Drug Transporter (DT) Information

General Information of DT
DT ID DTD0425
Gene Name SLC5A5
Protein Name Sodium/iodide cotransporter
Gene ID
6528
UniProt ID
Q92911
TCDB ID
2.A.21.5.1
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms NIS; Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; SLC5A5; Sodium-iodide symporter; Solute carrier family 5 member 5; TDH1
DT Family Solute:Sodium Symporter (SSS) Family ;
Tissue Specificity Expression is primarily in thyroid tissue, butalso to a lower extent in mammary gland and ovary. Expression isreduced in tumors.
Function This transporter mediates iodide uptake in the thyroid gland.
Endogenous Substrate(s) Br-; Bromate; Chlorate; Periodate; Selenium cyanide; Sodium iodide; Tetrafluoroborate; Thiocyanate
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium/iodide cotransporter
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium/iodide cotransporter
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium/iodide cotransporter
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium/iodide cotransporter
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium/iodide cotransporter
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium/iodide cotransporter
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium/iodide cotransporter
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium/iodide cotransporter
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium/iodide cotransporter
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Nitrate
 Phase 4 Drug Info Stable angina BA40.1 [1]
References
1 The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.21.5.1)

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