Drug Transporter (DT) Information

General Information of DT
DT ID DTD0542
Gene Name ANXA2
Protein Name Annexin A2
Gene ID
302
UniProt ID
P07355
TCDB ID
1.A.31.1.4
3D Structure

Crystal Structure

Crystallisation Method:X-ray

PDB ID:6TWX

Corresponding Chain:A/B

Sequence Length:22-339

Detail: Struture Info

Synonyms Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36
DT Family Annexin (Annexin) Family ;
Function This transporter binds two calcium ions with high affinity. Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids.
Endogenous Substrate(s) Annexin a2; Ions
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Annexin A2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Annexin A2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Annexin A2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Annexin A2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Annexin A2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Annexin A2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Annexin A2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Annexin A2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Annexin A2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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