Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0172 Transporter Info
Gene Name SLC25A14
Transporter Name Brain mitochondrial carrier protein 1
Gene ID
9016
UniProt ID
O95258

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A14 gene [1]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC25A14 gene, which in turn affects the expression or function of the drug transporter Brain mitochondrial carrier protein 1.

      Class1.2: Basic helix-loop-helix factors

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        MAX 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A14 gene [2]

TF Protein Name

 Protein max Transcription Factor Info

Tissue

 Blood; Bone marrow; Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein max (MAX) can directly bind to the SLC25A14 gene, which in turn affects the expression or function of the drug transporter Brain mitochondrial carrier protein 1.

        MYOD1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A14 gene [3]

TF Protein Name

 Myoblast determination protein 1 Transcription Factor Info

Tissue

 Myotube

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myoblast determination protein 1 (MYOD1) can directly bind to the SLC25A14 gene, which in turn affects the expression or function of the drug transporter Brain mitochondrial carrier protein 1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.3: C2H2 zinc finger factors

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        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A14 gene [3]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC25A14 gene, which in turn affects the expression or function of the drug transporter Brain mitochondrial carrier protein 1.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 3 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A14 gene in health condition [4]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLC25A14 gene in health condition, which leads to an affected expression of the drug transporter Brain mitochondrial carrier protein 1.

       Transcriptional Phenomenon2

 Binding to SLC25A14 gene in health condition [5]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLC25A14 gene in health condition, which leads to an affected expression of the drug transporter Brain mitochondrial carrier protein 1.

       Transcriptional Phenomenon3

 Direct binding to SLC25A14 gene [6]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Tissue

 Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F1 (E2F1) can directly bind to the SLC25A14 gene, which in turn affects the expression or function of the drug transporter Brain mitochondrial carrier protein 1.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A14 gene [1]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC25A14 gene, which in turn affects the expression or function of the drug transporter Brain mitochondrial carrier protein 1.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A14 gene [3]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC25A14 gene, which in turn affects the expression or function of the drug transporter Brain mitochondrial carrier protein 1.

        FLI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A14 gene in megakaryocytes condition [7]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC25A14 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Brain mitochondrial carrier protein 1.

       Transcriptional Phenomenon2

 Direct binding to SLC25A14 gene [6]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC25A14 gene, which in turn affects the expression or function of the drug transporter Brain mitochondrial carrier protein 1.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A14 gene [1]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Brain; Breast; Cervix; Embryo; Liver; Lung; Mesenchymal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC25A14 gene, which in turn affects the expression or function of the drug transporter Brain mitochondrial carrier protein 1.

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A14 gene [2]

TF Protein Name

 Interferon regulatory factor 1 Transcription Factor Info

Tissue

 Bone marrow; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 1 (IRF1) can directly bind to the SLC25A14 gene, which in turn affects the expression or function of the drug transporter Brain mitochondrial carrier protein 1.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.1: High-mobility group domain factors

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        SOX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC25A14 gene in colorectal cancer condition [8]

TF Protein Name

 Transcription factor SOX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of SLC25A14 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Brain mitochondrial carrier protein 1.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-190. (ID:ENSG00000102078)
2 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
4 A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
5 Genome-wide analysis of transcription factor E2F1 mutant proteins reveals that N- and C-terminal protein interaction domains do not participate in targeting E2F1 to the human genome. J Biol Chem. 2011;286(14):11985-96.
6 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
7 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
8 ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS. 2010;14(4):369-84.

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