General Information of Drug Transporter (DT)
DT ID DTD0239 Transporter Info
Gene Name SLC27A2
Transporter Name Very long-chain acyl-CoA synthetase
Gene ID
11001
UniProt ID
O14975
Epigenetic Regulations of This DT (EGR)

microRNA

  Unclear Phenotype

         11 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

let-7b directly targets SLC27A2 [ 1 ]

Epigenetic Type

microRNA Experiment Method Proteomics

miRNA Stemloop ID

let-7b miRNA Mature ID let-7b-5p

miRNA Sequence

UGAGGUAGUAGGUUGUGUGGUU

miRNA Target Type

Direct

Experimental Material

Human cervical cancer cell line (Hela)

  Epigenetic Phenomenon2

miR-155 directly targets SLC27A2 [ 1 ]

Epigenetic Type

microRNA Experiment Method Proteomics

miRNA Stemloop ID

miR-155 miRNA Mature ID miR-155-5p

miRNA Sequence

UUAAUGCUAAUCGUGAUAGGGGUU

miRNA Target Type

Direct

Experimental Material

Human cervical cancer cell line (Hela)

  Epigenetic Phenomenon3

miR-204 directly targets SLC27A2 [ 2 ]

Epigenetic Type

microRNA Experiment Method HITS-CLIP

miRNA Stemloop ID

miR-204 miRNA Mature ID miR-204-5p

miRNA Sequence

UUCCCUUUGUCAUCCUAUGCCU

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human

  Epigenetic Phenomenon4

miR-211 directly targets SLC27A2 [ 2 ]

Epigenetic Type

microRNA Experiment Method HITS-CLIP

miRNA Stemloop ID

miR-211 miRNA Mature ID miR-211-5p

miRNA Sequence

UUCCCUUUGUCAUCCUUCGCCU

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human

  Epigenetic Phenomenon5

miR-3184 directly targets SLC27A2 [ 2 ]

Epigenetic Type

microRNA Experiment Method HITS-CLIP

miRNA Stemloop ID

miR-3184 miRNA Mature ID miR-3184-3p

miRNA Sequence

AAAGUCUCGCUCUCUGCCCCUCA

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human

  Epigenetic Phenomenon6

miR-4287 directly targets SLC27A2 [ 2 ]

Epigenetic Type

microRNA Experiment Method HITS-CLIP

miRNA Stemloop ID

miR-4287 miRNA Mature ID miR-4287

miRNA Sequence

UCUCCCUUGAGGGCACUUU

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human

  Epigenetic Phenomenon7

miR-4469 directly targets SLC27A2 [ 2 ]

Epigenetic Type

microRNA Experiment Method HITS-CLIP

miRNA Stemloop ID

miR-4469 miRNA Mature ID miR-4469

miRNA Sequence

GCUCCCUCUAGGGUCGCUCGGA

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human

  Epigenetic Phenomenon8

miR-4685 directly targets SLC27A2 [ 2 ]

Epigenetic Type

microRNA Experiment Method HITS-CLIP

miRNA Stemloop ID

miR-4685 miRNA Mature ID miR-4685-3p

miRNA Sequence

UCUCCCUUCCUGCCCUGGCUAG

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human

  Epigenetic Phenomenon9

miR-6832 directly targets SLC27A2 [ 2 ]

Epigenetic Type

microRNA Experiment Method HITS-CLIP

miRNA Stemloop ID

miR-6832 miRNA Mature ID miR-6832-3p

miRNA Sequence

ACCCUUUUUCUCUUUCCCAG

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human

  Epigenetic Phenomenon10

miR-6867 directly targets SLC27A2 [ 2 ]

Epigenetic Type

microRNA Experiment Method HITS-CLIP

miRNA Stemloop ID

miR-6867 miRNA Mature ID miR-6867-3p

miRNA Sequence

CUCUCCCUCUUUACCCACUAG

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human

  Epigenetic Phenomenon11

miR-7113 directly targets SLC27A2 [ 2 ]

Epigenetic Type

microRNA Experiment Method HITS-CLIP

miRNA Stemloop ID

miR-7113 miRNA Mature ID miR-7113-3p

miRNA Sequence

CCUCCCUGCCCGCCUCUCUGCAG

miRNA Target Type

Direct

Experimental Material

Multiple cell lines of human

Methylation

  Brain neuroepithelial tumour

           1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Moderate hypomethylation of SLC27A2 in brain neuroepithelial tumour than that in healthy individual

Studied Phenotype

Brain neuroepithelial tumour [ICD-11:2A00.2Y]

The Methylation Level of Disease Section Compare with the Healthy Individual

p-value:1.37E-09; Fold-change:-0.270292311; Z-score:-5.395696556
DT methylation level in the diseased tissue of patients
DT methylation level in the normal tissue of healthy individuals
Please Click the above Thumbnail to View/Download
the Methylation Barchart for All Samples

  Cerebellar liponeurocytoma

           1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Moderate hypomethylation of SLC27A2 in cerebellar liponeurocytoma than that in healthy individual

Studied Phenotype

Cerebellar liponeurocytoma [ICD-11:2A00.0Y]

The Methylation Level of Disease Section Compare with the Healthy Individual

p-value:0.000900804; Fold-change:-0.294387044; Z-score:-3.728760186
DT methylation level in the diseased tissue of patients
DT methylation level in the normal tissue of healthy individuals
Please Click the above Thumbnail to View/Download
the Methylation Barchart for All Samples

  Chronic obstructive pulmonary disease

           1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Moderate hypomethylation of SLC27A2 in chronic obstructive pulmonary disease than that in healthy individual

Studied Phenotype

Chronic obstructive pulmonary disease [ICD-11:CA22]

The Methylation Level of Disease Section Compare with the Healthy Individual

p-value:0.014822483; Fold-change:-0.200085975; Z-score:-1.411901064
DT methylation level in the diseased tissue of patients
DT methylation level in the normal tissue of healthy individuals
Please Click the above Thumbnail to View/Download
the Methylation Barchart for All Samples

  Melanoma

           1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Moderate hypomethylation of SLC27A2 in melanoma than that in healthy individual

Studied Phenotype

Melanoma [ICD-11:2C30]

The Methylation Level of Disease Section Compare with the Healthy Individual

p-value:0.000750984; Fold-change:-0.228906794; Z-score:-1.776139934
DT methylation level in the diseased tissue of patients
DT methylation level in the normal tissue of healthy individuals
Please Click the above Thumbnail to View/Download
the Methylation Barchart for All Samples

  Melanocytoma

           1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

Significant hypomethylation of SLC27A2 in melanocytoma than that in healthy individual

Studied Phenotype

Melanocytoma [ICD-11:2F36.2]

The Methylation Level of Disease Section Compare with the Healthy Individual

p-value:5.50E-13; Fold-change:-0.558301839; Z-score:-9.443902786
DT methylation level in the diseased tissue of patients
DT methylation level in the normal tissue of healthy individuals
Please Click the above Thumbnail to View/Download
the Methylation Barchart for All Samples
References
1 Widespread changes in protein synthesis induced by microRNAs. Nature. 2008 Sep 4;455(7209):58-63.
2 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates. Genes Dev. 2013 Jul 15;27(14):1624-32.

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