Drug Transporter (DT) Information

General Information of DT
DT ID DTD0191
Gene Name SLC25A3
Protein Name Phosphate carrier protein
Gene ID
5250
UniProt ID
Q00325
TCDB ID
2.A.29.4.2
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms OK/SW-cl.48; PHC; PTP; Phosphate transport protein; SLC25A3; Solute carrier family 25 member 3
DT Family Mitochondrial Carrier (MC) Family ;
Function This transporter mediates the transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP).
Endogenous Substrate(s) Phosphate
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Phosphate carrier protein
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Phosphate carrier protein
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Phosphate carrier protein
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Phosphate carrier protein
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Phosphate carrier protein
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Phosphate carrier protein
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Phosphate carrier protein
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Phosphate carrier protein
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Phosphate carrier protein
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Phosphate
 Approved Drug Info Constipation ME05.0 [1]
References
1 The mammalian phosphate carrier SLC25A3 is a mitochondrial copper transporter required for cytochrome c oxidase biogenesis. J Biol Chem. 2018 Feb 9;293(6):1887-1896.

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