Modelled DT Structure
Method: multi-sequence alignment based machine learning
Detail: Structure Info
Drug Transporter (DT) Information
| General Information of DT | |||||
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| DT ID | DTD0136 | ||||
| Gene Name | SLC20A1 | ||||
| Protein Name | Sodium-dependent phosphate transporter 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
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| 3D Structure |
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| Synonyms | GLVR-1; GLVR1; Gibbon ape leukemia virus receptor 1; Leukemia virus receptor 1 homolog; PIT1; Phosphate transporter 1; PiT-1; SLC20A1; Solute carrier family 20 member 1 | ||||
| DT Family | Inorganic Phosphate Transporter (PIT) Family ; | ||||
| Tissue Specificity | Ubiquitously expressed. | ||||
| Function | This transporter may play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. | ||||
| Endogenous Substrate(s) | Na+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Sodium-dependent phosphate transporter 1 |
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(β) Cell Distribution Level of Sodium-dependent phosphate transporter 1 |
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(γ) Organelle Distribution Level of Sodium-dependent phosphate transporter 1 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Sodium-dependent phosphate transporter 1 |
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(γ) Transcriptional Regulation of Sodium-dependent phosphate transporter 1 |
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(δ) Epigenetic Regulation of Sodium-dependent phosphate transporter 1 |
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(ε) Exogenous Modulation of Sodium-dependent phosphate transporter 1 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Sodium-dependent phosphate transporter 1 |
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(β) Disease-specific Protein Abundances of Sodium-dependent phosphate transporter 1 |
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(γ) Species- and Tissue-specific DT Abundances |
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| Molecular Transporting Profile of This DT | |||||
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Full List of Drug(s) Transported by This DT |
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Approved Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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Phosphate
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Approved | Drug Info | Constipation | ME05.0 | [1] |
| References | |||||
| 1 | Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. | ||||
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