Drug Transporter (DT) Information

General Information of DT
DT ID DTD0175
Gene Name SLC25A16
Protein Name Graves disease carrier protein
Gene ID
8034
UniProt ID
P16260
TCDB ID
2.A.29.12.3
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms D10S105E; GDA; GDC; Graves disease autoantigen; HGT.1; ML7; SLC25A16; Solute carrier family 25 member 16; hML7; Mitochondrial solute carrier protein homolog
DT Family Mitochondrial Carrier (MC) Family ;
Function This transporter required for the accumulation of coenzyme A in the mitochondrial matrix.
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Graves disease carrier protein
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Graves disease carrier protein
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Graves disease carrier protein
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Graves disease carrier protein
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Graves disease carrier protein
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Graves disease carrier protein
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Graves disease carrier protein
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Graves disease carrier protein
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Graves disease carrier protein
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Coenzyme A
 Phase 3 Drug Info Hyperlipoproteinemia 5C80 [1]

Drug-DT Affinity Assessed by Cell Line

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           3 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
Coenzyme A Phase 3 Drug Info Yeast cells-GDC Km =140 microM [1]
Coenzyme A Phase 3 Drug Info Yeast cells-GDC Km =140 microM [1]
Coenzyme A Phase 3 Drug Info Yeast cells-GDC Km =140 microM [1]
References
1 Biochemical characterization of a new mitochondrial transporter of dephosphocoenzyme A in Drosophila melanogaster. Biochim Biophys Acta Bioenerg. 2017 Feb;1858(2):137-146.

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