Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0128 Transporter Info | |||||
| Gene Name | SLC19A3 | |||||
| Transporter Name | Thiamine transporter 2 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 8S4U | EM | 3.09 Å | Escherichia coli,Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 1-496 | Mutation | No | |||
| 8S5U | EM | 3.28 Å | Escherichia coli,Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 1-496 | Mutation | No | |||
| 8S5W | EM | 3.05 Å | Escherichia coli,Homo sapiens | [1] | ||
| Structure | ||||||
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| Corresponding chain | A | |||||
| Sequence Length | 535 | Mutation | No | |||
| 8S5Z | EM | 3 Å | Homo sapiens,Escherichia coli | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 535 | Mutation | No | |||
| 8S61 | EM | 3.53 Å | Escherichia coli,Homo sapiens | [1] | ||
| Structure | ||||||
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| Corresponding chain | A | |||||
| Sequence Length | 449 | Mutation | No | |||
| 8S62 | EM | 3.75 Å | Homo sapiens,Escherichia coli | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 535 | Mutation | No | |||
| 8XV2 | EM | 3.7 Å | Homo sapiens | [2] | ||
| Structure | ||||||
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| Corresponding chain | A | |||||
| Sequence Length | 11-496 | Mutation | No | |||
| 8XV5 | EM | 3.7 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 11-496 | Mutation | No | |||
| Modelled Structures of This DT | ||||||
| Click to Save PDB File in PDB Format | ||||||
| Detail Information of Modelled Structures | ||||||
| Method | multi-sequence alignment based machine learning | |||||
| AlphaFold Protein Structure Database | ||||||
| References | ||||||
| 1 | Structural basis of thiamine transport and drug recognition by SLC19A3. Nat Commun. 2024;15(1):8542. | |||||
| 2 | Substrate and drug recognition mechanisms of SLC19A3. Cell Res. 2024;34(6):458-461. | |||||
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