Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0159 Transporter Info
Gene Name	SLC23A2
Transporter Name	Sodium-dependent vitamin C transporter 2
Gene ID	9962
UniProt ID	Q9UGH3

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Carbamazepine affects the expression of SLC23A2 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Valproic Acid affects the expression of SLC23A2 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Valproic Acid results in decreased methylation of SLC23A2 gene		[12]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC23A2 5' UTR		[33]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene affects the methylation of SLC23A2 intron		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Benzo(a)pyrene results in decreased methylation of SLC23A2 promoter		[33]
Regulation Mechanism			Transcription Factor Info
1-Methyl-3-isobutylxanthine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in increased expression of SLC23A2 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC23A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
6-deoxy-6-bromoascorbic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC23A2 protein affects the transport of 6-deoxy-6-bromoascorbic acid		[25]
Regulation Mechanism			Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLC23A2 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
Ascorbic Acid	8 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ascorbic Acid inhibits the reaction nickel sulfate results in decreased expression of SLC23A2 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Diclofenac inhibits the reaction SLC23A2 protein results in increased uptake of Ascorbic Acid		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Estradiol inhibits the reaction SLC23A2 protein results in increased uptake of Ascorbic Acid		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Genistein inhibits the reaction SLC23A2 protein results in increased uptake of Ascorbic Acid		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Hydrocortisone inhibits the reaction SLC23A2 protein results in increased uptake of Ascorbic Acid		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Indomethacin inhibits the reaction SLC23A2 protein results in increased uptake of Ascorbic Acid		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	Progesterone inhibits the reaction SLC23A2 protein results in increased uptake of Ascorbic Acid		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	Quercetin inhibits the reaction SLC23A2 protein results in increased uptake of Ascorbic Acid		[32]
Regulation Mechanism			Transcription Factor Info
bisphenol A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A affects the expression of SLC23A2 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bisphenol A results in decreased expression of SLC23A2 protein		[22]
Regulation Mechanism			Transcription Factor Info
bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in increased expression of SLC23A2 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	butyraldehyde results in decreased expression of SLC23A2 mRNA		[17]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in decreased expression of SLC23A2 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC23A2 gene		[38]
Regulation Mechanism			Transcription Factor Info
Cisplatin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cisplatin co-treated with jinfukang results in increased expression of SLC23A2 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in decreased expression of SLC23A2 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
Dexamethasone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in increased expression of SLC23A2 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
Diclofenac	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diclofenac inhibits the reaction SLC23A2 protein results in increased uptake of Ascorbic Acid		[32]
Regulation Mechanism			Transcription Factor Info
dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dicrotophos results in increased expression of SLC23A2 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC23A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the reaction SLC23A2 protein results in increased uptake of Ascorbic Acid		[32]
Regulation Mechanism			Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	FR900359 results in increased phosphorylation of SLC23A2 protein		[41]
Regulation Mechanism			Transcription Factor Info
Genistein	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Genistein inhibits the reaction SLC23A2 protein results in increased uptake of Ascorbic Acid		[32]
Regulation Mechanism			Transcription Factor Info
Hydrocortisone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Hydrocortisone inhibits the reaction SLC23A2 protein results in increased uptake of Ascorbic Acid		[32]
Regulation Mechanism			Transcription Factor Info
Indomethacin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Indomethacin inhibits the reaction SLC23A2 protein results in increased uptake of Ascorbic Acid		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in increased expression of SLC23A2 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
Manganese	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC23A2 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC23A2 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
nickel sulfate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ascorbic Acid inhibits the reaction nickel sulfate results in decreased expression of SLC23A2 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	nickel sulfate results in decreased expression of SLC23A2 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
Palmitic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Palmitic Acid results in increased phosphorylation of SLC23A2 protein		[42]
Regulation Mechanism			Transcription Factor Info
PCI 5002	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	PCI 5002 co-treated with Zinc results in increased expression of SLC23A2 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
Progesterone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Progesterone inhibits the reaction SLC23A2 protein results in increased uptake of Ascorbic Acid		[32]
Regulation Mechanism			Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in decreased expression of SLC23A2 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLC23A2 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC23A2 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
Sodium Dodecyl Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium Dodecyl Sulfate results in increased expression of SLC23A2 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
Tetrachlorodibenzodioxin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin results in decreased expression of SLC23A2 mRNA		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Tetrachlorodibenzodioxin results in increased expression of SLC23A2 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiram results in decreased expression of SLC23A2 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
trichostatin A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC23A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	trichostatin A results in increased expression of SLC23A2 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
Zinc	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	PCI 5002 co-treated with Zinc results in increased expression of SLC23A2 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
Mycotoxins
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 results in increased methylation of SLC23A2 intron		[28]
Regulation Mechanism			Transcription Factor Info
aflatoxin B2	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aflatoxin B2 results in increased methylation of SLC23A2 intron		[28]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Carbamazepine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Carbamazepine increases the expression of SLC23A2		[1]
Ursodeoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ursodeoxycholic Acid increases the expression of SLC23A2		[2]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid increases the expression of SLC23A2		[3]
Acetaminophen	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC23A2		[4]
DT Modulation2	Acetaminophen results in increased expression of SLC23A2 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zidovudine increases the expression of SLC23A2		[5]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine increases the expression of SLC23A2		[6]
Rifampin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Rifampin increases the expression of SLC23A2		[7]
Leflunomide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Leflunomide increases the expression of SLC23A2		[8]
Dronabinol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dronabinol increases the expression of SLC23A2		[9]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the expression of SLC23A2		[10]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sunitinib increases the expression of SLC23A2		[11]
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of SLC23A2		[12]
Chenodeoxycholic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Chenodeoxycholic acid activates the activity of SLC23A2		[2], [13]
Vitamin C	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vitamin C modulates the activity of SLC23A2		[14]
Drug in Phase 2 Trial
Taurocholic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Taurocholic Acid increases the expression of SLC23A2		[2]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A inhibits the expression of SLC23A2		[22]
Drug in Phase 1 Trial
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of SLC23A2		[18]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 increases the expression of SLC23A2		[16]
Natural Product
Bilirubin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bilirubin increases the expression of SLC23A2		[2]
Caffeine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Caffeine results in increased phosphorylation of SLC23A2 protein		[36]
Regulation Mechanism			Transcription Factor Info
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the reaction SLC23A2 protein results in increased uptake of Ascorbic Acid		[32]
Regulation Mechanism			Transcription Factor Info
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin inhibits the expression of SLC23A2		[19]
Carcinogen
Benzo(a)pyrene	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene increases the expression of SLC23A2		[15]
Arsenic	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic affects the methylation of SLC23A2 gene		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC23A2 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
Pesticide/Insecticide
Dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dicrotophos increases the expression of SLC23A2		[20]
Health and Environmental Toxicant
Butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Butyraldehyde inhibits the expression of SLC23A2		[17]
Lead	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Lead affects the expression of SLC23A2		[21]

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Detail Information of Exogenous Modulation

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