Modelled DT Structure
Method: multi-sequence alignment based machine learning
Detail: Structure Info
Drug Transporter (DT) Information
| General Information of DT | |||||
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| DT ID | DTD0158 | ||||
| Gene Name | SLC23A1 | ||||
| Protein Name | Sodium-dependent vitamin C transporter 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
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| Synonyms | Na(+)/L-ascorbic acid transporter 1; SLC23A1; SVCT1; Solute carrier family 23 member 1; YSPL3; Yolk sac permease-like molecule 3; hSVCT1 | ||||
| DT Family | Nucleobase/Ascorbate Transporter (NAT) Or Nucleobase:Cation Symporter-2 (NCS2) Family ; | ||||
| Tissue Specificity | Highly expressed in adult small intestine,kidney, thymus, ovary, colon, prostate and liver, and in fetalkidney, liver and thymus. | ||||
| Function | This sodium/ascorbate cotransporter mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate. | ||||
| Endogenous Substrate(s) | Na+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Sodium-dependent vitamin C transporter 1 |
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(β) Cell Distribution Level of Sodium-dependent vitamin C transporter 1 |
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(γ) Organelle Distribution Level of Sodium-dependent vitamin C transporter 1 |
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Regulatory Variability Data of This DT |
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(α) Microbiota Influence of Sodium-dependent vitamin C transporter 1 |
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(β) Post-translational Modification of Sodium-dependent vitamin C transporter 1 |
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(γ) Transcriptional Regulation of Sodium-dependent vitamin C transporter 1 |
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(δ) Epigenetic Regulation of Sodium-dependent vitamin C transporter 1 |
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(ε) Exogenous Modulation of Sodium-dependent vitamin C transporter 1 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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(γ) Outward/inward-facing Conformation |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Sodium-dependent vitamin C transporter 1 |
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(β) Disease-specific Protein Abundances of Sodium-dependent vitamin C transporter 1 |
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(γ) Species- and Tissue-specific DT Abundances |
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| Molecular Transporting Profile of This DT | |||||
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Full List of Drug(s) Transported by This DT |
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Approved Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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Vitamin C
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Approved | Drug Info | Vitamin C deficiency | 5B56 | [1] |
| References | |||||
| 1 | A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature. 1999 May 6;399(6731):70-5. | ||||
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