health and Environmental Toxicant
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid increases the expression of SLC27A2		[31]
Chemical Compound
DT Modulation1	SLC27A2 protein affects the susceptibility to Methotrexate		[53]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Rosiglitazone results in increased expression of SLC27A2 mRNA		[7]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Phenobarbital affects the expression of SLC27A2 mRNA		[61]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Estradiol affects the expression of SLC27A2 mRNA		[48]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Estradiol co-treated with TGFB1 protein results in decreased expression of SLC27A2 mRNA		[49]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Zoledronic Acid results in increased expression of SLC27A2 mRNA		[65]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Zoledronic Acid results in increased expression of SLC27A2 protein		[65]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of SLC27A2 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Coumestrol co-treated with Resveratrol results in increased expression of SLC27A2 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
Cupric oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cupric oxide inhibits the expression of SLC27A2		[22]
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC27A2 intron		[37]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene affects the methylation of SLC27A2 promoter		[40]
Regulation Mechanism			Transcription Factor Info
2,3-bis(3'-hydroxybenzyl)butyrolactone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of SLC27A2 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid results in increased expression of SLC27A2 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC27A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC27A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC27A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC27A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC27A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime co-treated with Oleic Acid results in increased expression of SLC27A2 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC27A2 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
8-Bromo Cyclic Adenosine Monophosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SLC27A2 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
abrine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLC27A2 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	abrine results in increased expression of SLC27A2 protein		[35]
Regulation Mechanism			Transcription Factor Info
adefovir dipivoxil	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	adefovir dipivoxil results in decreased expression of SLC27A2 mRNA		[8]
Regulation Mechanism			Transcription Factor Info
Amphotericin B	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Amphotericin B analog results in decreased expression of SLC27A2 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
belinostat	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC27A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
benzo(e)pyrene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene results in decreased methylation of SLC27A2 intron		[37]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	benzo(e)pyrene results in increased methylation of SLC27A2 polyA tail		[37]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in decreased expression of SLC27A2 mRNA		[8]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC27A2 gene		[41]
Regulation Mechanism			Transcription Factor Info
chloroacetaldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	chloroacetaldehyde results in decreased expression of SLC27A2 mRNA		[8]
Regulation Mechanism			Transcription Factor Info
chromium hexavalent ion	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	chromium hexavalent ion affects the expression of SLC27A2 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in decreased expression of SLC27A2 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
Copper	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in decreased expression of SLC27A2 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
cupric oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cupric oxide results in decreased expression of SLC27A2 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
Dactinomycin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dactinomycin co-treated with nutlin 3 results in increased secretion of SLC27A2 protein		[45]
Regulation Mechanism			Transcription Factor Info
Deoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Deoxycholic Acid inhibits the reaction SLC27A2 protein results in increased uptake of Fatty Acids		[46]
Regulation Mechanism			Transcription Factor Info
dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dicrotophos results in decreased expression of SLC27A2 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC27A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC27A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC27A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC27A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC27A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
epigallocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of SLC27A2 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
Ethanol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethanol co-treated with Folic Acid results in increased expression of SLC27A2 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
Folic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethanol co-treated with Folic Acid results in increased expression of SLC27A2 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
Glucose	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glucose co-treated with Palmitic Acid results in decreased expression of SLC27A2 mRNA		[51]
Regulation Mechanism			Transcription Factor Info
GW 4064	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	GW 4064 co-treated with Oleic Acid results in decreased expression of SLC27A2 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	GW 4064 results in increased expression of SLC27A2 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
GW 7647	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	GW 7647 co-treated with Oleic Acid results in increased expression of SLC27A2 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	GW 7647 results in increased expression of SLC27A2 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
ICG 001	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ICG 001 results in increased expression of SLC27A2 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
lead acetate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	lead acetate results in decreased expression of SLC27A2 mRNA		[52]
Regulation Mechanism			Transcription Factor Info
Manganese	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of SLC27A2 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of SLC27A2 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
mercuric bromide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC27A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
Methapyrilene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methapyrilene results in decreased methylation of SLC27A2 intron		[37]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Methapyrilene results in increased methylation of SLC27A2 polyA tail		[37]
Regulation Mechanism			Transcription Factor Info
Niacin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Niacin results in increased expression of SLC27A2 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
NSC 689534	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in decreased expression of SLC27A2 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
nutlin 3	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dactinomycin co-treated with nutlin 3 results in increased secretion of SLC27A2 protein		[45]
Regulation Mechanism			Transcription Factor Info
Okadaic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of SLC27A2 mRNA		[54]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Okadaic Acid results in increased expression of SLC27A2 protein		[54]
Regulation Mechanism			Transcription Factor Info
Oleic Acid	6 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime co-treated with Oleic Acid results in increased expression of SLC27A2 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	GW 4064 co-treated with Oleic Acid results in decreased expression of SLC27A2 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	GW 7647 co-treated with Oleic Acid results in increased expression of SLC27A2 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Oleic Acid co-treated with Palmitic Acid results in decreased expression of SLC27A2 mRNA		[55]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Oleic Acid results in increased expression of SLC27A2 mRNA		[56]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Tamoxifen promotes the reaction Oleic Acid results in increased expression of SLC27A2 mRNA		[56]
Regulation Mechanism			Transcription Factor Info
Oxygen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Oxygen deficiency results in decreased expression of SLC27A2 mRNA		[8]
Regulation Mechanism			Transcription Factor Info
Palmitic Acid	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glucose co-treated with Palmitic Acid results in decreased expression of SLC27A2 mRNA		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Oleic Acid co-treated with Palmitic Acid results in decreased expression of SLC27A2 mRNA		[55]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Palmitic Acid results in decreased expression of SLC27A2 mRNA		[57]
Regulation Mechanism			Transcription Factor Info
Panobinostat	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC27A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
p-Chloromercuribenzoic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC27A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	p-Chloromercuribenzoic Acid results in increased expression of SLC27A2 mRNA		[58]
Regulation Mechanism			Transcription Factor Info
perfluorodecanesulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluorodecanesulfonic acid results in increased expression of SLC27A2 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
perfluorooctane sulfonic acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid affects the expression of SLC27A2 mRNA		[60]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	perfluorooctane sulfonic acid results in increased expression of SLC27A2 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid results in increased expression of SLC27A2 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
potassium chromate(VI)	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of SLC27A2 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	potassium chromate(VI) results in decreased expression of SLC27A2 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	potassium chromate(VI) results in increased expression of SLC27A2 mRNA		[62]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLC27A2 mRNA		[52]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of SLC27A2 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLC27A2 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
Tamoxifen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tamoxifen promotes the reaction Oleic Acid results in increased expression of SLC27A2 mRNA		[56]
Regulation Mechanism			Transcription Factor Info
tert-Butylhydroperoxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tert-Butylhydroperoxide affects the expression of SLC27A2 mRNA		[5]
Regulation Mechanism			Transcription Factor Info
Tetrachlorodibenzodioxin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin results in decreased expression of SLC27A2 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Tetrachlorodibenzodioxin results in increased expression of SLC27A2 mRNA		[63]
Regulation Mechanism			Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiram results in decreased expression of SLC27A2 mRNA		[52]
Regulation Mechanism			Transcription Factor Info
trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	trichostatin A results in increased expression of SLC27A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
Vanadates	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vanadates results in decreased expression of SLC27A2 mRNA		[62]
Regulation Mechanism			Transcription Factor Info
Vitamin K 3	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vitamin K 3 affects the expression of SLC27A2 mRNA		[64]
Regulation Mechanism			Transcription Factor Info
Vorinostat	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC27A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info

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