Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0175 Transporter Info
Gene Name SLC25A16
Transporter Name Graves disease carrier protein
Gene ID
8034
UniProt ID
P16260

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Tissue

 Blood; Bone marrow; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

        CEBPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [2]

TF Protein Name

 CCAAT/enhancer-binding protein alpha Transcription Factor Info

Tissue

 Blood; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [3]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Bone

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [4]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Bone marrow; Embryo; Liver; Lung; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        MITF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC25A16 gene in melanoma condition [5]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC25A16 gene in melanoma condition, which leads to an increased expression of the drug transporter Graves disease carrier protein.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [2]

TF Protein Name

 Androgen receptor Transcription Factor Info

Tissue

 Breast; Cervix; Kidney; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Androgen receptor (AR) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A16 gene in health condition [6]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC25A16 gene in health condition, which leads to an affected expression of the drug transporter Graves disease carrier protein.

        VDR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A16 gene in health condition [7]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to bind to the transcription of SLC25A16 gene in health condition, which leads to an affected expression of the drug transporter Graves disease carrier protein.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [2]

TF Protein Name

 Trans-acting T-cell-specific transcription factor GATA-3 Transcription Factor Info

Tissue

 Blood; Brain; Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        KLF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [3]

TF Protein Name

 Krueppel-like factor 1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 1 (KLF1) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [4]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Breast; Foreskin; Pancreatic ductal; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

        KLF5 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC25A16 gene in gastric cancer condition [8]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Krueppel-like factor 5 (KLF5) has been reported to activate the transcription of SLC25A16 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Graves disease carrier protein.

       Transcriptional Phenomenon2

 Direct binding to SLC25A16 gene [3]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Colon; Pancreatic ductal; Stomach

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [1]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

        MECOM 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [4]

TF Protein Name

 Histone-lysine N-methyltransferase MECOM Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Histone-lysine N-methyltransferase MECOM (MECOM) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        CDX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene in health condition [9]

TF Protein Name

 Homeobox protein CDX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Homeobox protein CDX-2 (CDX2) has been reported to bind to the transcription of SLC25A16 gene in health condition, which leads to an affected expression of the drug transporter Graves disease carrier protein.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [1]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Tissue

 Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F1 (E2F1) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

        E2F4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A16 gene in health condition [10]

TF Protein Name

 Transcription factor E2F4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F4 (E2F4) has been reported to bind to the transcription of SLC25A16 gene in health condition, which leads to an affected expression of the drug transporter Graves disease carrier protein.

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [4]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Liver; Pancreatic ductal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [1]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Embryo; Liver; Lung; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC25A16 gene in health condition [11]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of SLC25A16 gene in health condition, which leads to a decreased expression of the drug transporter Graves disease carrier protein.

        FOXP2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A16 gene [12]

TF Protein Name

 Forkhead box protein P2 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Forkhead box protein P2 (FOXP2) has been reported to bind to the transcription of SLC25A16 gene in . condition, which leads to an affected expression of the drug transporter Graves disease carrier protein.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [2]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [3]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney; Prostate; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [3]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [4]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [2]

TF Protein Name

 Interferon regulatory factor 1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 1 (IRF1) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A16 gene in acute promyelocytic leukemia condition [13]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC25A16 gene in acute promyelocytic leukemia condition, which leads to an affected expression of the drug transporter Graves disease carrier protein.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        STAT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [14]

TF Protein Name

 Signal transducer and activator of transcription 1-alpha/beta Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 1-alpha/beta (STAT1) has been reported to bind to the transcription of SLC25A16 gene in . condition, which leads to a affected expression of the drug transporter Graves disease carrier protein.

TF Superclass10: Yet undefined DNA-binding domains

      Class10.1: Other factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GTF2B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A16 gene [1]

TF Protein Name

 Transcription initiation factor IIB Transcription Factor Info

Tissue

 Cervix; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription initiation factor IIB (GTF2B) can directly bind to the SLC25A16 gene, which in turn affects the expression or function of the drug transporter Graves disease carrier protein.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-246. (ID:ENSG00000122912)
2 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
5 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
6 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
7 Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease. BMC Med. 2013;11:163.
8 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
9 Genome-wide analysis of CDX2 binding in intestinal epithelial cells (Caco-2). J Biol Chem. 2010;285(33):25115-25.
10 Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis. Nucleic Acids Res. 2011;39(9):3558-73.
11 An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
12 Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets. Nucleic Acids Res. 2013;41(12):5991-6004.
13 Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia. J Hematol Oncol. 2013;6:25.
14 MER41 repeat sequences contain inducible STAT1 binding sites. PLoS One. 2010;5(7):e11425.

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