Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0172 Transporter Info
Gene Name SLC25A14
Transporter Name Brain mitochondrial carrier protein 1
Gene ID
9016
UniProt ID
O95258
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 Dactinomycin inhibits the reaction Dopamine results in increased expression of SLC25A14 mRNA [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 SLC25A14 protein inhibits the reaction Dopamine results in increased abundance of Superoxides [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 SLC25A14 protein results in decreased susceptibility to Dopamine [1]

Regulation Mechanism

 Transcription Factor Info

  1-Methyl-4-phenylpyridinium

            7 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 1-Methyl-4-phenylpyridinium results in increased expression of SLC25A14 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 1-Methyl-4-phenylpyridinium results in increased expression of SLC25A14 protein [11]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Dactinomycin inhibits the reaction 1-Methyl-4-phenylpyridinium results in increased expression of SLC25A14 mRNA [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 LEP protein promotes the reaction 1-Methyl-4-phenylpyridinium results in increased expression of SLC25A14 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation5

 SLC25A14 protein inhibits the reaction 1-Methyl-4-phenylpyridinium results in increased abundance of Superoxides [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation6

 SLC25A14 protein results in decreased susceptibility to 1-Methyl-4-phenylpyridinium [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation7

 UCP2 protein inhibits the reaction 1-Methyl-4-phenylpyridinium results in increased expression of SLC25A14 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  Adenosine Triphosphate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 SLC25A14 protein results in decreased chemical synthesis of Adenosine Triphosphate [1]

Regulation Mechanism

 Transcription Factor Info

  Benzo(a)pyrene

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene affects the methylation of SLC25A14 5' UTR [13]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Benzo(a)pyrene affects the methylation of SLC25A14 promoter [13]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Benzo(a)pyrene results in decreased methylation of SLC25A14 3' UTR [13]

Regulation Mechanism

 Transcription Factor Info

  Dactinomycin

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Dactinomycin inhibits the reaction 1-Methyl-4-phenylpyridinium results in increased expression of SLC25A14 mRNA [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Dactinomycin inhibits the reaction Dopamine results in increased expression of SLC25A14 mRNA [1]

Regulation Mechanism

 Transcription Factor Info

  di-n-butylphosphoric acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 di-n-butylphosphoric acid affects the expression of SLC25A14 mRNA [14]

Regulation Mechanism

 Transcription Factor Info

  Methyl Methanesulfonate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Methyl Methanesulfonate results in increased expression of SLC25A14 mRNA [15]

Regulation Mechanism

 Transcription Factor Info

  Okadaic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Okadaic Acid results in increased expression of SLC25A14 mRNA [16]

Regulation Mechanism

 Transcription Factor Info

  O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 PON1 gene polymorphism affects the susceptibility to O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of SLC25A14 mRNA [17]

Regulation Mechanism

 Transcription Factor Info

  triphenyl phosphate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 triphenyl phosphate affects the expression of SLC25A14 mRNA [14]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Dopamine

            4 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Dopamine increases the expression of SLC25A14 [1]

  Cyclosporine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cyclosporine inhibits the expression of SLC25A14 [2]

  Acetaminophen

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acetaminophen increases the expression of SLC25A14 [3]

  Valproic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Valproic Acid affects the expression of SLC25A14 [4]

  Cisplatin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cisplatin increases the expression of SLC25A14 [5]

  Doxorubicin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Doxorubicin inhibits the expression of SLC25A14 [6]

  Leflunomide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Leflunomide inhibits the expression of SLC25A14 [7]

Drug in Phase 3 Trial

  Fenretinide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Fenretinide increases the expression of SLC25A14 [8]

Natural Product

  Tobacco Smoke Pollution

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tobacco Smoke Pollution inhibits the expression of SLC25A14 [10]

Health and Environmental Toxicant

  1-methyl-4-phenylpyridinium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 1-methyl-4-phenylpyridinium increases the expression of SLC25A14 [1]

Herbicide

  Atrazine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Atrazine inhibits the expression of SLC25A14 [9]
References
1 Mitochondrial UCP5 is neuroprotective by preserving mitochondrial membrane potential, ATP levels, and reducing oxidative stress in MPP+ and dopamine toxicity. Free Radic Biol Med. 2010 Sep 15;49(6):1023-35.
2 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
3 Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
4 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20.
5 Low Doses of Cisplatin Induce Gene Alterations, Cell Cycle Arrest, and Apoptosis in Human Promyelocytic Leukemia Cells. Biomark Insights. 2016 Aug 24;11:113-21.
6 Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
7 Mitochondrial dysfunction induced by leflunomide and its active metabolite. Toxicology. 2018 Mar 1;396-397:33-45.
8 4-HPR modulates gene expression in ovarian cells. Int J Cancer. 2006 Sep 1;119(5):1005-13.
9 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
10 Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
11 Methyl-4-phenylpyridinium ion modulates expression of mitochondrial uncoupling proteins 2, 4, and 5 in catecholaminergic (SK-N-SH) cells. J Neurosci Res. 2005 Jul 15;81(2):261-8.
12 Mitochondrial uncoupling protein-2 (UCP2) mediates leptin protection against MPP+ toxicity in neuronal cells. Neurotox Res. 2010;17(4):332-43.
13 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
14 Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
15 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
16 A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells. Arch Toxicol. 2024;98(9):2919-2935.
17 Repeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression. Toxicol Sci. 2011;123(1):155-69.

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