Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0237 Transporter Info
Gene Name SLC26A9
Transporter Name Anion transporter/exchanger protein 9
Gene ID
115019
UniProt ID
Q7LBE3

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        ATF3 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC26A9 gene in glioblastoma multiforme condition [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) has been reported to repress the transcription of SLC26A9 gene in glioblastoma multiforme condition, which leads to a decreased expression of the drug transporter Anion transporter/exchanger protein 9.

       Transcriptional Phenomenon2

 Direct binding to SLC26A9 gene [2]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC26A9 gene, which in turn affects the expression or function of the drug transporter Anion transporter/exchanger protein 9.

        FOSL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC26A9 gene [3]

TF Protein Name

 Fos-related antigen 1 Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Fos-related antigen 1 (FOSL1) can directly bind to the SLC26A9 gene, which in turn affects the expression or function of the drug transporter Anion transporter/exchanger protein 9.

        JUNB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC26A9 gene [4]

TF Protein Name

 Transcription factor JunB Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor JunB (JUNB) can directly bind to the SLC26A9 gene, which in turn affects the expression or function of the drug transporter Anion transporter/exchanger protein 9.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TCF21 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC26A9 gene in coronary artery disease condition [5]

TF Protein Name

 Transcription factor 21 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 21 (TCF21) has been reported to bind to the transcription of SLC26A9 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Anion transporter/exchanger protein 9.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TFAP2C 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC26A9 gene in breast cancer condition [6]

TF Protein Name

 Transcription factor AP-2 gamma Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor AP-2 gamma (TFAP2C) has been reported to activate the transcription of SLC26A9 gene in breast cancer condition, which leads to an increased expression of the drug transporter Anion transporter/exchanger protein 9.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        GATA3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC26A9 gene in breast cancer condition [7]

TF Protein Name

 Trans-acting T-cell-specific transcription factor GATA-3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) has been reported to bind to the transcription of SLC26A9 gene in breast cancer condition, which leads to an affected expression of the drug transporter Anion transporter/exchanger protein 9.

        GATA4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC26A9 gene in gastric cancer condition [8]

TF Protein Name

 Transcription factor GATA-4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor GATA-4 (GATA4) has been reported to bind to the transcription of SLC26A9 gene in gastric cancer condition, which leads to an affected expression of the drug transporter Anion transporter/exchanger protein 9.

        GATA6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC26A9 gene in gastric cancer condition [8]

TF Protein Name

 Transcription factor GATA-6 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor GATA-6 (GATA6) has been reported to activate the transcription of SLC26A9 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Anion transporter/exchanger protein 9.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC26A9 gene [2]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLC26A9 gene, which in turn affects the expression or function of the drug transporter Anion transporter/exchanger protein 9.

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC26A9 gene [3]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Foreskin; Pancreatic ductal; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC26A9 gene, which in turn affects the expression or function of the drug transporter Anion transporter/exchanger protein 9.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC26A9 gene [4]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Colon; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC26A9 gene, which in turn affects the expression or function of the drug transporter Anion transporter/exchanger protein 9.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RBPJ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC26A9 gene in immortal lymphoblast cell lines (LCLs) condition [9]

TF Protein Name

 Recombining binding protein suppressor of hairless Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Recombining binding protein suppressor of hairless (RBPJ) has been reported to bind to the transcription of SLC26A9 gene in immortal lymphoblast cell lines (LCLs) condition, which leads to an affected expression of the drug transporter Anion transporter/exchanger protein 9.

      Class6.2: STAT domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC26A9 gene in glioblastoma multiforme condition [10]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to activate the transcription of SLC26A9 gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Anion transporter/exchanger protein 9.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC26A9 gene in health condition [11]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC26A9 gene in health condition, which leads to an affected expression of the drug transporter Anion transporter/exchanger protein 9.

      Class6.7: Grainyhead domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GRHL2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC26A9 gene [12]

TF Protein Name

 Grainyhead-like protein 2 homolog Transcription Factor Info

Tissue

 Breast; Bronchus; Ovary

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC26A9 gene, which in turn affects the expression or function of the drug transporter Anion transporter/exchanger protein 9.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC26A9 gene in human embryonic stem cells (hESCs) condition [13]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC26A9 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Anion transporter/exchanger protein 9.
References
1 In vivo RNAi screen for BMI1 targets identifies TGF-BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis. Cancer Cell. 2013;23(5):660-76.
2 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-403. (ID:ENSG00000174502)
3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
4 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
5 Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
6 Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells. Genes Chromosomes Cancer. 2010;49(10):948-62.
7 Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC Cancer. 2014;14:278.
8 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
9 Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A. 2011;108(36):14902-7.
10 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
11 Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes Dev. 2007;21(15):1882-94.
12 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
13 Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.

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