General Information of Drug Transporter (DT)
DT ID	DTD0237 Transporter Info
Gene Name	SLC26A9
Protein Name	Anion transporter/exchanger protein 9
Gene ID	115019
UniProt ID	Q7LBE3
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs7512462
Site of GPD	chr1:205930467 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	T>C
Minor Allele Frequency	C=0.3650/1828 (Global)
Genotypes CC + CT	Click to Show/Hide the Full List of Affected Drugs:           3 Drugs in Total
Ivacaftor	Drug Info	Cystic Fibrosis	Correlated with the increased drug response in patients (compare with Genotype TT)		[ 1]
Ivacaftor	N.A.	Hypertension	Genotypes CC + CT is associated with increased response to ivacaftor in children with Cystic Fibrosis as compared to genotype TT.		[ 1]
Ivacaftor	N.A.	Cystic Fibrosis	Genotypes CC + CT is associated with increased response to ivacaftor in children with Cystic Fibrosis as compared to genotype TT.		[ 1]
Genotype CC	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Ivacaftor	N.A.	Cystic Fibrosis	Children with the CC genotype and gating mutations in cystic fibrosis may have increased response to ivacaftor compared to children with the CT or TT genotypes. Other clinical and genetic factors may affect response to ivacaftor.		[ 1]
Genotype CT	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Ivacaftor	N.A.	Cystic Fibrosis	Children with the CT genotype and gating mutations in cystic fibrosis may have increased response to ivacaftor compared to children with the TT genotypes. Other clinical and genetic factors may affect response to ivacaftor.		[ 1]
Genotype TT	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Ivacaftor	N.A.	Cystic Fibrosis	Children with the TT genotype and gating mutations in cystic fibrosis may have decreased response to ivacaftor compared to children with the CC or CT genotypes. Other clinical and genetic factors may affect response to ivacaftor.		[ 1]
Genetic Polymorphism	rs11240594
Site of GPD	chr1:205927107 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A
Minor Allele Frequency	G=0.7190/1422 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Olanzapine	N.A.	Hypertension	Allele A is associated with increased response to olanzapine in people with Schizophrenia as compared to allele G.		[ 2]
References
1	Cystic fibrosis gene modifier SLC26A9 modulates airway response to CFTR-directed therapeutics. Hum Mol Genet. 2016 Oct 15;25(20):4590-4600.
2	Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. Neuropsychopharmacology. 2011 Feb;36(3):616-26.

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