Drug Transporter (DT) Information

General Information of DT
DT ID DTD0041
Gene Name ABCA3
Protein Name ATP-binding cassette sub-family A member 3
Gene ID
21
UniProt ID
Q99758
TCDB ID
3.A.1.211.5
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:5XJY_A

Identity:40%

Minimized Score:-1100.865 kcal/mol

Detail: Structure Info

Synonyms ABC-C transporter; ATP-binding cassette transporter 3; ATP-binding cassette 3; ABC3
DT Family ATP-Binding Cassette (ABC) Superfamily
Cholesterol/Phospholipid/Retinal (CPR) Flippase Family (ABCA)
Tissue Specificity Highly expressed in lung, followed by brain,pancreas, skeletal muscle and heart. Weakly expressed in placenta,kidney and liver. Also expressed in medullary thyroid carcinomacells (MTC) and in C-cell carcinoma.
Function This transporter plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol.
Endogenous Substrate(s) lipids, proteins
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of ATP-binding cassette sub-family A member 3
Tissue Distribution Level (TD)

(β) Cell Distribution Level of ATP-binding cassette sub-family A member 3
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of ATP-binding cassette sub-family A member 3
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of ATP-binding cassette sub-family A member 3
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of ATP-binding cassette sub-family A member 3
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of ATP-binding cassette sub-family A member 3
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of ATP-binding cassette sub-family A member 3
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of ATP-binding cassette sub-family A member 3
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of ATP-binding cassette sub-family A member 3
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Mitoxantrone
 Approved Drug Info Metastatic breast cancer 2C6Y [1]
References
1 A distinct "side population" of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14228-33.

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