Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0542 Transporter Info
Gene Name	ANXA2
Transporter Name	Annexin A2
Gene ID	302
UniProt ID	P07355

Post-Translational Modification of This DT
Overview ofANXA2 Modification Sites with Functional and Structural Information
Sequence	M S T V H E I L C K L S L E G D H S T P P S A Y G S V K A Y T N F D A E R D A L N I E T A I K T K G V D E V T I V N I L T N R S N A Q R Q D I A F A Y Q R R T K K E L A S A L K S A L S G H L E T V I L G L L K T P A Q Y D A S E L K A S M K G L G T D E D S L I E I I C S R T N Q E L Q E I N R V Y K E M Y K T D L E K D I I S D T S G D F R K L M V A L A K G R R A E D G S V I D Y E L I D Q D A R D L Y D A G V K R K G T D V P K W I S I M T E R S V P H L Q K V F D R Y K S Y S P Y D M L E S I R K E V K G D L E N A F L N L V Q C I Q N K P L Y F A D R L Y D S M K G K G T R D K V L I R I M V S R S E V D M L K I R S E F K R K Y G K S L Y Y Y I Q Q D T K G D Y Q K A L L Y L C G G D D
PTM type	X-Acetylation X-Glutathionylation X-Malonylation X-Methylation X-O-glycosylation X-Oxidation X-Phosphorylation X-Phosphorylation X-S-glutathionylation X-S-nitrosylation X-S-palmitoylation X-S-sulfhydration X-Succinylation X-Sulfoxidation X-SUMOylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Acetylation
Alanine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[1]
Role of PTM	Potential impacts
Modified Residue	Alanine	Modified Location	175
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Alanine 175 has the potential to affect its expression or activity.
Arginine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[1]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	245
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Arginine 245 has the potential to affect its expression or activity.
Asparticacid	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[1]
Role of PTM	Potential impacts
Modified Residue	Asparticacid	Modified Location	166
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Asparticacid 166 has the potential to affect its expression or activity.
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[1]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	133
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Cystine 133 has the potential to affect its expression or activity.
Glutamicacid	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[1]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	297
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Glutamicacid 297 has the potential to affect its expression or activity.
Glutamine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[1]
Role of PTM	Potential impacts
Modified Residue	Glutamine	Modified Location	320
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Glutamine 320 has the potential to affect its expression or activity.
Glycine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[1]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	122
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Glycine 122 has the potential to affect its expression or activity.
Leucine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[1]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	170
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Leucine 170 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[1]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	331
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Leucine 331 has the potential to affect its expression or activity.
Lysine	22 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	10
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 10 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	28
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 28 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ANXA2			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	47
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 47 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ANXA2			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	49
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 49 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ANXA2			[1], [5]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	104
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 104 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ANXA2			[2], [6]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	115
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 115 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ANXA2			[4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	119
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 119 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ANXA2			[2], [7]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	148
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 148 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ANXA2			[2], [6]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	152
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 152 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ANXA2			[2], [4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	157
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 157 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ANXA2			[4], [8]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	176
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 176 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ANXA2			[2], [4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	204
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 204 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence ANXA2			[2], [4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	212
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 212 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence ANXA2			[2], [7]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	227
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 227 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence ANXA2			[2], [6]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	233
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 233 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence ANXA2			[4], [9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	266
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 266 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence ANXA2			[2], [6]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	279
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 279 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence ANXA2			[2], [7]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	302
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 302 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence ANXA2			[10]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	310
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 310 has the potential to affect its expression or activity.
PTM Phenomenon20	Have the potential to influence ANXA2			[2], [6]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	313
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 313 has the potential to affect its expression or activity.
PTM Phenomenon21	Have the potential to influence ANXA2			[2], [6]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	324
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 324 has the potential to affect its expression or activity.
PTM Phenomenon22	Have the potential to influence ANXA2			[2], [4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	329
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ANXA2 Lysine 329 has the potential to affect its expression or activity.
Glutathionylation
Cystine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[11], [12]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	9
Experimental Method	Co-Immunoprecipitation
Detailed Description	Glutathionylation at ANXA2 Cystine 9 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[11], [13]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	133
Experimental Method	Co-Immunoprecipitation
Detailed Description	Glutathionylation at ANXA2 Cystine 133 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ANXA2			[12]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	262
Experimental Method	Co-Immunoprecipitation
Detailed Description	Glutathionylation at ANXA2 Cystine 262 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ANXA2			[12]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	335
Experimental Method	Co-Immunoprecipitation
Detailed Description	Glutathionylation at ANXA2 Cystine 335 has the potential to affect its expression or activity.
Malonylation
Lysine	11 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	80
Experimental Method	Co-Immunoprecipitation
Detailed Description	Malonylation at ANXA2 Lysine 80 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	81
Experimental Method	Co-Immunoprecipitation
Detailed Description	Malonylation at ANXA2 Lysine 81 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ANXA2			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	119
Experimental Method	Co-Immunoprecipitation
Detailed Description	Malonylation at ANXA2 Lysine 119 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ANXA2			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	148
Experimental Method	Co-Immunoprecipitation
Detailed Description	Malonylation at ANXA2 Lysine 148 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ANXA2			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	152
Experimental Method	Co-Immunoprecipitation
Detailed Description	Malonylation at ANXA2 Lysine 152 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ANXA2			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	169
Experimental Method	Co-Immunoprecipitation
Detailed Description	Malonylation at ANXA2 Lysine 169 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ANXA2			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	176
Experimental Method	Co-Immunoprecipitation
Detailed Description	Malonylation at ANXA2 Lysine 176 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ANXA2			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	233
Experimental Method	Co-Immunoprecipitation
Detailed Description	Malonylation at ANXA2 Lysine 233 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ANXA2			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	279
Experimental Method	Co-Immunoprecipitation
Detailed Description	Malonylation at ANXA2 Lysine 279 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ANXA2			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	310
Experimental Method	Co-Immunoprecipitation
Detailed Description	Malonylation at ANXA2 Lysine 310 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ANXA2			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	313
Experimental Method	Co-Immunoprecipitation
Detailed Description	Malonylation at ANXA2 Lysine 313 has the potential to affect its expression or activity.
Methylation
Lysine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	227
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at ANXA2 Lysine 227 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	313
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at ANXA2 Lysine 313 has the potential to affect its expression or activity.
O-glycosylation
Serine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2
Experimental Method	Co-Immunoprecipitation
Detailed Description	O-linked Glycosylation at ANXA2 Serine 2 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	153
Experimental Method	Co-Immunoprecipitation
Detailed Description	O-linked Glycosylation at ANXA2 Threonine 153 has the potential to affect its expression or activity.
Oxidation
Cysteine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[17]
Role of PTM	Potential impacts
Modified Residue	Cysteine	Modified Location	208
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ANXA2 Cysteine 208 has the potential to affect its expression or activity.
Cystine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[17], [18]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	133
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ANXA2 Cystine 133 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[17]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	262
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ANXA2 Cystine 262 has the potential to affect its expression or activity.
Phosphorylation
Arginine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[19], [20]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	37
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Arginine 37 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[20]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	145
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Arginine 145 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ANXA2			[20]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	179
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Arginine 179 has the potential to affect its expression or activity.
Asparticacid	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[21]
Role of PTM	Potential impacts
Modified Residue	Asparticacid	Modified Location	16
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Asparticacid 16 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[20]
Role of PTM	Potential impacts
Modified Residue	Asparticacid	Modified Location	110
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Asparticacid 110 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ANXA2			[20]
Role of PTM	Potential impacts
Modified Residue	Asparticacid	Modified Location	182
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Asparticacid 182 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ANXA2			[20]
Role of PTM	Potential impacts
Modified Residue	Asparticacid	Modified Location	239
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Asparticacid 239 has the potential to affect its expression or activity.
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[19]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	335
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Cystine 335 has the potential to affect its expression or activity.
Glutamicacid	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[19]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	36
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Glutamicacid 36 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[20]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	130
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Glutamicacid 130 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ANXA2			[22]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	253
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Glutamicacid 253 has the potential to affect its expression or activity.
Glycine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[20]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	202
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Glycine 202 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[19], [20]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	336
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Glycine 336 has the potential to affect its expression or activity.
Isoleucine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[19], [20]
Role of PTM	Potential impacts
Modified Residue	Isoleucine	Modified Location	42
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Isoleucine 42 has the potential to affect its expression or activity.
Leucine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[19], [20]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	40
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Leucine 40 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[20]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	103
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Leucine 103 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ANXA2			[20]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	252
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Leucine 252 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ANXA2			[20]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	332
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Leucine 332 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ANXA2			[19], [20]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	334
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Leucine 334 has the potential to affect its expression or activity.
Lysine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[20]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	49
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Lysine 49 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[19], [22]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	206
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Lysine 206 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ANXA2			[20]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	233
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Lysine 233 has the potential to affect its expression or activity.
Phenylalanine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[19], [20]
Role of PTM	Potential impacts
Modified Residue	Phenylalanine	Modified Location	256
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Phenylalanine 256 has the potential to affect its expression or activity.
Serine	26 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Stabilises a protein conformation			[23]
Role of PTM	Protein Stability
Affected Drug/Substrate	Calcium-dependent lipid	Results for Drug	Affecting the inward transport of calcium-dependent lipid
Modified Residue	Serine	Modified Location	25
Modified State	Serine to Glutamicacid mutation
Related Enzyme	Tyrosine-protein kinase CSK (CSK)
Experimental Method	Co-Immunoprecipitation
Detailed Description	Removal of the Phosphorylation at ANXA2 Serine 25 (i.e. Serine to Glutamicacid mutation) have been reported to stabilize its protein conformation .
PTM Phenomenon2	No significant effect			[23]
Role of PTM	No Significant Effect
Affected Drug/Substrate	Calcium-dependent lipid	Results for Drug	Affecting the inward transport of calcium-dependent lipid
Modified Residue	Serine	Modified Location	11
Modified State	Serine to Asparticacid/Glutamicacid mutation
Related Enzyme	Tyrosine-protein kinase CSK (CSK)
Experimental Method	Co-Immunoprecipitation
Detailed Description	Removal of the Phosphorylation at ANXA2 Serine 11 (i.e. Serine to Asparticacid/Glutamicacid mutation) have been reported to have no significant alteration in its expression or activity.
PTM Phenomenon3	Have the potential to influence ANXA2			[24]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 2 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ANXA2			[24], [25]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	12
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 12 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ANXA2			[24], [26]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	18
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 18 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ANXA2			[24], [27]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	22
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 22 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ANXA2			[24]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	26
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 26 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ANXA2			[28], [29]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	85
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 85 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ANXA2			[30], [31]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	89
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 89 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ANXA2			[30]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	92
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 92 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ANXA2			[32]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	112
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 112 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ANXA2			[33]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	117
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 117 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence ANXA2			[26], [34]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	127
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 127 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence ANXA2			[35]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	134
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 134 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence ANXA2			[28]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	161
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 161 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence ANXA2			[28], [34]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	164
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 164 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence ANXA2			[26], [34]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	184
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 184 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence ANXA2			[30], [36]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	215
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 215 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence ANXA2			[28]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	221
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 221 has the potential to affect its expression or activity.
PTM Phenomenon20	Have the potential to influence ANXA2			[37]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	234
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 234 has the potential to affect its expression or activity.
PTM Phenomenon21	Have the potential to influence ANXA2			[30], [38]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	236
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 236 has the potential to affect its expression or activity.
PTM Phenomenon22	Have the potential to influence ANXA2			[39]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	243
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 243 has the potential to affect its expression or activity.
PTM Phenomenon23	Have the potential to influence ANXA2			[21]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	277
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 277 has the potential to affect its expression or activity.
PTM Phenomenon24	Have the potential to influence ANXA2			[40]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	296
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 296 has the potential to affect its expression or activity.
PTM Phenomenon25	Have the potential to influence ANXA2			[41]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	305
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 305 has the potential to affect its expression or activity.
PTM Phenomenon26	Have the potential to influence ANXA2			[37], [42]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	314
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Serine 314 has the potential to affect its expression or activity.
Threonine	16 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[24], [26]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	3
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Threonine 3 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[24], [43]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	19
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Threonine 19 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ANXA2			[44], [45]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	31
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Threonine 31 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ANXA2			[19]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	44
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Threonine 44 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ANXA2			[19], [20]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	48
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Threonine 48 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ANXA2			[46]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	55
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Threonine 55 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ANXA2			[20]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	61
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Threonine 61 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ANXA2			[20]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	79
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Threonine 79 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ANXA2			[30]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	97
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Threonine 97 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ANXA2			[47]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	105
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Threonine 105 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ANXA2			[34], [48]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	123
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Threonine 123 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ANXA2			[49]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	136
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Threonine 136 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence ANXA2			[32], [50]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	153
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Threonine 153 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence ANXA2			[28]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	163
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Threonine 163 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence ANXA2			[30]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	218
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Threonine 218 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence ANXA2			[51]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	323
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Threonine 323 has the potential to affect its expression or activity.
Tyrosine	20 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Rearrangement of dynamic actin structures			[52]
Role of PTM	Protein Stability
Affected Drug/Substrate	Calcium-dependent lipid	Results for Drug	Affecting the inward transport of calcium-dependent lipid
Modified Residue	Tyrosine	Modified Location	23
Modified State	Tyrosine to Glutamicacid mutation
Related Enzyme	Tyrosine-protein kinase CSK (CSK)
Studied Phenotype	Breast cancer [ICD11: 2C60-2C6Z]
Experimental Method	Co-Immunoprecipitation
Detailed Description	Removal of the Phosphorylation at ANXA2 Tyrosine 23 (i.e. Tyrosine to Glutamicacid mutation) have been reported to enable the rearrangement of its dynamic actin structures.
PTM Phenomenon2	Affecting the surface membrane expression of ANXA2			[53], [54]
Role of PTM	Surface Expression Modulation
Modified Residue	Tyrosine	Modified Location	24
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine 24 have been reported to affect its surface membrane expression.
PTM Phenomenon3	Have the potential to influence ANXA2			[55]
Role of PTM	Potential impacts
Modified Residue	Tyrosine
Studied Phenotype	Hepatocellular carcinoma [ICD11: 2C12.02]
Experimental Material(s)	Chinese hamster ovary (CHO) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ANXA2			[56], [57]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	30
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine 30 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ANXA2			[58], [59]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	75
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine 75 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ANXA2			[58], [60]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	109
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine 109 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ANXA2			[49], [61]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	147
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine 147 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ANXA2			[49], [61]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	151
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine 151 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ANXA2			[56], [62]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	188
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine 188 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ANXA2			[29], [63]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	199
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine 199 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ANXA2			[64], [65]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	232
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine 232 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ANXA2			[58], [66]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	235
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine 235 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence ANXA2			[27], [56]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	238
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine 238 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence ANXA2			[67]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	269
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine 269 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence ANXA2			[21], [68]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	275
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine 275 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence ANXA2			[30], [37]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	316
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine 316 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence ANXA2			[57], [63]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	317
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine 317 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence ANXA2			[57], [69]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	318
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine 318 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence ANXA2			[58]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	327
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine 327 has the potential to affect its expression or activity.
PTM Phenomenon20	Have the potential to influence ANXA2			[40], [58]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	333
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 Tyrosine 333 has the potential to affect its expression or activity.
Unclear Residue	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[55]
Role of PTM	Influencing the Disease Progression
Experimental Method	Co-Immunoprecipitation
Detailed Description	Reduced phosphorylation of ANXA2 has been reported as a mechanism for ethanol's inhibitory effect on hepatocellular carcinoma cell proliferation.
PTM Phenomenon2	Have the potential to influence ANXA2			[20]
Role of PTM	Potential impacts
Modified Location	351
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ANXA2 351 has the potential to affect its expression or activity.
S-glutathionylation
Cystine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[70]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	9
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-glutathionylation (-SSG) at ANXA2 Cystine 9 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[70]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	133
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-glutathionylation (-SSG) at ANXA2 Cystine 133 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ANXA2			[70]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	262
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-glutathionylation (-SSG) at ANXA2 Cystine 262 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ANXA2			[70]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	335
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-glutathionylation (-SSG) at ANXA2 Cystine 335 has the potential to affect its expression or activity.
S-nitrosylation
Cystine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[71]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	9
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-nitrosylation (-SNO) at ANXA2 Cystine 9 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[72], [73]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	133
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-nitrosylation at ANXA2 Cystine 133 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ANXA2			[73]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	262
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-nitrosylation at ANXA2 Cystine 262 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ANXA2			[74]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	335
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-nitrosylation (-SNO) at ANXA2 Cystine 335 has the potential to affect its expression or activity.
S-palmitoylation
Cystine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[75]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	9
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-palmitoylation at ANXA2 Cystine 9 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[75], [76]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	133
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-palmitoylation at ANXA2 Cystine 133 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ANXA2			[75]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	335
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-palmitoylation at ANXA2 Cystine 335 has the potential to affect its expression or activity.
S-sulfhydration
Cystine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[77]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	9
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-sulfhydration (-SSH) at ANXA2 Cystine 9 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[78]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	133
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-sulfhydration (-SSH) at ANXA2 Cystine 133 has the potential to affect its expression or activity.
Succinylation
Lysine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[5]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	119
Experimental Method	Co-Immunoprecipitation
Detailed Description	Succinylation at ANXA2 Lysine 119 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[5]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	176
Experimental Method	Co-Immunoprecipitation
Detailed Description	Succinylation at ANXA2 Lysine 176 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ANXA2			[5]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	227
Experimental Method	Co-Immunoprecipitation
Detailed Description	Succinylation at ANXA2 Lysine 227 has the potential to affect its expression or activity.
Sulfoxidation
Methionine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[79]
Role of PTM	Potential impacts
Modified Residue	Methionine	Modified Location	118
Experimental Method	Co-Immunoprecipitation
Detailed Description	Sulfoxidation at ANXA2 Methionine 118 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[80], [81]
Role of PTM	Potential impacts
Modified Residue	Methionine	Modified Location	171
Experimental Method	Co-Immunoprecipitation
Detailed Description	Sulfoxidation at ANXA2 Methionine 171 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ANXA2			[80]
Role of PTM	Potential impacts
Modified Residue	Methionine	Modified Location	217
Experimental Method	Co-Immunoprecipitation
Detailed Description	Sulfoxidation at ANXA2 Methionine 217 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ANXA2			[80]
Role of PTM	Potential impacts
Modified Residue	Methionine	Modified Location	240
Experimental Method	Co-Immunoprecipitation
Detailed Description	Sulfoxidation at ANXA2 Methionine 240 has the potential to affect its expression or activity.
SUMOylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[82]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	49
Experimental Method	Co-Immunoprecipitation
Detailed Description	Sumoylation at ANXA2 Lysine 49 has the potential to affect its expression or activity.
Ubiquitination
Alanine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[1]
Role of PTM	Potential impacts
Modified Residue	Alanine	Modified Location	175
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Alanine 175 has the potential to affect its expression or activity.
Arginine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[1], [83]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	245
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Arginine 245 has the potential to affect its expression or activity.
Asparticacid	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[1], [83]
Role of PTM	Potential impacts
Modified Residue	Asparticacid	Modified Location	166
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Asparticacid 166 has the potential to affect its expression or activity.
Glutamine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[1]
Role of PTM	Potential impacts
Modified Residue	Glutamine	Modified Location	320
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Glutamine 320 has the potential to affect its expression or activity.
Glycine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[1]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	122
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Glycine 122 has the potential to affect its expression or activity.
Leucine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[1]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	170
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Leucine 170 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[1], [83]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	331
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Leucine 331 has the potential to affect its expression or activity.
Lysine	17 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ANXA2			[84], [85]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	28
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Lysine 28 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ANXA2			[84]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	47
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Lysine 47 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ANXA2			[84]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	49
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Lysine 49 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[86]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	88
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Lysine 88 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ANXA2			[84], [85]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	104
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Lysine 104 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ANXA2			[1], [84]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	115
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Lysine 115 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ANXA2			[83]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	148
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Lysine 148 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ANXA2			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	152
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Lysine 152 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ANXA2			[1], [84]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	157
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Lysine 157 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ANXA2			[84]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	204
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Lysine 204 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ANXA2			[84], [85]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	212
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Lysine 212 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ANXA2			[83]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	227
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Lysine 227 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence ANXA2			[84], [85]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	266
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Lysine 266 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence ANXA2			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	279
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Lysine 279 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence ANXA2			[1], [84]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	302
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Lysine 302 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence ANXA2			[83]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	313
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Lysine 313 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence ANXA2			[87]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	324
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 Lysine 324 has the potential to affect its expression or activity.
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[88]
Role of PTM	Degradation via Proteosome
Experimental Material(s)	tumor tissue
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ANXA2 has been reported to enhance its degradation, contributing to increased aggressiveness in bladder urothelial carcinoma.

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