Drug Transporter (DT) Information

General Information of DT
DT ID DTD0172
Gene Name SLC25A14
Protein Name Brain mitochondrial carrier protein 1
Gene ID
9016
UniProt ID
O95258
TCDB ID
2.A.29.24.1
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:2LCK_A

Identity:38.112%

Minimized Score:-456.39 kcal/mol

Detail: Structure Info

Synonyms BMCP-1; BMCP1; Mitochondrial uncoupling protein 5; SLC25A14; Solute carrier family 25 member 14; UCP 5; UCP5; UNQ791/PRO1682
DT Family Mitochondrial Carrier (MC) Family ;
Tissue Specificity Mainly expressed in brain. Some expression intestis and pituitary.
Function This transporter participates in the mitochondrial proton leak measured in brain mitochondria.
Endogenous Substrate(s) H+; Cl-
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Brain mitochondrial carrier protein 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Brain mitochondrial carrier protein 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Brain mitochondrial carrier protein 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Brain mitochondrial carrier protein 1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Brain mitochondrial carrier protein 1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Brain mitochondrial carrier protein 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Brain mitochondrial carrier protein 1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Brain mitochondrial carrier protein 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Brain mitochondrial carrier protein 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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