Drug Transporter (DT) Information

General Information of DT
DT ID DTD0159
Gene Name SLC23A2
Protein Name Sodium-dependent vitamin C transporter 2
Gene ID
9962
UniProt ID
Q9UGH3
TCDB ID
2.A.40.6.2
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms KIAA0238; NBTL1; Na(+)/L-ascorbic acid transporter 2; Nucleobase transporter-like 1 protein; SLC23A2; SVCT2; Solute carrier family 23 member 2; YSPL2; Yolk sac permease-like molecule 2; hSVCT2
DT Family Nucleobase/Ascorbate Transporter (NAT) Or Nucleobase:Cation Symporter-2 (NCS2) Family ;
Tissue Specificity Ubiquitous.
Function This sodium/ascorbate cotransporter mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
Endogenous Substrate(s) Ca2+; Mg2+; Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium-dependent vitamin C transporter 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium-dependent vitamin C transporter 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium-dependent vitamin C transporter 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Sodium-dependent vitamin C transporter 2
Microbiota Influence (MBI)

(β) Post-translational Modification of Sodium-dependent vitamin C transporter 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium-dependent vitamin C transporter 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium-dependent vitamin C transporter 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium-dependent vitamin C transporter 2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium-dependent vitamin C transporter 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium-dependent vitamin C transporter 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Vitamin C
 Approved Drug Info Vitamin C deficiency 5B56 [1]
References
1 Molecular characterization and transcriptional regulation of the sodium-dependent vitamin C transporter genes (slc23a1 and slc23a2) in a teleost fish, the Senegalese sole (Solea senegalensis). Comp Biochem Physiol B Biochem Mol Biol. 2012 Mar;161(3):208-18.

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