Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0468 Transporter Info
Gene Name	SLC7A2
Transporter Name	Cationic amino acid transporter 2
Gene ID	6542
UniProt ID	P52569

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Estradiol results in increased expression of SLC7A2 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Progesterone co-treated with Estradiol results in increased expression of SLC7A2 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Testosterone co-treated with Calcitriol results in decreased expression of SLC7A2 mRNA		[5]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Testosterone co-treated with Calcitriol results in decreased expression of SLC7A2 mRNA		[5]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Tretinoin results in increased expression of SLC7A2 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Cyclosporine affects the expression of SLC7A2 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Valproic Acid results in decreased methylation of SLC7A2 gene		[46]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
3-iodothyronamine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC7A2 mRNA affects the uptake of 3-iodothyronamine		[23]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
Acrolein	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of and results in increased oxidation of SLC7A2 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of and results in increased oxidation of SLC7A2 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
alpha-pinene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of and results in increased oxidation of SLC7A2 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of and results in increased oxidation of SLC7A2 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of SLC7A2 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
Asbestos, Crocidolite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Asbestos, Crocidolite affects the expression of SLC7A2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
Asbestos, Serpentine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Asbestos, Serpentine affects the expression of SLC7A2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC7A2 5' UTR		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased methylation of SLC7A2 promoter		[29]
Regulation Mechanism			Transcription Factor Info
bisphenol A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A analog results in increased expression of SLC7A2 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bisphenol A results in increased expression of SLC7A2 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
bisphenol B	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol B results in increased expression of SLC7A2 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
bisphenol Z	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol Z results in increased expression of SLC7A2 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC7A2 gene		[30]
Regulation Mechanism			Transcription Factor Info
Copper	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in decreased expression of SLC7A2 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
cupric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cupric chloride results in increased expression of SLC7A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
diallyl trisulfide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	diallyl trisulfide results in increased expression of SLC7A2 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
K 7174	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	K 7174 results in increased expression of SLC7A2 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
Manganese	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC7A2 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC7A2 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
mercuric bromide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	mercuric bromide results in increased expression of SLC7A2 mRNA		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
methacrylaldehyde	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of and results in increased oxidation of SLC7A2 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of and results in increased oxidation of SLC7A2 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
methylmercuric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in decreased expression of SLC7A2 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
nickel chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	nickel chloride results in increased expression of SLC7A2 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
NSC 689534	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in decreased expression of SLC7A2 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of SLC7A2 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
Ozone	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of and results in increased oxidation of SLC7A2 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of and results in increased oxidation of SLC7A2 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Volatile Organic Compounds co-treated with Ozone results in decreased expression of and results in increased oxidation of SLC7A2 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
picene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	picene results in decreased expression of SLC7A2 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
Progesterone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Progesterone co-treated with Estradiol results in increased expression of SLC7A2 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
S-(1,2-dichlorovinyl)cysteine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	S-(1,2-dichlorovinyl)cysteine inhibits the reaction Lipopolysaccharides results in increased expression of SLC7A2 mRNA		[41]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC7A2 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased expression of SLC7A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
trichostatin A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC7A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	trichostatin A results in increased expression of SLC7A2 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
tri-o-cresyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tri-o-cresyl phosphate results in increased expression of SLC7A2 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
Carcinogen
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC7A2 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
Nanoparticle
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in increased expression of SLC7A2 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
Biotoxin
T-2 Toxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	T-2 Toxin results in decreased expression of SLC7A2 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Medroxyprogesterone Acetate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Medroxyprogesterone Acetate increases the expression of SLC7A2		[1]
Estradiol	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the expression of SLC7A2		[2]
Cytarabine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cytarabine inhibits the expression of SLC7A2		[3]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen affects the expression of SLC7A2		[4]
Calcitriol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Calcitriol inhibits the expression of SLC7A2		[5]
Testosterone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Testosterone inhibits the expression of SLC7A2		[5]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zidovudine inhibits the expression of SLC7A2		[6]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid inhibits the expression of SLC7A2		[7]
Cisplatin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cisplatin inhibits the expression of SLC7A2		[8]
Leflunomide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Leflunomide increases the expression of SLC7A2		[9]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sunitinib increases the expression of SLC7A2		[10]
Tretinoin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of SLC7A2		[11]
Cyclosporine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine increases the expression of SLC7A2		[12]
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of SLC7A2		[13]
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of SLC7A2		[21]
Bisphenol B	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol B increases the expression of SLC7A2		[21]
Drug in Phase 1 Trial
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of SLC7A2		[19]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of SLC7A2		[16]
Investigative Drug
Phenylmercuric Acetate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenylmercuric Acetate increases the expression of SLC7A2		[19]
Patented Pharmaceutical Agent
K-7174	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	K-7174 increases the expression of SLC7A2		[18]
Natural Product
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Particulate Matter inhibits the expression of SLC7A2		[17]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution affects the expression of SLC7A2		[22]
Mycotoxins
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the expression of SLC7A2		[20]
DT Modulation2	Aflatoxin B1 results in decreased methylation of SLC7A2 gene		[20]
Regulation Mechanism			Transcription Factor Info
Zearalenone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zearalenone results in increased expression of SLC7A2 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
Acute Toxic Substance
Nickel chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nickel chloride increases the expression of SLC7A2		[14]
Mercury	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Mercury inhibits the expression of SLC7A2		[15]

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