Drug Transporter (DT) Information

General Information of DT
DT ID DTD0128
Gene Name SLC19A3
Protein Name Thiamine transporter 2
Gene ID
80704
UniProt ID
Q9BZV2
TCDB ID
2.A.48.1.4
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms BBGD; SLC19A3; Solute carrier family 19 member 3; THMD2; ThTr-2; ThTr2
DT Family Reduced Folate Carrier (RFC) Family ;
Tissue Specificity Widely expressed but most abundant inplacenta, kidney and liver.
Function This transporter mediates high affinity thiamine uptake, probably via a proton anti-port mechanism.
Disease(s) Vitamin B1 deficiency [ICD-11:5B5A]
Endogenous Substrate(s) Thiamine
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Thiamine transporter 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Thiamine transporter 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Thiamine transporter 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Thiamine transporter 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Thiamine transporter 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Thiamine transporter 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Thiamine transporter 2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

General Variability Data of This DT

(α) Genetic Polymorphisms of Thiamine transporter 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Thiamine transporter 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           2 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Metformin
 Approved Drug Info Type 2 diabetes 5A11 [1]
Vitamin B1
 Approved Drug Info Vitamin B1 deficiency 5B5A [2]

Drug-DT Affinity Assessed by Cell Line

 Approved Drug

 Click to Show/Hide the Full List of Drug:         12 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
Metformin Approved Drug Info Human embryonic kidney cells-hTHTR2 Km =1150 microM [1]
Metformin Approved Drug Info Human embryonic kidney cells-hTHTR2 Km =1150 microM [1]
Metformin Approved Drug Info Human embryonic kidney cells-hTHTR2 Km =1150 microM [1]
Metformin Approved Drug Info Human embryonic kidney cells-hTHTR2 Km =1150 microM [1]
Metformin Approved Drug Info Human embryonic kidney cells-hTHTR2 Km =1150 microM [1]
Metformin Approved Drug Info Human embryonic kidney cells-hTHTR2 Km =1150 microM [1]
Metformin Approved Drug Info Human embryonic kidney cells-hTHTR2 Km =1150 microM [1]
Metformin Approved Drug Info Human embryonic kidney cells-hTHTR2 Km =1150 microM [1]
Metformin Approved Drug Info Human embryonic kidney cells-hTHTR2 Km =1150 microM [1]
Vitamin B1 Approved Drug Info Human embryonic kidney cells-hTHTR2 Km =3.16 microM [1]
Vitamin B1 Approved Drug Info Human embryonic kidney cells-hTHTR2 Km =3.16 microM [1]
Vitamin B1 Approved Drug Info Human embryonic kidney cells-hTHTR2 Km =3.16 microM [1]
References
1 Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). Mol Pharm. 2015 Dec 7;12(12):4301-10.
2 Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors. Mol Aspects Med. 2013 Apr-Jun;34(2-3):373-85.

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