Modelled DT Structure
Method:loop building
Template PDB:7CH1_A
Identity:100%
Minimized Score:-1836.566 kcal/mol
Detail: Structure Info
Drug Transporter (DT) Information
| General Information of DT | |||||
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| DT ID | DTD0237 | ||||
| Gene Name | SLC26A9 | ||||
| Protein Name | Anion transporter/exchanger protein 9 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
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| Synonyms | Solute carrier family 26 member 9; SLC26A9 | ||||
| DT Family | Sulfate Permease (SULP) Family ; | ||||
| Tissue Specificity | Predominantly expressed in lung at the luminal side of the bronchiolar and alveolar epithelium of lung. To a lower extent, also expressed in pancreas and prostate. | ||||
| Function | This DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport and also mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. | ||||
| Endogenous Substrate(s) | Anions | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Anion transporter/exchanger protein 9 |
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(β) Cell Distribution Level of Anion transporter/exchanger protein 9 |
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(γ) Organelle Distribution Level of Anion transporter/exchanger protein 9 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Anion transporter/exchanger protein 9 |
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(γ) Transcriptional Regulation of Anion transporter/exchanger protein 9 |
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(δ) Epigenetic Regulation of Anion transporter/exchanger protein 9 |
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(ε) Exogenous Modulation of Anion transporter/exchanger protein 9 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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(δ) Xenobiotics-regulated Structural Variability |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Anion transporter/exchanger protein 9 |
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(β) Disease-specific Protein Abundances of Anion transporter/exchanger protein 9 |
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(γ) Species- and Tissue-specific DT Abundances |
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| Molecular Transporting Profile of This DT | |||||
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Full List of Drug(s) Transported by This DT |
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Clinical Trial Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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Bicarbonate
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Phase 3 | Drug Info | Metabolic acidosis | 5C73 | [1] |
| References | |||||
| 1 | SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+. Am J Physiol Cell Physiol. 2005 Aug;289(2):C493-505. | ||||
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