Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0542 Transporter Info
Gene Name	ANXA2
Transporter Name	Annexin A2
Gene ID	302
UniProt ID	P07355

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	ANXA2 mRNA results in decreased susceptibility to Fluorouracil		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	TP53 protein affects the reaction Fluorouracil results in increased expression of ANXA2 mRNA		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Cytarabine results in increased expression of ANXA2 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Testosterone co-treated with Calcitriol results in increased expression of ANXA2 mRNA		[13]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Testosterone co-treated with Calcitriol results in increased expression of ANXA2 mRNA		[13]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Tretinoin affects the localization of and results in decreased expression of ANXA2 protein		[59]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Hydralazine co-treated with Valproic Acid results in increased expression of ANXA2 mRNA		[78]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Valproic Acid affects the expression of ANXA2 mRNA		[89]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	ANXA2 protein results in decreased susceptibility to Arsenic Trioxide		[58]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Arsenic Trioxide affects the localization of and results in decreased expression of ANXA2 protein		[59]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Arsenic Trioxide results in decreased expression of and results in increased degradation of ANXA2 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Arsenic Trioxide results in increased expression of ANXA2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Decitabine co-treated with Vorinostat affects the expression of ANXA2 mRNA		[74]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of ANXA2 5' UTR		[62]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased expression of ANXA2 mRNA		[63]
Regulation Mechanism			Transcription Factor Info
1-Methyl-4-phenylpyridinium	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1-Methyl-4-phenylpyridinium affects the expression of ANXA2 mRNA		[54]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	1-Methyl-4-phenylpyridinium results in increased expression of ANXA2 protein		[40]
Regulation Mechanism			Transcription Factor Info
2,3-bis(3'-hydroxybenzyl)butyrolactone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of ANXA2 mRNA		[55]
Regulation Mechanism			Transcription Factor Info
2,3-dimethoxy-1,4-naphthoquinone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2,3-dimethoxy-1,4-naphthoquinone results in increased expression of ANXA2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	2,3-dimethoxy-1,4-naphthoquinone results in increased expression of ANXA2 protein		[56]
Regulation Mechanism			Transcription Factor Info
2-amino-14,16-dimethyloctadecan-3-ol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-amino-14,16-dimethyloctadecan-3-ol results in decreased expression of ANXA2 protein		[57]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	9 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
artenimol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	artenimol analog binds to ANXA2 protein		[60]
Regulation Mechanism			Transcription Factor Info
Asbestos, Crocidolite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Asbestos, Crocidolite results in increased expression of ANXA2 protein		[61]
Regulation Mechanism			Transcription Factor Info
azoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	azoxystrobin results in decreased expression of ANXA2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
belinostat	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	belinostat results in increased expression of ANXA2 mRNA		[17]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
benzo(e)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene results in increased methylation of ANXA2 intron		[64]
Regulation Mechanism			Transcription Factor Info
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ANXA2 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
beta-lapachone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	beta-lapachone results in increased expression of ANXA2 mRNA		[65]
Regulation Mechanism			Transcription Factor Info
bisphenol A	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in decreased expression of ANXA2 mRNA		[66]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bisphenol A results in decreased expression of ANXA2 protein		[67]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	bisphenol A results in increased expression of ANXA2 mRNA		[68]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	bisphenol A results in increased expression of ANXA2 protein		[69]
Regulation Mechanism			Transcription Factor Info
bisphenol AF	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol AF results in increased expression of ANXA2 protein		[49]
Regulation Mechanism			Transcription Factor Info
bisphenol B	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol B results in increased expression of ANXA2 protein		[49]
Regulation Mechanism			Transcription Factor Info
bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol F results in increased expression of ANXA2 protein		[49]
Regulation Mechanism			Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol S results in increased expression of ANXA2 protein		[49]
Regulation Mechanism			Transcription Factor Info
Bucladesine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate results in decreased expression of ANXA2 mRNA		[70]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased expression of ANXA2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
Carboxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Carboxin results in decreased expression of ANXA2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to ANXA2 gene		[72]
Regulation Mechanism			Transcription Factor Info
chloropicrin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	chloropicrin results in increased expression of ANXA2 mRNA		[41]
Regulation Mechanism			Transcription Factor Info
coumarin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	coumarin results in increased phosphorylation of ANXA2 protein		[71]
Regulation Mechanism			Transcription Factor Info
Coumestrol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of ANXA2 mRNA		[55]
Regulation Mechanism			Transcription Factor Info
cupric oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cupric oxide results in decreased phosphorylation of ANXA2 protein		[73]
Regulation Mechanism			Transcription Factor Info
Decitabine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Decitabine co-treated with Vorinostat affects the expression of ANXA2 mRNA		[74]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	trichostatin A co-treated with Decitabine results in increased expression of ANXA2 protein		[75]
Regulation Mechanism			Transcription Factor Info
dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dicrotophos results in decreased expression of ANXA2 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
Dimethylnitrosamine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dimethylnitrosamine results in increased expression of ANXA2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	9 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
entinostat	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	entinostat results in increased expression of ANXA2 mRNA		[17]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate results in decreased expression of ANXA2 mRNA		[70]
Regulation Mechanism			Transcription Factor Info
Furaldehyde	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	pyrogallol 1,3-dimethyl ether co-treated with Furaldehyde results in increased expression of and affects the localization of ANXA2 protein		[76]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Sodium Chloride co-treated with Furaldehyde results in increased expression of and affects the localization of ANXA2 protein		[76]
Regulation Mechanism			Transcription Factor Info
Gasoline	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with isobutyl alcohol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in decreased expression of ANXA2 mRNA		[77]
Regulation Mechanism			Transcription Factor Info
Hydralazine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Hydralazine co-treated with Valproic Acid results in increased expression of ANXA2 mRNA		[78]
Regulation Mechanism			Transcription Factor Info
isobutyl alcohol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with isobutyl alcohol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in decreased expression of ANXA2 mRNA		[77]
Regulation Mechanism			Transcription Factor Info
K 7174	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	K 7174 results in decreased expression of ANXA2 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
Lactic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Lactic Acid results in increased expression of ANXA2 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
Lasalocid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Lasalocid results in increased expression of ANXA2 protein		[56]
Regulation Mechanism			Transcription Factor Info
Medroxyprogesterone Acetate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate results in decreased expression of ANXA2 mRNA		[70]
Regulation Mechanism			Transcription Factor Info
mercuric bromide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	mercuric bromide results in increased expression of ANXA2 mRNA		[17]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
Methapyrilene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methapyrilene results in increased methylation of ANXA2 intron		[64]
Regulation Mechanism			Transcription Factor Info
methylmercuric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in increased expression of ANXA2 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
nickel chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	nickel chloride results in increased expression of ANXA2 protein		[29]
Regulation Mechanism			Transcription Factor Info
nickel sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	nickel sulfate results in increased expression of ANXA2 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of ANXA2 mRNA		[81]
Regulation Mechanism			Transcription Factor Info
Oleic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Palmitic Acid co-treated with Oleic Acid affects the expression of ANXA2 mRNA		[82]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Palmitic Acid co-treated with Oleic Acid co-treated with TNF protein results in increased expression of ANXA2 mRNA		[82]
Regulation Mechanism			Transcription Factor Info
Ozone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Air Pollutants results in increased abundance of Ozone which affects the expression of ANXA2 mRNA		[83]
Regulation Mechanism			Transcription Factor Info
Palmitic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Palmitic Acid co-treated with Oleic Acid affects the expression of ANXA2 mRNA		[82]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Palmitic Acid co-treated with Oleic Acid co-treated with TNF protein results in increased expression of ANXA2 mRNA		[82]
Regulation Mechanism			Transcription Factor Info
p-Chloromercuribenzoic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	p-Chloromercuribenzoic Acid results in increased expression of ANXA2 mRNA		[17]
Regulation Mechanism			Transcription Factor Info
picoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	picoxystrobin results in decreased expression of ANXA2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
Potassium Dichromate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Potassium Dichromate results in increased expression of ANXA2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
potassium perchlorate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	potassium perchlorate results in decreased expression of ANXA2 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
pyrogallol 1,3-dimethyl ether	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	pyrogallol 1,3-dimethyl ether co-treated with Furaldehyde results in increased expression of and affects the localization of ANXA2 protein		[76]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether results in decreased expression of and affects the localization of ANXA2 protein		[76]
Regulation Mechanism			Transcription Factor Info
quinoline	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	quinoline analog results in increased expression of ANXA2 protein		[84]
Regulation Mechanism			Transcription Factor Info
raltitrexed	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	raltitrexed results in increased expression of ANXA2 mRNA		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	TYMS protein inhibits the reaction raltitrexed results in increased expression of ANXA2 mRNA		[1]
Regulation Mechanism			Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog affects the secretion of ANXA2 protein		[85]
Regulation Mechanism			Transcription Factor Info
sodium bichromate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium bichromate results in decreased expression of ANXA2 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
Sodium Chloride	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium Chloride co-treated with Furaldehyde results in increased expression of and affects the localization of ANXA2 protein		[76]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether results in decreased expression of and affects the localization of ANXA2 protein		[76]
Regulation Mechanism			Transcription Factor Info
tamibarotene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tamibarotene results in decreased expression of ANXA2 mRNA		[3]
Regulation Mechanism			Transcription Factor Info
thifluzamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	thifluzamide results in decreased expression of ANXA2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
titanium dioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	titanium dioxide results in decreased phosphorylation of ANXA2 protein		[86]
Regulation Mechanism			Transcription Factor Info
tributyltinisothiocyanate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tributyltinisothiocyanate results in decreased expression of ANXA2 protein		[46]
Regulation Mechanism			Transcription Factor Info
trichostatin A	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	trichostatin A co-treated with Decitabine results in increased expression of ANXA2 protein		[75]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	trichostatin A results in increased expression of ANXA2 mRNA		[87]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	trichostatin A results in increased expression of ANXA2 protein		[75]
Regulation Mechanism			Transcription Factor Info
triphenyltin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	triphenyltin analog results in decreased expression of ANXA2 protein		[46]
Regulation Mechanism			Transcription Factor Info
tris(2-butoxyethyl) phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tris(2-butoxyethyl) phosphate affects the expression of ANXA2 mRNA		[88]
Regulation Mechanism			Transcription Factor Info
Dietary Constituent
Iron	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Iron deficiency results in increased expression of ANXA2 mRNA		[10]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Fluorouracil	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Fluorouracil increases the expression of ANXA2		[1]
Irinotecan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Irinotecan increases the expression of ANXA2		[1]
Oxaliplatin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Oxaliplatin increases the expression of ANXA2		[1]
Ouabain	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ouabain affects the expression of ANXA2		[4]
Ibuprofen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ibuprofen affects the expression of ANXA2		[5]
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic affects the expression of ANXA2		[6]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate increases the expression of ANXA2		[7]
Rosiglitazone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Rosiglitazone affects the expression of ANXA2		[8]
Thalidomide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thalidomide inhibits the expression of ANXA2		[9]
Vitamin D	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vitamin D affects the expression of ANXA2		[10]
Cytarabine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cytarabine inhibits the expression of ANXA2		[11]
Daunorubicin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Daunorubicin inhibits the expression of ANXA2		[12]
Calcitriol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Calcitriol increases the expression of ANXA2		[13]
Testosterone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Testosterone increases the expression of ANXA2		[13]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of ANXA2		[14]
Vincristine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vincristine increases the expression of ANXA2		[15]
Belinostat	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Belinostat increases the expression of ANXA2		[17]
Panobinostat	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Panobinostat increases the expression of ANXA2		[17]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Urethane inhibits the expression of ANXA2		[18]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid inhibits the expression of ANXA2		[19]
Alitretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Alitretinoin inhibits the expression of ANXA2		[20]
Potassium perchlorate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Potassium perchlorate inhibits the expression of ANXA2		[21]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Doxorubicin increases the expression of ANXA2		[22]
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the expression of ANXA2		[23]
Hydrogen Peroxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide increases the expression of ANXA2		[25]
Tretinoin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of ANXA2		[26]
Valproic Acid	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of ANXA2		[27]
Arsenic Trioxide	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide inhibits the expression of ANXA2		[12]
Vorinostat	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vorinostat increases the expression of ANXA2		[28]
Drug Marketed but not Approved by US FDA
Raltitrexed	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Raltitrexed increases the expression of ANXA2		[1]
Catechin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Catechin increases the expression of ANXA2		[2]
Demecolcine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Demecolcine increases the expression of ANXA2		[15]
Zinc Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zinc Sulfate affects the expression of ANXA2		[16]
Rotenone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Rotenone increases the expression of ANXA2		[24]
Drug in Phase 2/3 Trial
AM-80	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	AM-80 inhibits the expression of ANXA2		[3]
Drug in Phase 3 Trial
Resveratrol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Resveratrol increases the expression of ANXA2		[37]
Drug in Phase 2 Trial
Bisphenol B	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol B increases the expression of ANXA2		[49]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A inhibits the expression of ANXA2		[52]
MS-275	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	MS-275 increases the expression of ANXA2		[28]
Drug in Phase 1 Trial
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Quercetin increases the expression of ANXA2		[30]
Dinitrochlorobenzene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dinitrochlorobenzene increases the expression of ANXA2		[31]
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of ANXA2		[17]
Investigative Drug
Phenylmercuric Acetate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenylmercuric Acetate increases the expression of ANXA2		[17]
Milchsaure	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Milchsaure increases the expression of ANXA2		[44]
Tributyltin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tributyltin inhibits the expression of ANXA2		[46]
MG-132	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	MG-132 inhibits the expression of ANXA2		[47]
N-ethylmaleimide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	N-ethylmaleimide inhibits the activity of ANXA2		[53]
Patented Pharmaceutical Agent
K-7174	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	K-7174 inhibits the expression of ANXA2		[39]
Natural Product
Bromovanin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bromovanin increases the expression of ANXA2		[35]
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Particulate Matter increases the expression of ANXA2		[36]
Vitallium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vitallium inhibits the expression of ANXA2		[38]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of ANXA2		[42]
Gallic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gallic Acid inhibits the expression of ANXA2		[50]
Caffeine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Caffeine results in decreased phosphorylation of ANXA2 protein		[71]
Regulation Mechanism			Transcription Factor Info
Environmental toxicant
DT Modulation1	ANXA2 protein binds to Lead		[79]
Regulation Mechanism			Transcription Factor Info
Bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol F increases the expression of ANXA2		[49]
Acute Toxic Substance
Nickel chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nickel chloride increases the expression of ANXA2		[29]
Mercury	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Mercury increases the expression of ANXA2		[32]
Chloropicrin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Chloropicrin increases the expression of ANXA2		[41]
Antimycin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Antimycin A increases the expression of ANXA2		[24]
Cadmium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium increases the expression of ANXA2		[51]
Carcinogen
Dimethyl nitrosamine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dimethyl nitrosamine increases the expression of ANXA2		[32]
Sodium bichromate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium bichromate inhibits the expression of ANXA2		[33]
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of ANXA2		[48]
Chromium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Chromium results in increased expression of ANXA2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
Nickel	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nickel results in increased expression of ANXA2 mRNA		[80]
Regulation Mechanism			Transcription Factor Info
Fungicide
Azoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Azoxystrobin inhibits the expression of ANXA2		[24]
Pesticide/Insecticide
Dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dicrotophos inhibits the expression of ANXA2		[43]
Health and Environmental Toxicant
Lead	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Lead inhibits the expression of ANXA2		[34]
Nano-sized iron particle	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nano-sized iron particle increases the expression of ANXA2		[10]
1-methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1-methyl-4-phenylpyridinium increases the expression of ANXA2		[40]
Diethylhexyl Phthalate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diethylhexyl Phthalate increases the expression of ANXA2		[45]

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