Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0128 Transporter Info
Gene Name SLC19A3
Transporter Name Thiamine transporter 2
Gene ID
80704
UniProt ID
Q9BZV2

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC19A3 gene in glioblastoma multiforme condition [1]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC19A3 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Thiamine transporter 2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC19A3 gene in prostate cancer condition [2]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC19A3 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Thiamine transporter 2.

        ESR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC19A3 gene [3]

TF Protein Name

 Estrogen receptor Transcription Factor Info

Tissue

 Bone; Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Estrogen receptor (ESR1) can directly bind to the SLC19A3 gene, which in turn affects the expression or function of the drug transporter Thiamine transporter 2.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC19A3 gene in health condition [4]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC19A3 gene in health condition, which leads to an affected expression of the drug transporter Thiamine transporter 2.

      Class2.3: C2H2 zinc finger factors

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        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC19A3 gene [5]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Pancreatic ductal; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC19A3 gene, which in turn affects the expression or function of the drug transporter Thiamine transporter 2.

        SP1 

Click to Show/Hide to Show 4 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC19A3 gene in colon cancer condition [6]

TF Protein Name

 Transcription factor Sp1 Transcription Factor Info

Affected Drug/Substrate

 Thiamin

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 Human colon adenocarcinoma cells (Caco-2)

Detailed Description

 Transcription factor Sp1 (SP1) has been reported to activate the transcription of SLC19A3 gene in colon cancer condition, which leads to an increased expression of the drug transporter Thiamine transporter 2.

       Transcriptional Phenomenon2

 Activation of SLC19A3 gene in thiamine-deficient condition

TF Protein Name

 Transcription factor Sp1 Transcription Factor Info

Affected Drug/Substrate

 Thiamine

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor Sp1 (SP1) has been reported to activate the transcription of SLC19A3 gene in thiamine-deficient condition, which leads to an increased expression of the drug transporter Thiamine transporter 2.

       Transcriptional Phenomenon3

 Activation of SLC19A3 gene in health condition [7]

TF Protein Name

 Transcription factor Sp1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor Sp1 (SP1) has been reported to activate the transcription of SLC19A3 gene in health condition, which leads to an increased expression of the drug transporter Thiamine transporter 2.

       Transcriptional Phenomenon4

 Activation of SLC19A3 gene in pancreatic acinar neoplasm condition [8]

TF Protein Name

 Transcription factor Sp1 Transcription Factor Info

Studied Phenotype

 Pancreatic acinar neoplasm [ICD11: 2E92.8]

Tissue

 Pancreas

Related DT Changes

 Up regulating

Experimental Material

 Mouse pancreatic acinar neoplasm cells (266-6)

Detailed Description

 Transcription factor Sp1 (SP1) has been reported to activate the transcription of SLC19A3 gene in pancreatic acinar neoplasm condition, which leads to an increased expression of the drug transporter Thiamine transporter 2.

        SP3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC19A3 gene in health condition [7]

TF Protein Name

 Transcription factor Sp3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor Sp3 (SP3) has been reported to activate the transcription of SLC19A3 gene in health condition, which leads to an increased expression of the drug transporter Thiamine transporter 2.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        NANOG 

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       Transcriptional Phenomenon1

 Activation of SLC19A3 gene in embryonic stem cells condition [9]

TF Protein Name

 Homeobox protein NANOG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein NANOG (NANOG) has been reported to activate the transcription of SLC19A3 gene in embryonic stem cells condition, which leads to an increased expression of the drug transporter Thiamine transporter 2.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC19A3 gene [5]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC19A3 gene, which in turn affects the expression or function of the drug transporter Thiamine transporter 2.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC19A3 gene [10]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC19A3 gene, which in turn affects the expression or function of the drug transporter Thiamine transporter 2.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

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        RBPJ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC19A3 gene in immortal lymphoblast cell lines (LCLs) condition [11]

TF Protein Name

 Recombining binding protein suppressor of hairless Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Recombining binding protein suppressor of hairless (RBPJ) has been reported to bind to the transcription of SLC19A3 gene in immortal lymphoblast cell lines (LCLs) condition, which leads to an affected expression of the drug transporter Thiamine transporter 2.

      Class6.7: Grainyhead domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GRHL2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC19A3 gene [12]

TF Protein Name

 Grainyhead-like protein 2 homolog Transcription Factor Info

Tissue

 Breast; Bronchus; Ovary

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC19A3 gene, which in turn affects the expression or function of the drug transporter Thiamine transporter 2.
References
1 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
2 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
3 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
4 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
5 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-274. (ID:ENSG00000135917)
6 Adaptive regulation of human intestinal thiamine uptake by extracellular substrate level: a role for THTR-2 transcriptional regulation. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15;305(8):G593-9.
7 Characterization of the 5'-regulatory region of the human thiamin transporter SLC19A3: in vitro and in vivo studies. Am J Physiol Gastrointest Liver Physiol. 2004;287(4):G822-9.
8 Mechanisms involved in the inhibitory effect of chronic alcohol exposure on pancreatic acinar thiamin uptake. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 1;306(7):G631-9.
9 Sall1 regulates embryonic stem cell differentiation in association with nanog. J Biol Chem. 2011;286(2):1037-45.
10 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
11 Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A. 2011;108(36):14902-7.
12 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.

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