Drug Transporter (DT) Information

General Information of DT
DT ID DTD0468
Gene Name SLC7A2
Protein Name Cationic amino acid transporter 2
Gene ID
6542
UniProt ID
P52569
TCDB ID
2.A.3.3.8
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:6F34_A

Identity:37.587%

Minimized Score:-1066.647 kcal/mol

Detail: Structure Info

Synonyms ATRC2; CAT-2; CAT2; HCAT2; Low affinity cationic amino acid transporter 2; SLC7A2; Solute carrier family 7 member 2
DT Family Amino Acid-Polyamine-Organocation (APC) Family
Cationic Amino Acid Transporter (CAT) Family
Tissue Specificity Expressed at high levels in the skeletalmuscle, placenta and ovary. Expressed at intermediate levels inthe liver and pancreas and at low levels in the kidney and heart.
Function This transporter functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine).
Endogenous Substrate(s) Arginine; Lysine; Ornithine
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Cationic amino acid transporter 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Cationic amino acid transporter 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Cationic amino acid transporter 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Cationic amino acid transporter 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Cationic amino acid transporter 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Cationic amino acid transporter 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Cationic amino acid transporter 2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Cationic amino acid transporter 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Cationic amino acid transporter 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
L-ornithine
 Preclinical Drug Info Immunomodulatory and wound-healing EL8Y [1]

Endogenous Metabolites (EMs) Handled by This DT

 Endogenous Metabolites (EMs)

 Click to Show/Hide the Full List of EMs:           1 EMs in Total
EM Name PubChem CID Detail Experimental Material Ref
Arginine
6322
EM Info Identified using Slc7a2 knockout mice [2]
References
1 Genetic basis for plasma amino acid concentrations based on absolute quantification: a genome-wide association study in the Japanese population. Eur J Hum Genet. 2019 Apr;27(4):621-630.
2 Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation. Eur J Immunol. 2006 Jun;36(6):1516-26.

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