Detail Information of Mutation-induced Spatial Variation
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0045 Transporter Info | ||||
| Gene Name | ABCA7 | ||||
| Transporter Name | ATP-binding cassette sub-family A member 7 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Mutation-induced Structural Variation (MSV) of This DT | |||||
| PDB ID | |||||
| Expression System | Homo sapiens | ||||
| Method | EM | ||||
| Resolution | 3.7 Å | ||||
| Corresponding chain | A | ||||
| Mutation Site(s) | E965Q; E1951Q | [1] | |||
| Structure Details | |||||
| Modeling Method | EM | ||||
| Publication year | 2022 | ||||
| PDB ID | Scanning Method | Resolution | Mutation Sites | Details | Ref |
| 8EOP | EM | 3.7 Å | E965Q; E1951Q | [1] | |
| Structure | |||||
| Expression System | Homo sapiens | ||||
| Corresponding chain | A | ||||
| Sequence Length | 1-2146 | Mutation | Yes | ||
| References | |||||
| 1 | Cryo-EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms. EMBO J. 2023;42(3):e111065. | ||||
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