Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0159 Transporter Info
Gene Name SLC23A2
Transporter Name Sodium-dependent vitamin C transporter 2
Gene ID
9962
UniProt ID
Q9UGH3

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        CEBPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein alpha Transcription Factor Info

Tissue

 Blood; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [2]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Bone

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [3]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Blood; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

        JUN 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC23A2 gene in K562 cells [4]

TF Protein Name

 Transcription factor Jun Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor Jun (JUN) has been reported to bind to the transcription of SLC23A2 gene in K562 cells, which leads to an affected expression of the drug transporter Sodium-dependent vitamin C transporter 2.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 8 TF(s) Regulating This DT

        ASCL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [5]

TF Protein Name

 Achaete-scute homolog 1 Transcription Factor Info

Tissue

 Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Achaete-scute homolog 1 (ASCL1) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

        MITF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC23A2 gene in melanoma condition [6]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC23A2 gene in melanoma condition, which leads to an increased expression of the drug transporter Sodium-dependent vitamin C transporter 2.

        MYC 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC23A2 gene in embryonic stem cells condition [7]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of SLC23A2 gene in embryonic stem cells condition, which leads to an affected expression of the drug transporter Sodium-dependent vitamin C transporter 2.

        MYOD1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [5]

TF Protein Name

 Myoblast determination protein 1 Transcription Factor Info

Tissue

 Myotube

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myoblast determination protein 1 (MYOD1) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

        TCF12 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [3]

TF Protein Name

 Transcription factor 12 Transcription Factor Info

Tissue

 Blood; Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor 12 (TCF12) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [5]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

        USF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [1]

TF Protein Name

 Upstream stimulatory factor 1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Colon; Embryo; Liver; Lung; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Upstream stimulatory factor 1 (USF1) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

        USF2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [2]

TF Protein Name

 Upstream stimulatory factor 2 Transcription Factor Info

Tissue

 Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Upstream stimulatory factor 2 (USF2) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TFAP2C 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [3]

TF Protein Name

 Transcription factor AP-2 gamma Transcription Factor Info

Tissue

 Breast; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC23A2 gene in prostate cancer condition [8]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC23A2 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium-dependent vitamin C transporter 2.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC23A2 gene in health condition [9]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC23A2 gene in health condition, which leads to an affected expression of the drug transporter Sodium-dependent vitamin C transporter 2.

        HNF4G 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [2]

TF Protein Name

 Hepatocyte nuclear factor 4-gamma Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 4-gamma (HNF4G) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

        NR2F2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [5]

TF Protein Name

 COUP transcription factor 2 Transcription Factor Info

Tissue

 Breast; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 COUP transcription factor 2 (NR2F2) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [5]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Erythroid transcription factor (GATA1) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC23A2 gene in gastric cancer condition [10]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Krueppel-like factor 5 (KLF5) has been reported to activate the transcription of SLC23A2 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Sodium-dependent vitamin C transporter 2.

        KLF9 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [3]

TF Protein Name

 Krueppel-like factor 9 Transcription Factor Info

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 9 (KLF9) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

        SP1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC23A2 gene in brain neuroblastoma condition [11]

TF Protein Name

 Transcription factor Sp1 Transcription Factor Info

Affected Drug/Substrate

 Ascorbic acid

Studied Phenotype

 Brain neuroblastoma [ICD11: 2A00.11]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6 mice

Detailed Description

 Transcription factor Sp1 (SP1) has been reported to activate the transcription of SLC23A2 gene in brain neuroblastoma condition, which leads to an increased expression of the drug transporter Sodium-dependent vitamin C transporter 2.

       Transcriptional Phenomenon2

 Activation of SLC23A2 gene in osteosarcoma condition [12]

TF Protein Name

 Transcriptional repressor protein YY1 /Transcription factor Sp1 Transcription Factor Info

Affected Drug/Substrate

 Ascorbic acid

Studied Phenotype

 Osteosarcoma [ICD11: 2B51]

Tissue

 Bone

Related DT Changes

 Up regulating

Experimental Material

 Human osteosarcoma cells (U2OS)

Detailed Description

 The transcriptional repressor protein YY1 (YY1) and the transcription factor Sp1 (SP1) have been reported to synergistically activate transcription of the SLC23A2 gene in osteosarcoma condition, which leads to an increased expression of the drug transporter sodium-dependent vitamin C transporter 2.

        SP3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC23A2 gene in osteosarcoma condition [12]

TF Protein Name

 Transcriptional repressor protein YY1 /Transcription factor Sp3 Transcription Factor Info

Affected Drug/Substrate

 Ascorbic acid

Studied Phenotype

 Osteosarcoma [ICD11: 2B51]

Tissue

 Bone

Related DT Changes

 Up regulating

Experimental Material

 Human osteosarcoma cells (U2OS)

Detailed Description

 The transcriptional repressor protein YY1 (YY1) and the Transcription factor Sp3 (SP3) have been reported to synergistically activate transcription of the SLC23A2 gene in osteosarcoma condition, which leads to an increased expression of the drug transporter sodium-dependent vitamin C transporter 2.

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC23A2 gene in podocyte condition [13]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of SLC23A2 gene in podocyte condition, which leads to an increased expression of the drug transporter Sodium-dependent vitamin C transporter 2.

        ZBTB7A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [1]

TF Protein Name

 Zinc finger and BTB domain-containing protein 7A Transcription Factor Info

Tissue

 Bone marrow; Liver; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        HNF1A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC23A2 gene in health condition [14]

TF Protein Name

 Hepatocyte nuclear factor 1-alpha Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Related DT Changes

 Up regulating

Detailed Description

 Hepatocyte nuclear factor 1-alpha (HNF1A), influenced by the generated by the gut microbiota and Gram negative bacteria, has been reported to activate the transcription of SLC23A2 gene in health condition, which leads to an increased expression of the drug transporter Sodium-dependent vitamin C transporter 2.

        HNF1B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC23A2 gene in renal cysts condition [15]

TF Protein Name

 Hepatocyte nuclear factor 1-beta Transcription Factor Info

Studied Phenotype

 Renal cysts [ICD11: GB80]

Tissue

 Kidney

Related DT Changes

 Down regulating

Experimental Material

 Zebrafish TgPT::EGFP)

Detailed Description

 Hepatocyte nuclear factor 1-beta (HNF1B) has been reported to repress the transcription of SLC23A2 gene in renal cysts condition, which leads to a decreased expression of the drug transporter Sodium-dependent vitamin C transporter 2.

        NANOG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC23A2 gene in HESC condition [16]

TF Protein Name

 Homeobox protein NANOG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein NANOG (NANOG) has been reported to activate the transcription of SLC23A2 gene in HESC condition, which leads to an increased expression of the drug transporter Sodium-dependent vitamin C transporter 2.

        PBX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC23A2 gene in ovarian cancer condition [17]

TF Protein Name

 Pre-B-cell leukemia transcription factor 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of SLC23A2 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Sodium-dependent vitamin C transporter 2.

        POU2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [2]

TF Protein Name

 POU domain, class 2, transcription factor 1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 POU domain, class 2, transcription factor 1 (POU2F1) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

        ZEB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [5]

TF Protein Name

 Zinc finger E-box-binding homeobox 1 Transcription Factor Info

Tissue

 Blood; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger E-box-binding homeobox 1 (ZEB1) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC23A2 gene in MCF7 cells [18]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLC23A2 gene in MCF7 cells, which leads to an affected expression of the drug transporter Sodium-dependent vitamin C transporter 2.

        E2F6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [1]

TF Protein Name

 Transcription factor E2F6 Transcription Factor Info

Tissue

 Bone marrow; Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F6 (E2F6) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [2]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Embryo; Liver; Pancreatic ductal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC23A2 gene [9]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLC23A2 gene in . condition, which leads to a affected expression of the drug transporter Sodium-dependent vitamin C transporter 2.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        FLI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC23A2 gene in megakaryocytes condition [19]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC23A2 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Sodium-dependent vitamin C transporter 2.

       Transcriptional Phenomenon2

 Direct binding to SLC23A2 gene [1]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

        MYB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [3]

TF Protein Name

 Transcriptional activator Myb Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional activator Myb (MYB) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC23A2 gene [3]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLC23A2 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent vitamin C transporter 2.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        NFKB1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC23A2 gene in enterotoxigenic Escherichia coli infection condition [20]

TF Protein Name

 Nuclear factor NF-kappa-B p105 subunit Transcription Factor Info

Affected Drug/Substrate

 Ascorbic acid

Studied Phenotype

 Enterotoxigenic Escherichia coli infection [ICD11: 1A03.1]

Tissue

 Jejunum

Related DT Changes

 Down regulating

Experimental Material

 BALB/c mice

Detailed Description

 Nuclear factor NF-kappa-B p105 subunit (NFKB1) has been reported to repress the transcription of SLC23A2 gene in enterotoxigenic Escherichia coli infection condition, which leads to a decreased expression of the drug transporter Sodium-dependent vitamin C transporter 2.

       Transcriptional Phenomenon2

 Repression of SLC23A2 gene in brain neuroblastoma condition [11]

TF Protein Name

 Nuclear factor NF-kappa-B p105 subunit Transcription Factor Info

Affected Drug/Substrate

 Ascorbic acid

Studied Phenotype

 Brain neuroblastoma [ICD11: 2A00.11]

Tissue

 Brain

Related DT Changes

 Down regulating

Experimental Material

 C57BL/6 mice

Detailed Description

 Nuclear factor NF-kappa-B p105 subunit (NFKB1) has been reported to repress the transcription of SLC23A2 gene in brain neuroblastoma condition, which leads to a decreased expression of the drug transporter Sodium-dependent vitamin C transporter 2.

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        TP53 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC23A2 gene in health condition [21]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Affected Drug/Substrate

 Ascorbic acid

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Embryo

Related DT Changes

 Down regulating

Experimental Material

 mouse embryo fibroblast cell isolates

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to repress the transcription of SLC23A2 gene in health condition, which leads to a decreased expression of the drug transporter Sodium-dependent vitamin C transporter 2.

        TP63 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC23A2 gene in epithelial to mesenchymal transition condition [22]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC23A2 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Sodium-dependent vitamin C transporter 2.

       Transcriptional Phenomenon2

 Binding to SLC23A2 gene in health condition [23]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC23A2 gene in health condition, which leads to an affected expression of the drug transporter Sodium-dependent vitamin C transporter 2.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC23A2 gene in hESCs [24]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC23A2 gene in human embryonic stem cells (hESCs), which leads to an increased expression of the drug transporter Sodium-dependent vitamin C transporter 2.
References
1 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
2 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
3 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-171. (ID:ENSG00000089057)
4 c-Jun binding site identification in K562 cells. J Genet Genomics. 2011;38(6):235-42.
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8 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
9 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
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11 Effect of Lipopolysaccharide and TNF alpha on Neuronal Ascorbic Acid Uptake. Mediators Inflamm. 2021 Jul 3;2021:4157132.
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13 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
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15 Transcriptional profiling of the zebrafish proximal tubule. Am J Physiol Renal Physiol. 2019 Aug 1;317(2):F478-F488.
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