General Information of Drug Transporter (DT)
DT ID	DTD0045 Transporter Info
Gene Name	ABCA7
Transporter Name	ATP-binding cassette sub-family A member 7
Gene ID	10347
UniProt ID	Q8IZY2
Modelled Structures of This DT
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Detail Information of Structural Model
Method	Homology modeling
Template PDB	5XJY_A		Identity	52.669%
Performance	Minimized Score	-1629.22 kcal/mol
	Ramachandra Favored	Poor
	QMEANBrane Quality	Medium
Ramachandran Plot
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	Ramz Z Score	-2.08 ±0.17
	Residues in Favored Region	1797	Ramachandran favored	92.96%
	Number of Outliers	37	Ramachandran outliers	1.91%
Local Quality
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	QMEANBrane Score		0.7
AlphaFold Protein Structure Database	Q8IZY2 Click to jump to the details page
SWISS-MODEL Database	Q8IZY2 Click to jump to the details page
Experimental Structures of This DT
PDB ID	Scanning Method	Resolution	Expression System	Details	Ref
8EDW	EM	3.6 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A
Sequence Length	2146		Mutation	No
8EE6	EM	4 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A
Sequence Length	2146		Mutation	No
8EEB	EM	3.9 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A
Sequence Length	2146		Mutation	No
8EOP	EM	3.7 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A
Sequence Length	2146		Mutation	Yes
References
1	Cryo-EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms. EMBO J. 2023;42(3):e111065.

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