Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0468 Transporter Info
Gene Name SLC7A2
Transporter Name Cationic amino acid transporter 2
Gene ID
6542
UniProt ID
P52569

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC7A2 gene [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Tissue

 Bone marrow; Colon; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC7A2 gene, which in turn affects the expression or function of the drug transporter Cationic amino acid transporter 2.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC7A2 gene [1]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC7A2 gene, which in turn affects the expression or function of the drug transporter Cationic amino acid transporter 2.

        JUN 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC7A2 gene in coronary artery disease condition [2]

TF Protein Name

 Transcription factor Jun Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor Jun (JUN) has been reported to bind to the transcription of SLC7A2 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Cationic amino acid transporter 2.

        JUNB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC7A2 gene [1]

TF Protein Name

 Transcription factor JunB Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor JunB (JUNB) can directly bind to the SLC7A2 gene, which in turn affects the expression or function of the drug transporter Cationic amino acid transporter 2.

        JUND 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC7A2 gene in coronary artery disease condition [2]

TF Protein Name

 Transcription factor JunD Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor JunD (JUND) has been reported to bind to the transcription of SLC7A2 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Cationic amino acid transporter 2.

       Transcriptional Phenomenon2

 Direct binding to SLC7A2 gene [3]

TF Protein Name

 Transcription factor JunD Transcription Factor Info

Tissue

 Bone marrow; Breast; Cervix; Colon; Coronary artery; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor JunD (JUND) can directly bind to the SLC7A2 gene, which in turn affects the expression or function of the drug transporter Cationic amino acid transporter 2.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        MITF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC7A2 gene in melanoma condition [4]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC7A2 gene in melanoma condition, which leads to an increased expression of the drug transporter Cationic amino acid transporter 2.

        TCF21 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC7A2 gene in Coronary artery disease condition [2]

TF Protein Name

 Transcription factor 21 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 21 (TCF21) has been reported to bind to the SLC7A2 gene in Coronary artery disease condition, which affects the expression or function of the drug transporter Cationic amino acid transporter 2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        ESR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC7A2 gene in breast cancer condition [5]

TF Protein Name

 Estrogen receptor Transcription Factor Info

Studied Phenotype

 Breast cancer [ICD11: 2C60-2C6Z]

Tissue

 Breast

Related DT Changes

 Up regulating

Experimental Material

 Human invasive breast carcinoma of no special type cells (MCF-7)

Detailed Description

 Estrogen receptor (ESR1) has been reported to activate the transcription of SLC7A2 gene in breast cancer condition, which leads to an increased expression of the drug transporter Cationic amino acid transporter 2.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC7A2 gene [6]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Erythroid transcription factor (GATA1) can directly bind to the SLC7A2 gene, which in turn affects the expression or function of the drug transporter Cationic amino acid transporter 2.

        GATA3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC7A2 gene in breast cancer condition [7]

TF Protein Name

 Trans-acting T-cell-specific transcription factor GATA-3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) has been reported to bind to the transcription of SLC7A2 gene in breast cancer condition, which leads to an affected expression of the drug transporter Cationic amino acid transporter 2.

        GATA4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC7A2 gene in gastric cancer condition [8]

TF Protein Name

 Transcription factor GATA-4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of SLC7A2 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Cationic amino acid transporter 2.

        GATA6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC7A2 gene in gastric cancer condition [8]

TF Protein Name

 Transcription factor GATA-6 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor GATA-6 (GATA6) has been reported to activate the transcription of SLC7A2 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Cationic amino acid transporter 2.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC7A2 gene [6]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC7A2 gene, which in turn affects the expression or function of the drug transporter Cationic amino acid transporter 2.

        SALL4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC7A2 gene in health condition [9]

TF Protein Name

 Sal-like protein 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Sal-like protein 4 (SALL4) has been reported to bind to the transcription of SLC7A2 gene in health condition, which leads to an affected expression of the drug transporter Cationic amino acid transporter 2.

        ZNF217 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC7A2 gene in breast cancer condition [10]

TF Protein Name

 Zinc finger protein 217 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of SLC7A2 gene in breast cancer condition, which leads to an affected expression of the drug transporter Cationic amino acid transporter 2.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC7A2 gene in prostate carcinoma condition [11]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC7A2 gene in prostate carcinoma condition, which leads to an affected expression of the drug transporter Cationic amino acid transporter 2.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC7A2 gene [3]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC7A2 gene, which in turn affects the expression or function of the drug transporter Cationic amino acid transporter 2.

        FOXM1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC7A2 gene [12]

TF Protein Name

 Forkhead box protein M1 Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Forkhead box protein M1 (FOXM1) can directly bind to the SLC7A2 gene, which in turn affects the expression or function of the drug transporter Cationic amino acid transporter 2.

      Class3.7: ARID domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        ARID3A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC7A2 gene [3]

TF Protein Name

 AT-rich interactive domain-containing protein 3A Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the SLC7A2 gene, which in turn affects the expression or function of the drug transporter Cationic amino acid transporter 2.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.1: High-mobility group domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SOX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC7A2 gene in colorectal cancer condition [13]

TF Protein Name

 Transcription factor SOX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of SLC7A2 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Cationic amino acid transporter 2.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RELA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC7A2 gene in fibrosarcoma condition [14]

TF Protein Name

 Transcription factor p65 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor p65 (RELA) has been reported to activate the transcription of SLC7A2 gene in fibrosarcoma condition, which leads to an increased expression of the drug transporter Cationic amino acid transporter 2.

      Class6.2: STAT domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        STAT6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC7A2 gene in hypersensitivity pneumonitis condition [15]

TF Protein Name

 Signal transducer and activator of transcription 6 Transcription Factor Info

Studied Phenotype

 Hypersensitivity pneumonitis [ICD11: CA70]

Tissue

 Lung

Related DT Changes

 Up regulating

Experimental Material

 FVB/N mice

Detailed Description

 Signal transducer and activator of transcription 6 (STAT6) has been reported to activate the transcription of SLC7A2 gene in hypersensitivity pneumonitis condition, which leads to an increased expression of the drug transporter Cationic amino acid transporter 2.

      Class6.7: Grainyhead domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GRHL2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC7A2 gene [12]

TF Protein Name

 Grainyhead-like protein 2 homolog Transcription Factor Info

Tissue

 Breast; Bronchus; Ovary; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC7A2 gene, which in turn affects the expression or function of the drug transporter Cationic amino acid transporter 2.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-128. (ID: ENSG00000003989)
2 Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
4 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
5 Identification of novel genes that co-cluster with estrogen receptor alpha in breast tumor biopsy specimens, using a large-scale real-time reverse transcription-PCR approach. Endocr Relat Cancer. 2006 Dec;13(4):1109-20.
6 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
7 Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC Cancer. 2014;14:278.
8 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
9 SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013;53(5):1037-49.
10 Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics. 2014;15(1):520.
11 SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin. Nucleic Acids Res. 2015;43(2):848-61.
12 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
13 ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS. 2010;14(4):369-84.
14 Modulation of gene expression regulated by the transcription factor NF-B/RelA. J Biol Chem. 2014;289(17):11927-11944.
15 The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis. Respir Res. 2010 Jun 24;11(1):87.

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