Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0191 Transporter Info
Gene Name SLC25A3
Transporter Name Phosphate carrier protein
Gene ID
5250
UniProt ID
Q00325

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        ATF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A3 gene [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-1 Transcription Factor Info

Tissue

 Bone marrow; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-1 (ATF1) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A3 gene [2]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Tissue

 Bone marrow; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A3 gene [3]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Bone

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

        CREB1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC25A3 gene in health condition [4]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) has been reported to activate the transcription of SLC25A3 gene in health condition, which leads to an increased expression of the drug transporter Phosphate carrier protein.

       Transcriptional Phenomenon2

 Direct binding to SLC25A3 gene [5]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Bone marrow; Colon; Embryo; Liver; Lung; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

        FOSL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A3 gene [1]

TF Protein Name

 Fos-related antigen 1 Transcription Factor Info

Tissue

 Breast; Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Fos-related antigen 1 (FOSL1) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

        JUND 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A3 gene [2]

TF Protein Name

 Transcription factor JunD Transcription Factor Info

Tissue

 Bone marrow; Brain; Cervix; Colon; Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor JunD (JUND) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC25A3 gene in castration-resistant prostate cancers condition [6]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Androgen receptor (AR) has been reported to activate the transcription of SLC25A3 gene in castration-resistant prostate cancers condition, which leads to an increased expression of the drug transporter Phosphate carrier protein.

        VDR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A3 gene in health condition [7]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to bind to the transcription of SLC25A3 gene in health condition, which leads to an affected expression of the drug transporter Phosphate carrier protein.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A3 gene [1]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Erythroid transcription factor (GATA1) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

        GATA3 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A3 gene in breast cancer condition [8]

TF Protein Name

 Trans-acting T-cell-specific transcription factor GATA-3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) has been reported to bind to the transcription of SLC25A3 gene in breast cancer condition, which leads to an affected expression of the drug transporter Phosphate carrier protein.

       Transcriptional Phenomenon2

 Direct binding to SLC25A3 gene [2]

TF Protein Name

 Trans-acting T-cell-specific transcription factor GATA-3 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A3 gene [5]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Colon; Pancreatic ductal; Stomach

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A3 gene [3]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A3 gene [3]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Tissue

 Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F1 (E2F1) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

        E2F4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A3 gene in health condition [9]

TF Protein Name

 Transcription factor E2F4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F4 (E2F4) has been reported to bind to the transcription of SLC25A3 gene in health condition, which leads to an affected expression of the drug transporter Phosphate carrier protein.

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A3 gene [2]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Embryo; Liver; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A3 gene [3]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Embryo; Endoderm; Liver; Lung; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A3 gene [5]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A3 gene [1]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney; Prostate; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

        ETS2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A3 gene [1]

TF Protein Name

 Protein C-ets-2 Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-2 (ETS2) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

        FLI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A3 gene in megakaryocytes condition [10]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC25A3 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Phosphate carrier protein.

       Transcriptional Phenomenon2

 Direct binding to SLC25A3 gene [2]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A3 gene [3]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Breast; Cervix; Liver; Lung; Mesenchymal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A3 gene [5]

TF Protein Name

 Interferon regulatory factor 1 Transcription Factor Info

Tissue

 Bone marrow; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 1 (IRF1) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        EBF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A3 gene [5]

TF Protein Name

 Transcription factor COE1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor COE1 (EBF1) can directly bind to the SLC25A3 gene, which in turn affects the expression or function of the drug transporter Phosphate carrier protein.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A3 gene in megakaryocytes condition [10]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC25A3 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Phosphate carrier protein.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-162. (ID:ENSG00000075415)
2 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4 Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A. 2005;102(12):4459-64.
5 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
6 Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer. Oncogene. 2012;31(17):2153-63.
7 Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease. BMC Med. 2013;11:163.
8 Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC Cancer. 2014;14:278.
9 Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis. Nucleic Acids Res. 2011;39(9):3558-73.
10 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.

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