General Information of Drug Transporter (DT)
DT ID	DTD0041 Transporter Info
Gene Name	ABCA3
Protein Name	ATP-binding cassette sub-family A member 3
Gene ID	21
UniProt ID	Q99758
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs13332514
Site of GPD	chr16:2317335 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A
Minor Allele Frequency	A=0.0873/391 (Global)
Allele T	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
N.A.	N.A.	Respiratory Distress Syndrome	Correlated with the chronic lung disease in very premature infants (compare with allele C)		[ 1]
Genetic Polymorphism	rs150929
Site of GPD	chr16:2278649 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A / G>C / G>T
Minor Allele Frequency	G=0.5190/1027 (Global)
Genotypes GG + GT	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Imatinib	N.A.	Hypertriglyceridemia	Genotypes GG + GT is associated with decreased response to imatinib in people with Leukemia, Myelogenous, Chronic, BCR-ABL Positive as compared to genotype TT.		[ 2]
References
1	Haplotype analysis of ABCA3: association with respiratory distress in very premature infants. Ann Med. 2008;40(1):56-65.
2	Relationship between SLCO1B3 and ABCA3 polymorphisms and imatinib response in chronic myeloid leukemia patients. Hematology. 2015 Apr;20(3):137-42.

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