Drug Transporter (DT) Information

General Information of DT
DT ID DTD0082
Gene Name SLC12A1
Protein Name Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
Gene ID
6557
UniProt ID
Q13621
TCDB ID
2.A.30.1.2
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:6PZT_A

Identity:66.178%

Minimized Score:-1830.241 kcal/mol

Detail: Structure Info

Synonyms BSC1; Kidney-specific Na-K-Cl symporter; NKCC2; SLC12A1; Solute carrier family 12 member 1
DT Family Cation-Chloride Cotransporter (CCC) Family ;
Tissue Specificity Kidney specific.
Function This transporter mediates sodium and chloride reabsorption and plays a vital role in the regulation of ionic balance and cell volume.
Disease(s) Severe mood disorders [ICD-11:6A8Z]
Endogenous Substrate(s) NaCl
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           2 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Potassium chloride
 Approved Drug Info Hypokalemia 5C77 [1]
Sodium chloride
 Approved Drug Info Severe mood disorders 6A8Z [2]
References
1 Rare mutations in renal sodium and potassium transporter genes exhibit impaired transport function. Curr Opin Nephrol Hypertens. 2014 Jan;23(1):1-8.
2 Upregulation of renal sodium transporters in D5 dopamine receptor-deficient mice. Hypertension. 2010 Jun;55(6):1431-7.

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