Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0172 Transporter Info | ||||
| Gene Name | SLC25A14 | ||||
| Protein Name | Brain mitochondrial carrier protein 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs2239483 | ||||
| Site of GPD | chrX:130343477 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | A>G | ||||
| Minor Allele Frequency | A=0.6710/1327 (Global) | ||||
| Allele G | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Antipsychotics | N.A. | Diarrhea | Allele G is not associated with ultra-resistance when treated with antipsychotics in people with Schizophrenia as compared to allele A. | [ 1] | |
| Genetic Polymorphism | rs5977250 | ||||
| Site of GPD | chrX:130372418 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | T>A / T>C | ||||
| Minor Allele Frequency | T=0.6130/1213 (Global) | ||||
| Allele C | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Antipsychotics | N.A. | Diarrhea | Allele C is not associated with ultra-resistance when treated with antipsychotics in people with Schizophrenia as compared to allele T. | [ 1] | |
| Genetic Polymorphism | rs2235800 | ||||
| Site of GPD | chrX:130364862 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | T>A / T>C | ||||
| Minor Allele Frequency | T=0.6190/1225 (Global) | ||||
| Allele A | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Antipsychotics | N.A. | Diarrhea | Allele A is not associated with ultra-resistance when treated with antipsychotics in people with Schizophrenia as compared to allele T. | [ 1] | |
| Genetic Polymorphism | rs1010978 | ||||
| Site of GPD | chrX:130345486 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | T>C / T>G | ||||
| Minor Allele Frequency | T=0.6650/1316 (Global) | ||||
| Allele C | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Antipsychotics | N.A. | Diarrhea | Allele C is not associated with ultra-resistance when treated with antipsychotics in people with Schizophrenia as compared to allele T. | [ 1] | |
| References | |||||
| 1 | Association of an UCP4 (SLC25A27) haplotype with ultra-resistant schizophrenia. Pharmacogenomics. 2011 Feb;12(2):185-93. | ||||
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