Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0425 Transporter Info
Gene Name SLC5A5
Transporter Name Sodium/iodide cotransporter
Gene ID
6528
UniProt ID
Q92911

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [1]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Blood; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

        CREM 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC5A5 gene in thyroid cancer condition [2]

TF Protein Name

 cAMP-responsive element modulator Transcription Factor Info

Affected Drug/Substrate

 Sodium iodide I 131

Studied Phenotype

 Thyroid cancer [ICD11: 2D10]

Tissue

 Thyroid gland

Related DT Changes

 Up regulating

Experimental Material

 Human thyroid gland papillary carcinoma cells (BHP2-7)

Detailed Description

 cAMP-responsive element modulator (CREM) has been reported to activate the transcription of SLC5A5 gene in thyroid cancer condition, which leads to an increased expression of the drug transporter Sodium/iodide cotransporter.

       Transcriptional Phenomenon2

 Repression of SLC5A5 gene in thyroid cancer condition [3]

TF Protein Name

 cAMP-responsive element modulator Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 cAMP-responsive element modulator (CREM) has been reported to repress the transcription of SLC5A5 gene in thyroid cancer condition, which leads to a decreased expression of the drug transporter Sodium/iodide cotransporter.

        JUND 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [4]

TF Protein Name

 Transcription factor JunD Transcription Factor Info

Tissue

 Colon; Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor JunD (JUND) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        ASCL2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [5]

TF Protein Name

 Achaete-scute homolog 2 Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Achaete-scute homolog 2 (ASCL2) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [6]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

        TFAP4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [1]

TF Protein Name

 Transcription factor AP-4 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-4 (TFAP4) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TFAP2C 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [6]

TF Protein Name

 Transcription factor AP-2 gamma Transcription Factor Info

Tissue

 Breast; Cervix; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        ESR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC5A5 gene in breast cancer condition [7]

TF Protein Name

 Estrogen receptor Transcription Factor Info

Studied Phenotype

 Breast cancer [ICD11: 2C60-2C6Z]

Tissue

 Breast

Related DT Changes

 Up regulating

Experimental Material

 Human breast adenocarcinoma cells (MDA-MB-231)

Detailed Description

 Estrogen receptor (ESR1) has been reported to activate the transcription of SLC5A5 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium/iodide cotransporter.

        NR3C1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC5A5 gene in ER(-) breast cancer condition [8]

TF Protein Name

 Glucocorticoid receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Glucocorticoid receptor (NR3C1) has been reported to activate the transcription of SLC5A5 gene in ER(-) breast cancer condition, which leads to an increased expression of the drug transporter Sodium/iodide cotransporter.

        PPARG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC5A5 gene in thyroid gland follicular carcinoma condition [9]

TF Protein Name

 Peroxisome proliferator-activated receptor gamma Transcription Factor Info

Studied Phenotype

 Thyroid gland follicular carcinoma [2D10.0]

Tissue

 Thyroid gland

Related DT Changes

 up regulating

Experimental Material

 Human thyroid gland follicular carcinoma cells (FTC-133)

Detailed Description

 Peroxisome proliferator-activated receptor gamma (PPARG), influenced by the exogenous troglitazone, has been reported to activate the transcription of SLC5A5 gene in thyroid gland follicular carcinoma condition , which leads to an increased expression of the drug transporter Sodium/iodide cotransporter.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 9 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [6]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [1]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Pancreatic ductal; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [5]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Pancreatic ductal; Stomach

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [5]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

        SP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [4]

TF Protein Name

 Transcription factor Sp1 Transcription Factor Info

Tissue

 Blood; Colon; Embryo; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor Sp1 (SP1) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

        YY1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [6]

TF Protein Name

 Transcriptional repressor protein YY1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Liver; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor protein YY1 (YY1) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

        ZBTB7A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [1]

TF Protein Name

 Zinc finger and BTB domain-containing protein 7A Transcription Factor Info

Tissue

 Bone marrow; Liver; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [4]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

        ZNF384 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [6]

TF Protein Name

 Zinc finger protein 384 Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 384 (ZNF384) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        HHEX 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC5A5 gene in breast cancer condition [10]

TF Protein Name

 Hematopoietically-expressed homeobox protein HHEX Transcription Factor Info

Studied Phenotype

 Breast cancer [ICD11: 2C60-2C6Z]

Tissue

 Breast

Related DT Changes

 Up regulating

Experimental Material

 human breast cancer cell isolates

Detailed Description

 Hematopoietically-expressed homeobox protein HHEX (HHEX) has been reported to activate the transcription of SLC5A5 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium/iodide cotransporter.

        PBX3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [4]

TF Protein Name

 Pre-B-cell leukemia transcription factor 3 Transcription Factor Info

Tissue

 Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

      Class3.2: Paired box factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        PAX5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [5]

TF Protein Name

 Paired box protein Pax-5 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Paired box protein Pax-5 (PAX5) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

        PAX8 

Click to Show/Hide to Show 3 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC5A5 gene in thyroid cancer condition

TF Protein Name

 Paired box protein Pax-8 Transcription Factor Info

Affected Drug/Substrate

 Radioiodine

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Paired box protein Pax-8 (PAX8) has been reported to activate the transcription of SLC5A5 gene in thyroid cancer condition, which leads to an increased expression of the drug transporter Sodium/iodide cotransporter.

       Transcriptional Phenomenon2

 Activation of SLC5A5 gene in cervical cancer condition [11]

TF Protein Name

 Paired box protein Pax-8 Transcription Factor Info

Studied Phenotype

 Cervical cancer [ICD11: 2C77]

Tissue

 Cervix

Related DT Changes

 Up regulating

Experimental Material

 Human human papillomavirus-related endocervical adenocarcinoma cells (HeLa)

Detailed Description

 Paired box protein Pax-8 (PAX8) has been reported to activate the transcription of SLC5A5 gene in cervical cancer condition, which leads to an increased expression of the drug transporter Sodium/iodide cotransporter.

       Transcriptional Phenomenon3

 Activation of SLC5A5 gene in health condition [12]

TF Protein Name

 Paired box protein Pax-8 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Thyroid gland

Related DT Changes

 Up regulating

Experimental Material

 Human thyroid gland follicular cells (Nthy-ori 3-1)

Detailed Description

 Paired box protein Pax-8 (PAX8) has been reported to activate the transcription of SLC5A5 gene in health condition, which leads to an increased expression of the drug transporter Sodium/iodide cotransporter.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC5A5 gene in embryonic stem cell condition [13]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of SLC5A5 gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter Sodium/iodide cotransporter.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        ELF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [4]

TF Protein Name

 ETS-related transcription factor Elf-1 Transcription Factor Info

Tissue

 Blood; Breast; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 ETS-related transcription factor Elf-1 (ELF1) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [5]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [6]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [1]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Bone marrow; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [6]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RELA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [1]

TF Protein Name

 Transcription factor p65 Transcription Factor Info

Tissue

 Blood; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor p65 (RELA) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

      Class6.2: STAT domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        STAT4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [5]

TF Protein Name

 Signal transducer and activator of transcription 4 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Signal transducer and activator of transcription 4 (STAT4) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

        STAT5B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A5 gene [4]

TF Protein Name

 Signal transducer and activator of transcription 5B Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Signal transducer and activator of transcription 5B (STAT5B) can directly bind to the SLC5A5 gene, which in turn affects the expression or function of the drug transporter Sodium/iodide cotransporter.

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TP53 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC5A5 gene in HFKS condition [14]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC5A5 gene in HFKS condition, which leads to an affected expression of the drug transporter Sodium/iodide cotransporter.

       Transcriptional Phenomenon2

 Binding to SLC5A5 gene in health condition [15]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC5A5 gene in health condition, which leads to an affected expression of the drug transporter Sodium/iodide cotransporter.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC5A5 gene in prostate cancer condition [16]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLC5A5 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Sodium/iodide cotransporter.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 Identification of cyclic adenosine 3',5'-monophosphate response element modulator as an activator of the human sodium/iodide symporter upstream enhancer. Endocrinology. 2008 May;149(5):2592-606.
3 Cyclic AMP-response element modulator inhibits the promoter activity of the sodium iodide symporter gene in thyroid cancer cells. Thyroid. 2012 May;22(5):487-93.
4 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
5 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
6 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-201. (ID:ENSG00000105641)
7 Unliganded estrogen receptor-alpha activates transcription of the mammary gland Na+/I- symporter gene. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1487-96.
8 Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer. Cancer Res. 2011;71(20):6360-70.
9 Troglitazone, the peroxisome proliferator-activated receptor-gamma agonist, induces antiproliferation and redifferentiation in human thyroid cancer cell lines. Thyroid. 2005 Mar;15(3):222-31.
10 HEX expression and localization in normal mammary gland and breast carcinoma. BMC Cancer. 2006 Jul 19;6:192.
11 Transcriptional regulation of human sodium/iodide symporter gene: a role for redox factor-1. Endocrinology. 2004 Mar;145(3):1290-3.
12 PAX8PPARgamma stimulates cell viability and modulates expression of thyroid-specific genes in a human thyroid cell line. Thyroid. 2007 Jun;17(6):497-509.
13 An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
14 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
15 Distinct p53 genomic binding patterns in normal and cancer-derived human cells. Cell Cycle. 2011;10(24):4237-49.
16 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.

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