Drug Transporter (DT) Information

General Information of DT
DT ID DTD0045
Gene Name ABCA7
Protein Name ATP-binding cassette sub-family A member 7
Gene ID
10347
UniProt ID
Q8IZY2
TCDB ID
3.A.1.211.10
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:5XJY_A

Identity:52.669%

Minimized Score:-1629.22 kcal/mol

Detail: Structure Info

Synonyms ABCA-SSN; ABCA7; ABCX; AD9; Autoantigen SS-N; Macrophage ABC transporter
DT Family ATP-Binding Cassette (ABC) Superfamily ;
Tissue Specificity Expressed in leukocytes (at protein level).Widely expressed. Highly expressed in myelo-lymphatic tissuesincluding peripheral leukocytes, thymus, spleen and bone marrow.Isoform 2 is more abundant in lymph node, spleen, thymus andtrachea than isoform 1 which is more strongly expressed in brainand bone marrow.
Function This transporter is probable ATP-binding cassette (ABC) transporter that plays a role in lipid homeostasis and macrophage-mediated phagocytosis ang binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells and may also mediate cholesterol efflux.
Endogenous Substrate(s) Phospholipids
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of ATP-binding cassette sub-family A member 7
Tissue Distribution Level (TD)

(β) Cell Distribution Level of ATP-binding cassette sub-family A member 7
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of ATP-binding cassette sub-family A member 7
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of ATP-binding cassette sub-family A member 7
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of ATP-binding cassette sub-family A member 7
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of ATP-binding cassette sub-family A member 7
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of ATP-binding cassette sub-family A member 7
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of ATP-binding cassette sub-family A member 7
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of ATP-binding cassette sub-family A member 7
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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