Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0082 Transporter Info
Gene Name SLC12A1
Transporter Name Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
Gene ID
6557
UniProt ID
Q13621

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        BACH1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC12A1 gene in breast cancer bone metastasis condition [1]

TF Protein Name

 Transcription regulator protein BACH1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of SLC12A1 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2.

TF Superclass3: Helix-turn-helix domains

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        ELF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC12A1 gene in . condition [2]

TF Protein Name

 ETS-related transcription factor Elf-1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 ETS-related transcription factor Elf-1 (ELF1) has been reported to bind to the transcription of SLC12A1 gene in . condition, which leads to a affected expression of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC12A1 gene [3]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Liver; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC12A1 gene, which in turn affects the expression or function of the drug transporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2.
References
1 Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
2 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
3 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-161. (ID:ENSG00000074803)

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