Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0425 Transporter Info
Gene Name	SLC5A5
Transporter Name	Sodium/iodide cotransporter
Gene ID	6528
UniProt ID	Q92911

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Troglitazone co-treated with Tretinoin results in increased expression of SLC5A5 mRNA		[3]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Azacitidine co-treated with Butyrates affects the expression of SLC5A5 mRNA		[13]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Butyrates co-treated with Decitabine results in increased expression of SLC5A5 mRNA		[4]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Butyrates co-treated with Decitabine results in increased expression of SLC5A5 mRNA which results in increased uptake of Iodine		[4]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Decitabine co-treated with Tretinoin results in increased expression of SLC5A5 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	1-Methyl-3-isobutylxanthine promotes the reaction Tretinoin co-treated with Hydrocortisone affects the localization of SLC5A5 protein		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	1-Methyl-3-isobutylxanthine promotes the reaction Tretinoin co-treated with Hydrocortisone results in increased expression of SLC5A5 protein		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction Carbamazepine promotes the reaction Tretinoin results in increased expression of SLC5A5 protein		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Carbamazepine promotes the reaction Tretinoin results in increased expression of SLC5A5 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Carbamazepine promotes the reaction Tretinoin results in increased expression of SLC5A5 protein		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Colforsin inhibits the reaction Tretinoin co-treated with Hydrocortisone results in increased activity of SLC5A5 protein		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	Decitabine co-treated with Tretinoin results in increased expression of SLC5A5 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	Dexamethasone co-treated with Tretinoin results in increased expression of SLC5A5 mRNA		[3]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	Dexamethasone promotes the reaction Tretinoin results in increased expression of and results in increased activity of SLC5A5 protein		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation10	Dexamethasone promotes the reaction Tretinoin results in increased expression of SLC5A5 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation11	ESR1 protein promotes the reaction Tretinoin results in increased expression of SLC5A5 protein		[50]
Regulation Mechanism			Transcription Factor Info
DT Modulation12	Hydrocortisone promotes the reaction Tretinoin affects the localization of SLC5A5 protein		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation13	Hydrocortisone promotes the reaction Tretinoin results in increased expression of SLC5A5 protein		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation14	Tretinoin affects the localization of SLC5A5 protein		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation15	Tretinoin inhibits the reaction TSHB protein results in increased expression of SLC5A5 protein		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation16	Tretinoin results in increased expression of and results in increased activity of SLC5A5 protein		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation17	Tretinoin results in increased expression of SLC5A5 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation18	Tretinoin results in increased expression of SLC5A5 protein		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation19	Troglitazone co-treated with Tretinoin results in increased expression of SLC5A5 mRNA		[3]
Regulation Mechanism			Transcription Factor Info
DT Modulation20	Wortmannin inhibits the reaction Carbamazepine promotes the reaction Tretinoin results in increased expression of SLC5A5 protein		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	BRAF protein mutant form affects the reaction Vorinostat affects the reaction TSHB protein co-treated with Vemurafenib affects the expression of SLC5A5 mRNA		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	TSHB protein promotes the reaction Vemurafenib co-treated with Vorinostat results in increased expression of SLC5A5 protein		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Vemurafenib co-treated with Vorinostat results in increased expression of SLC5A5 protein		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Vorinostat affects the reaction BRAF protein mutant form affects the susceptibility to Vemurafenib affects the reaction TSHB protein affects the expression of SLC5A5 mRNA		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Vorinostat affects the reaction BRAF protein mutant form affects the susceptibility to Vemurafenib which affects the expression of SLC5A5 mRNA		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Vorinostat affects the reaction TSHB protein co-treated with Vemurafenib affects the expression of SLC5A5 mRNA		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Dibutyl Phthalate inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Colforsin inhibits the reaction Tretinoin co-treated with Hydrocortisone results in increased activity of SLC5A5 protein		[19]
Regulation Mechanism			Transcription Factor Info
1-Methyl-3-isobutylxanthine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1-Methyl-3-isobutylxanthine promotes the reaction Tretinoin co-treated with Hydrocortisone affects the localization of SLC5A5 protein		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	1-Methyl-3-isobutylxanthine promotes the reaction Tretinoin co-treated with Hydrocortisone results in increased expression of SLC5A5 protein		[19]
Regulation Mechanism			Transcription Factor Info
2,2',4,4'-tetrabromodiphenyl ether	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
2,3',4,4',5-pentachlorobiphenyl	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2,3',4,4',5-pentachlorobiphenyl results in decreased expression of SLC5A5 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	2,3',4,4',5-pentachlorobiphenyl results in decreased expression of SLC5A5 protein		[21]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction 2,3',4,4',5-pentachlorobiphenyl results in decreased expression of SLC5A5 protein		[21]
Regulation Mechanism			Transcription Factor Info
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction 2,3',4,4',5-pentachlorobiphenyl results in decreased expression of SLC5A5 protein		[21]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction Carbamazepine promotes the reaction Tretinoin results in increased expression of SLC5A5 protein		[22]
Regulation Mechanism			Transcription Factor Info
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid promotes the reaction SLC5A5 protein results in increased uptake of Sodium Iodide		[23]
Regulation Mechanism			Transcription Factor Info
5-nitro-2-(3-phenylpropylamino)benzoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SLC5A5 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	abrine results in increased expression of SLC5A5 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
Adenosine Triphosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Adenosine Triphosphate inhibits the reaction TSHB protein results in increased expression of SLC5A5 protein		[19]
Regulation Mechanism			Transcription Factor Info
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC5A5 promoter		[27]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in decreased methylation of SLC5A5 exon		[27]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Benzo(a)pyrene results in increased methylation of SLC5A5 3' UTR		[27]
Regulation Mechanism			Transcription Factor Info
butylbenzyl phthalate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	butylbenzyl phthalate results in increased expression of SLC5A5 mRNA		[12]
Regulation Mechanism			Transcription Factor Info
captax	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	captax inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
Carbamazepine	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction Carbamazepine promotes the reaction Tretinoin results in increased expression of SLC5A5 protein		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Carbamazepine promotes the reaction Tretinoin results in increased expression of SLC5A5 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Carbamazepine promotes the reaction Tretinoin results in increased expression of SLC5A5 protein		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Wortmannin inhibits the reaction Carbamazepine promotes the reaction Tretinoin results in increased expression of SLC5A5 protein		[22]
Regulation Mechanism			Transcription Factor Info
cypermethrin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cypermethrin inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
decamethrin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	decamethrin inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
Dexamethasone	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dexamethasone co-treated with Tretinoin results in increased expression of SLC5A5 mRNA		[3]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Dexamethasone promotes the reaction SLC5A5 protein results in increased uptake of Iodides		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Dexamethasone promotes the reaction Tretinoin results in increased expression of and results in increased activity of SLC5A5 protein		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Dexamethasone promotes the reaction Tretinoin results in increased expression of SLC5A5 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
diisodecyl phthalate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	diisodecyl phthalate results in increased expression of SLC5A5 mRNA		[12]
Regulation Mechanism			Transcription Factor Info
di-n-butylphosphoric acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	di-n-butylphosphoric acid affects the expression of SLC5A5 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
di-n-octyl phthalate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	di-n-octyl phthalate results in increased expression of SLC5A5 mRNA		[12]
Regulation Mechanism			Transcription Factor Info
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC5A5 protein promotes the reaction Doxorubicin results in increased uptake of Sodium Pertechnetate Tc 99m		[31]
Regulation Mechanism			Transcription Factor Info
dysidenin	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dysidenin inhibits the reaction SLC5A5 protein results in increased uptake of perrhenate analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	dysidenin inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	dysidenin inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m		[32]
Regulation Mechanism			Transcription Factor Info
efavirenz	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	efavirenz co-treated with TSHB protein results in increased expression of SLC5A5 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	efavirenz co-treated with TSHB protein results in increased expression of SLC5A5 protein		[33]
Regulation Mechanism			Transcription Factor Info
ethyl-p-hydroxybenzoate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ethyl-p-hydroxybenzoate results in decreased expression of SLC5A5 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
etoxazole	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	etoxazole inhibits the reaction SLC5A5 protein results in increased uptake of Iodides		[35]
Regulation Mechanism			Transcription Factor Info
Hydrocortisone	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1-Methyl-3-isobutylxanthine promotes the reaction Tretinoin co-treated with Hydrocortisone affects the localization of SLC5A5 protein		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	1-Methyl-3-isobutylxanthine promotes the reaction Tretinoin co-treated with Hydrocortisone results in increased expression of SLC5A5 protein		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Colforsin inhibits the reaction Tretinoin co-treated with Hydrocortisone results in increased activity of SLC5A5 protein		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Hydrocortisone promotes the reaction Tretinoin affects the localization of SLC5A5 protein		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Hydrocortisone promotes the reaction Tretinoin results in increased expression of SLC5A5 protein		[19]
Regulation Mechanism			Transcription Factor Info
Indomethacin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Indomethacin inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
Iodides	11 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dexamethasone promotes the reaction SLC5A5 protein results in increased uptake of Iodides		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	etoxazole inhibits the reaction SLC5A5 protein results in increased uptake of Iodides		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	mepanipyrim inhibits the reaction SLC5A5 protein results in increased uptake of Iodides		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	methoxyfenozide inhibits the reaction SLC5A5 protein results in increased uptake of Iodides		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Niclosamide inhibits the reaction SLC5A5 protein results in increased uptake of Iodides		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	oxyfluorofen inhibits the reaction SLC5A5 protein results in increased uptake of Iodides		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Iodides		[36]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	potassium perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Iodides		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	SLC5A5 protein results in increased uptake of Iodides		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation10	thiocyanate inhibits the reaction SLC5A5 protein results in increased uptake of Iodides		[36]
Regulation Mechanism			Transcription Factor Info
DT Modulation11	triclocarban inhibits the reaction SLC5A5 protein results in increased uptake of Iodides		[35]
Regulation Mechanism			Transcription Factor Info
Iodine	16 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Butyrates co-treated with Decitabine results in increased expression of SLC5A5 mRNA which results in increased uptake of Iodine		[4]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	captax inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	cypermethrin inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	decamethrin inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	Dibutyl Phthalate inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	Indomethacin inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	mancozeb inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation10	polymarcine inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation11	potassium perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation12	SLC5A5 protein affects the transport of Iodine		[37]
Regulation Mechanism			Transcription Factor Info
DT Modulation13	SLC5A5 protein results in increased uptake of Iodine		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation14	sodium perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation15	sodium thiocyanate inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation16	triclocarban inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
licochalcone B	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	licochalcone B results in increased expression of SLC5A5 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
mancozeb	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	mancozeb inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
mepanipyrim	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	mepanipyrim inhibits the reaction SLC5A5 protein results in increased uptake of Iodides		[35]
Regulation Mechanism			Transcription Factor Info
methoxyfenozide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methoxyfenozide inhibits the reaction SLC5A5 protein results in increased uptake of Iodides		[35]
Regulation Mechanism			Transcription Factor Info
mibolerone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	mibolerone promotes the reaction SLC5A5 protein results in increased uptake of Sodium Iodide		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	perchlorate inhibits the reaction mibolerone promotes the reaction SLC5A5 protein results in increased uptake of Sodium Iodide		[40]
Regulation Mechanism			Transcription Factor Info
mono-(2-ethylhexyl)phthalate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	mono-(2-ethylhexyl)phthalate results in decreased expression of SLC5A5 protein		[41]
Regulation Mechanism			Transcription Factor Info
Nevirapine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nevirapine co-treated with TSHB protein results in increased expression of SLC5A5 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Nevirapine co-treated with TSHB protein results in increased expression of SLC5A5 protein		[33]
Regulation Mechanism			Transcription Factor Info
Niclosamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Niclosamide inhibits the reaction SLC5A5 protein results in increased uptake of Iodides		[35]
Regulation Mechanism			Transcription Factor Info
Ouabain	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ouabain inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide		[23]
Regulation Mechanism			Transcription Factor Info
oxyfluorofen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	oxyfluorofen inhibits the reaction SLC5A5 protein results in increased uptake of Iodides		[35]
Regulation Mechanism			Transcription Factor Info
Palmitic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Palmitic Acid results in decreased expression of SLC5A5 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
perchlorate	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perchlorate inhibits the reaction mibolerone promotes the reaction SLC5A5 protein results in increased uptake of Sodium Iodide		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	perchlorate inhibits the reaction SLC5A5 protein results in increased abundance of Sodium Iodide		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Iodides		[36]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide		[44]
Regulation Mechanism			Transcription Factor Info
perrhenate	10 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dysidenin inhibits the reaction SLC5A5 protein results in increased uptake of perrhenate analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	perrhenate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	perrhenate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	SLC5A5 protein results in increased uptake of perrhenate		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	SLC5A5 protein results in increased uptake of perrhenate analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	sodium bromide inhibits the reaction SLC5A5 protein results in increased uptake of perrhenate analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	sodium chlorate inhibits the reaction SLC5A5 protein results in increased uptake of perrhenate analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	Sodium Iodide inhibits the reaction SLC5A5 protein results in increased uptake of perrhenate analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	sodium perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of perrhenate analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation10	sodium thiocyanate inhibits the reaction SLC5A5 protein results in increased uptake of perrhenate analog		[32]
Regulation Mechanism			Transcription Factor Info
potassium perchlorate	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	potassium perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Iodides		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	potassium perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	potassium perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide		[45]
Regulation Mechanism			Transcription Factor Info
sodium bromide	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium bromide inhibits the reaction SLC5A5 protein results in increased uptake of perrhenate analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium bromide inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium bromide inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m		[32]
Regulation Mechanism			Transcription Factor Info
sodium chlorate	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium chlorate inhibits the reaction SLC5A5 protein results in increased uptake of perrhenate analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium chlorate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium chlorate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m		[32]
Regulation Mechanism			Transcription Factor Info
Sodium Iodide	19 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid promotes the reaction SLC5A5 protein results in increased uptake of Sodium Iodide		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	dysidenin inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	mibolerone promotes the reaction SLC5A5 protein results in increased uptake of Sodium Iodide		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Ouabain inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	perchlorate inhibits the reaction mibolerone promotes the reaction SLC5A5 protein results in increased uptake of Sodium Iodide		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	perchlorate inhibits the reaction SLC5A5 protein results in increased abundance of Sodium Iodide		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide		[44]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	perrhenate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	potassium perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation10	SLC5A5 protein results in decreased export of Sodium Iodide		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation11	SLC5A5 protein results in increased abundance of Sodium Iodide		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation12	SLC5A5 protein results in increased uptake of Sodium Iodide		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation13	sodium bromide inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation14	sodium chlorate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation15	Sodium Iodide inhibits the reaction SLC5A5 protein results in increased uptake of perrhenate analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation16	Sodium Iodide inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation17	sodium perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide		[46]
Regulation Mechanism			Transcription Factor Info
DT Modulation18	sodium perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation19	sodium thiocyanate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide analog		[32]
Regulation Mechanism			Transcription Factor Info
sodium perchlorate	6 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of perrhenate analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide		[46]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	sodium perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	sodium perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	sodium perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Technetium		[47]
Regulation Mechanism			Transcription Factor Info
Sodium Pertechnetate Tc 99m	9 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dysidenin inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	perrhenate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	SLC5A5 protein promotes the reaction Doxorubicin results in increased uptake of Sodium Pertechnetate Tc 99m		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	sodium bromide inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	sodium chlorate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	Sodium Iodide inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	sodium perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	sodium thiocyanate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m		[32]
Regulation Mechanism			Transcription Factor Info
sodium thiocyanate	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium thiocyanate inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium thiocyanate inhibits the reaction SLC5A5 protein results in increased uptake of perrhenate analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium thiocyanate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Iodide analog		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	sodium thiocyanate inhibits the reaction SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m		[32]
Regulation Mechanism			Transcription Factor Info
tazarotene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tazarotene results in increased expression of SLC5A5 mRNA		[3]
Regulation Mechanism			Transcription Factor Info
Technetium	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC5A5 protein results in increased uptake of Technetium		[47]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium perchlorate inhibits the reaction SLC5A5 protein results in increased uptake of Technetium		[47]
Regulation Mechanism			Transcription Factor Info
thiocyanate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC5A5 protein affects the transport of thiocyanate		[48]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	thiocyanate inhibits the reaction SLC5A5 protein results in increased uptake of Iodides		[36]
Regulation Mechanism			Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiram results in increased expression of SLC5A5 mRNA		[49]
Regulation Mechanism			Transcription Factor Info
trichostatin A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	trichostatin A results in increased expression of SLC5A5 mRNA		[3]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	trichostatin A results in increased expression of SLC5A5 protein		[3]
Regulation Mechanism			Transcription Factor Info
triclocarban	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	triclocarban inhibits the reaction SLC5A5 protein results in increased uptake of Iodides		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	triclocarban inhibits the reaction SLC5A5 protein results in increased uptake of Iodine		[20]
Regulation Mechanism			Transcription Factor Info
Vemurafenib	9 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	BRAF protein mutant form affects the reaction TSHB protein co-treated with Vemurafenib affects the expression of SLC5A5 mRNA		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	BRAF protein mutant form affects the reaction Vorinostat affects the reaction TSHB protein co-treated with Vemurafenib affects the expression of SLC5A5 mRNA		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	BRAF protein mutant form affects the susceptibility to Vemurafenib which affects the expression of SLC5A5 mRNA		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	TSHB protein co-treated with Vemurafenib affects the expression of SLC5A5 mRNA		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	TSHB protein promotes the reaction Vemurafenib co-treated with Vorinostat results in increased expression of SLC5A5 protein		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Vemurafenib co-treated with Vorinostat results in increased expression of SLC5A5 protein		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	Vorinostat affects the reaction BRAF protein mutant form affects the susceptibility to Vemurafenib affects the reaction TSHB protein affects the expression of SLC5A5 mRNA		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	Vorinostat affects the reaction BRAF protein mutant form affects the susceptibility to Vemurafenib which affects the expression of SLC5A5 mRNA		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	Vorinostat affects the reaction TSHB protein co-treated with Vemurafenib affects the expression of SLC5A5 mRNA		[9]
Regulation Mechanism			Transcription Factor Info
Wortmannin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Wortmannin inhibits the reaction Carbamazepine promotes the reaction Tretinoin results in increased expression of SLC5A5 protein		[22]
Regulation Mechanism			Transcription Factor Info
Mycotoxins
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 results in decreased methylation of SLC5A5 intron		[26]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Troglitazone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Troglitazone increases the expression of SLC5A5		[2]
Regulation Mechanism	via enhancement of Peroxisome proliferator-activated receptor gamma (PPARG)		Transcription Factor Info
Cell System	Human thyroid gland follicular carcinoma cells (FTC-133)
Alitretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Alitretinoin increases the expression of SLC5A5		[3]
Azacitidine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Azacitidine increases the expression of SLC5A5		[3]
Tazarotene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tazarotene increases the expression of SLC5A5		[3]
Valproic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of SLC5A5		[3]
Decitabine	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Decitabine increases the expression of SLC5A5		[4]
Amiodarone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Amiodarone inhibits the expression of SLC5A5		[5]
Theophylline	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Theophylline increases the expression of SLC5A5		[6]
Tretinoin	21 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of SLC5A5		[7]
Methimazole	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methimazole increases the expression of SLC5A5		[8]
Vorinostat	7 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vorinostat increases the expression of SLC5A5		[9]
Potassium perchlorate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Potassium perchlorate inhibits the activity of SLC5A5		[10]
Propylthiouracil	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Propylthiouracil induces the activity of SLC5A5		[11]
Drug in Phase 3 Trial
Resveratrol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Resveratrol increases the expression of SLC5A5		[18]
Drug in Phase 2 Trial
Colforsin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Colforsin increases the expression of SLC5A5		[3]
Genistein	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Genistein increases the expression of SLC5A5		[14]
Drug in Phase 1 Trial
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of SLC5A5		[3]
Butyrate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Butyrate increases the expression of SLC5A5		[4]
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Quercetin affects the expression of SLC5A5		[14]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 increases the expression of SLC5A5		[15]
Investigative Drug
Selumetinib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Selumetinib induces the activity of SLC5A5		[1]
Cell System	Thyroid cancer cell lines-NIS
Natural Product
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution affects the expression of SLC5A5		[17]
DT Modulation1	NOTCH1 mutant form inhibits the reaction Resveratrol results in increased expression of SLC5A5 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
Acute Toxic Substance
Cycloheximide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cycloheximide increases the expression of SLC5A5		[13]
Fungicide
Tebuconazole	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tebuconazole inhibits the expression of SLC5A5		[16]
tebuconazole	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tebuconazole results in decreased expression of SLC5A5 mRNA		[16]
Regulation Mechanism			Transcription Factor Info
Health and Environmental Toxicant
Butylbenzyl phthalate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Butylbenzyl phthalate increases the expression of SLC5A5		[12]
Dibutyl Phthalate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dibutyl Phthalate inhibits the expression of SLC5A5		[12]

References
1	Selumetinib Activity in Thyroid Cancer Cells: Modulation of Sodium Iodide Symporter and Associated miRNAs. Int J Mol Sci. 2018 Jul 17;19(7). pii: E2077.
2	Troglitazone, the peroxisome proliferator-activated receptor-gamma agonist, induces antiproliferation and redifferentiation in human thyroid cancer cell lines. Thyroid. 2005 Mar;15(3):222-31.
3	Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. Endocr Relat Cancer. 2006 Sep;13(3):797-826.
4	Increased iodine uptake in thyroid carcinoma after treatment with sodium butyrate and decitabine (5-Aza-dC). Otolaryngol Head Neck Surg. 2007 Nov;137(5):722-8.
5	Amiodarone reversibly decreases sodium-iodide symporter mRNA expression at therapeutic concentrations and induces antioxidant responses at supraphysiological concentrations in cultured human thyroid follicles. Thyroid. 2007 Dec;17(12):1189-200.
6	Effects of theophylline on radioiodide uptake in MCF-7 breast cancer and NIS gene-transduced SNU-C5 colon cancer cells. Cancer Biother Radiopharm. 2009 Apr;24(2):201-8.
7	Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9.
8	Thyroid organotypic rat and human cultures used to investigate drug effects on thyroid function, hormone synthesis and release pathways. Toxicol Appl Pharmacol. 2012 Apr 1;260(1):81-8.
9	Robust Thyroid Gene Expression and Radioiodine Uptake Induced by Simultaneous Suppression of BRAF V600E and Histone Deacetylase in Thyroid Cancer Cells. J Clin Endocrinol Metab. 2016 Mar;101(3):962-71.
10	Iodine Affects Differentiation and Migration Process in Trophoblastic Cells. Biol Trace Elem Res. 2016 Feb;169(2):180-8.
11	Propylthiouracil increases sodium/iodide symporter gene expression and iodide uptake in rat thyroid cells in the absence of TSH. Thyroid. 2012 Aug;22(8):844-52.
12	The promoter of the human sodium/iodide symporter responds to certain phthalate plasticisers. Mol Cell Endocrinol. 2005 Dec 1;244(1-2):75-8.
13	Protein synthesis inhibitors, in synergy with 5-azacytidine, restore sodium/iodide symporter gene expression in human thyroid adenoma cell line, KAK-1, suggesting trans-active transcriptional repressor. J Clin Endocrinol Metab. 2007 Mar;92(3):1080-7.
14	Antiproliferation and redifferentiation in thyroid cancer cell lines by polyphenol phytochemicals. J Korean Med Sci. 2011 Jul;26(7):893-9.
15	Inhibition of BRD4 suppresses tumor growth and enhances iodine uptake in thyroid cancer. Biochem Biophys Res Commun. 2016 Jan 15;469(3):679-85.
16	The azole fungicide tebuconazole affects human CYP1A1 and CYP1A2 expression by an aryl hydrocarbon receptor-dependent pathway. Food Chem Toxicol. 2019 Jan;123:481-491.
17	Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
18	Resveratrol induces differentiation markers expression in anaplastic thyroid carcinoma via activation of Notch1 signaling and suppresses cell growth. Mol Cancer Ther. 2013 Jul;12(7):1276-87.
19	Hydrocortisone and purinergic signaling stimulate sodium/iodide symporter (NIS)-mediated iodide transport in breast cancer cells. Mol Endocrinol. 2006;20(5):1121-37.
20	Development of a screening approach to detect thyroid disrupting chemicals that inhibit the human sodium iodide symporter (NIS). Toxicol In Vitro. 2017;40:66-78.
21	Molecular mechanisms of human thyrocyte dysfunction induced by low concentrations of polychlorinated biphenyl 118 through the Akt/FoxO3a/NIS pathway. J Appl Toxicol. 2015;35(9):992-8.
22	Stimulation of retinoic acid-induced functional sodium iodide symporter (NIS) expression and cytotoxicity of I by carbamazepine in breast cancer cells. Breast Cancer Res Treat. 2011;125(2):377-86.
23	Tumour-specific activation of the sodium/iodide symporter gene under control of the glucose transporter gene 1 promoter (GTI-1.3). Eur J Nucl Med Mol Imaging. 2003;30(5):748-56.
24	Early whole-genome transcriptional response induced by benzo[a]pyrene diol epoxide in a normal human cell line. Genomics. 2009;93(4):332-42.
25	Integration of transcriptomics, proteomics and metabolomics data to reveal the biological mechanisms of abrin injury in human lung epithelial cells. Toxicol Lett. 2019;312:1-10.
26	Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018;121:214-223.
27	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
28	Re-differentiation of thyroid carcinoma cell lines treated with 5-Aza-2'-deoxycytidine and retinoic acid. Mol Cell Endocrinol. 2009;307(1-2):142-8.
29	Dexamethasone stimulation of retinoic Acid-induced sodium iodide symporter expression and cytotoxicity of 131-I in breast cancer cells. J Clin Endocrinol Metab. 2006;91(1):69-78.
30	Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
31	Visualization of endogenous p53-mediated transcription in vivo using sodium iodide symporter. Clin Cancer Res. 2005;11(1):123-8.
32	Anion selectivity by the sodium iodide symporter. Endocrinology. 2003;144(1):247-52.
33	Reverse transcriptase inhibitors down-regulate cell proliferation in vitro and in vivo and restore thyrotropin signaling and iodine uptake in human thyroid anaplastic carcinoma. J Clin Endocrinol Metab. 2005;90(10):5663-71.
34	Risk assessment of parabens in a transcriptomics-based in vitro test. Chem Biol Interact. 2023;384:110699.
35	Evaluation of potential sodium-iodide symporter (NIS) inhibitors using a secondary Fischer rat thyroid follicular cell (FRTL-5) radioactive iodide uptake (RAIU) assay. Arch Toxicol. 2020;94(3):873-885.
36	The BeWo choriocarcinoma cell line as a model of iodide transport by placenta. Placenta. 2005;26(5):380-6.
37	Functional expression of sodium iodide symporter (NIS) in human breast cancer tissue. Breast Cancer Res Treat. 2003;77(2):157-65.
38	Enhanced expression of adenovirus-mediated sodium iodide symporter gene in MCF-7 breast cancer cells with retinoic acid treatment. J Nucl Med. 2007;48(3):398-404.
39	Integrated miRNA and mRNA omics reveal the anti-cancerous mechanism of Licochalcone B on Human Hepatoma Cell HepG2. Food Chem Toxicol. 2021;150:112096.
40	Probasin promoter (ARR(2)PB)-driven, prostate-specific expression of the human sodium iodide symporter (h-NIS) for targeted radioiodine therapy of prostate cancer. Cancer Res. 2003;63(22):7840-4.
41	Di(2-ethylhexyl) phthalate induced thyroid toxicity via endoplasmic reticulum stress: In vivo and in vitro study. Environ Toxicol. 2022;37(12):2924-2936.
42	Palmitic Acid Induced a Dedifferentiation Profile at the Transcriptome Level: A Collagen Synthesis but no Triglyceride Accumulation in Hepatocyte-Like Cells Derived From Human-Induced Pluripotent Stem Cells Cultivated Inside Organ on a Chip. J Appl Toxicol. 2025;45(3):460-471.
43	Establishment of a human hepatocellular carcinoma cell line highly expressing sodium iodide symporter for radionuclide gene therapy. J Nucl Med. 2004;45(9):1571-6.
44	Functional activity of human sodium/iodide symporter in tumor cell lines. Nuklearmedizin. 2003;42(1):15-8.
45	Dynamic iodide trapping by tumor cells expressing the thyroidal sodium iodide symporter. Biochem Biophys Res Commun. 2004;325(1):157-66.
46	The rat sodium iodide symporter gene permits more effective radioisotope concentration than the human sodium iodide symporter gene in human and rodent cancer cells. Cancer Gene Ther. 2003;10(1):14-22.
47	Imaging of human sodium-iodide symporter gene expression mediated by recombinant adenovirus in skeletal muscle of living rats. Eur J Nucl Med Mol Imaging. 2004;31(9):1304-11.
48	Transcellular thiocyanate transport by human airway epithelia. J Physiol. 2004;561(Pt 1):183-94.
49	High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ Health Perspect. 2024;132(4):47002.
50	Unliganded estrogen receptor-alpha activates transcription of the mammary gland Na+/I- symporter gene. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1487-96.

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